MX2020005366A - Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson. - Google Patents

Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson.

Info

Publication number
MX2020005366A
MX2020005366A MX2020005366A MX2020005366A MX2020005366A MX 2020005366 A MX2020005366 A MX 2020005366A MX 2020005366 A MX2020005366 A MX 2020005366A MX 2020005366 A MX2020005366 A MX 2020005366A MX 2020005366 A MX2020005366 A MX 2020005366A
Authority
MX
Mexico
Prior art keywords
substituent
compounds
disease
treatment
parkinson
Prior art date
Application number
MX2020005366A
Other languages
English (en)
Inventor
Klaus Gjervig Jensen
Martin Juhl
Lisbet Kværnø
Jørgensen Morten
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2020005366A publication Critical patent/MX2020005366A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Addiction (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona compuestos de la fórmula (I), que son profármacos de catecolamina para uso en el tratamiento de enfermedades y trastornos neurodegenerativos. La presente invención proporciona también composiciones farmacéuticas que comprenden compuestos de la invención y métodos de tratar enfermedades y trastornos neurodegenerativos o neuropsiquiátricos utilizando los compuestos de la invención, en particular la enfermedad de Parkinson. Por consiguiente, la presente invención se relaciona con compuestos de la fórmula (Id) en donde R1 es H y R2 se selecciona de uno de los sustituyentes (i) y (ii) más adelante; o R1 se selecciona de uno de los sustituyentes (i) y (ii) más adelante y R2 es H; o R1 y R2 se representan ambos por el sustituyente (i) más adelante; o R1 y R2 se representan ambos por el sustituyente (ii) más adelante; o R1 es sustituyente (i) y R2 es sustituyente (ii); o R1 es sustituyente (ii) y R2 es sustituyente (i); en donde * indica el punto de unión; y en donde el átomo de carbono en el punto de unión en el sustituyente (i) está en la configuración S; o una sal farmacéuticamente aceptable del mismo.
MX2020005366A 2017-11-24 2018-11-23 Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson. MX2020005366A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700674 2017-11-24
PCT/EP2018/082361 WO2019101917A1 (en) 2017-11-24 2018-11-23 New catecholamine prodrugs for use in the treatment of parkinson's disease

Publications (1)

Publication Number Publication Date
MX2020005366A true MX2020005366A (es) 2020-08-13

Family

ID=64661284

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020005366A MX2020005366A (es) 2017-11-24 2018-11-23 Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson.
MX2022016276A MX2022016276A (es) 2017-11-24 2020-07-13 Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022016276A MX2022016276A (es) 2017-11-24 2020-07-13 Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson.

Country Status (25)

Country Link
US (5) US10729710B2 (es)
EP (1) EP3713933B1 (es)
JP (4) JP7320507B2 (es)
KR (1) KR102712887B1 (es)
CN (3) CN111386267B (es)
AR (1) AR113908A1 (es)
AU (2) AU2018371193B2 (es)
BR (1) BR112019014981A2 (es)
CA (1) CA3082757A1 (es)
CL (1) CL2020001343A1 (es)
CO (1) CO2020006224A2 (es)
CR (1) CR20200225A (es)
EA (1) EA202090987A8 (es)
EC (1) ECSP20030074A (es)
GE (2) GEAP202215342A (es)
IL (1) IL274648B2 (es)
JO (2) JOP20200114B1 (es)
MA (1) MA50800A (es)
MX (2) MX2020005366A (es)
PE (1) PE20211290A1 (es)
PH (1) PH12020550631A1 (es)
SG (1) SG11202004461YA (es)
TW (1) TWI816716B (es)
UA (1) UA127575C2 (es)
WO (1) WO2019101917A1 (es)

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Publication number Priority date Publication date Assignee Title
CR20200225A (es) * 2017-11-24 2020-07-25 H Lundbeck As Nuevos fármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson
US11130775B2 (en) * 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
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WO2025078574A1 (en) 2023-10-12 2025-04-17 Integrative Research Laboratories Sweden Ab NOVEL ESTERS OF 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[g]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF

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Publication number Publication date
JP7443606B2 (ja) 2024-03-05
US20200338102A1 (en) 2020-10-29
PE20211290A1 (es) 2021-07-20
CN111386267B (zh) 2023-12-12
EP3713933B1 (en) 2026-03-25
US11707476B2 (en) 2023-07-25
NZ764717A (en) 2024-08-30
CN117653649A (zh) 2024-03-08
AU2023201741A1 (en) 2023-04-20
JP2023145580A (ja) 2023-10-11
JOP20200114A1 (ar) 2020-05-17
TWI816716B (zh) 2023-10-01
IL274648B1 (en) 2024-06-01
EP3713933A1 (en) 2020-09-30
JP2023055830A (ja) 2023-04-18
EA202090987A1 (ru) 2020-08-07
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