MX2020005544A - Metodo para preparar acetato de salicilamina. - Google Patents

Metodo para preparar acetato de salicilamina.

Info

Publication number
MX2020005544A
MX2020005544A MX2020005544A MX2020005544A MX2020005544A MX 2020005544 A MX2020005544 A MX 2020005544A MX 2020005544 A MX2020005544 A MX 2020005544A MX 2020005544 A MX2020005544 A MX 2020005544A MX 2020005544 A MX2020005544 A MX 2020005544A
Authority
MX
Mexico
Prior art keywords
preparing
formula
structure represented
compound
salicylamine acetate
Prior art date
Application number
MX2020005544A
Other languages
English (en)
Inventor
Ling Long
Original Assignee
Tsi Pharmaceutical Jiangyin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsi Pharmaceutical Jiangyin Co Ltd filed Critical Tsi Pharmaceutical Jiangyin Co Ltd
Publication of MX2020005544A publication Critical patent/MX2020005544A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/22—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of other functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describe un método para preparar acetato de salicilamina. El método comprende las etapas de: (1) llevar a cabo la protección de amino en salicilaldehído que tiene una estructura representada por la fórmula 1 para obtener un compuesto que tiene una estructura representada por la fórmula 2; y (2) llevar a cabo la hidrólisis ácida al compuesto que tiene una estructura representada por la fórmula 2 y luego hacer reaccionar el compuesto hidrolizado en ácido, con ácido 0 acético para obtener acetato de salicilamina.
MX2020005544A 2017-11-28 2018-11-26 Metodo para preparar acetato de salicilamina. MX2020005544A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201711221319.7A CN109836341B (zh) 2017-11-28 2017-11-28 一种水杨胺醋酸盐的制备方法
PCT/CN2018/117458 WO2019105324A1 (zh) 2017-11-28 2018-11-26 一种水杨胺醋酸盐的制备方法

Publications (1)

Publication Number Publication Date
MX2020005544A true MX2020005544A (es) 2022-11-28

Family

ID=66664336

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005544A MX2020005544A (es) 2017-11-28 2018-11-26 Metodo para preparar acetato de salicilamina.

Country Status (11)

Country Link
US (1) US11512044B2 (es)
EP (1) EP3719002B8 (es)
JP (1) JP7454498B2 (es)
KR (1) KR102706812B1 (es)
CN (1) CN109836341B (es)
AU (1) AU2018377588B2 (es)
BR (1) BR112020010618B1 (es)
CA (1) CA3083618A1 (es)
MX (1) MX2020005544A (es)
MY (1) MY201283A (es)
WO (1) WO2019105324A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020212612B2 (en) 2019-01-25 2025-07-31 Naji Abumrad Triphenylphosphonium-tethered salicylamine derivatives
CN111978185B (zh) * 2019-05-24 2022-03-22 技源集团股份有限公司 一种水杨胺醋酸盐的制备方法
CN118221551A (zh) * 2024-04-10 2024-06-21 南京艾康生物科技有限公司 4-甲酰苄基氨基甲酸叔丁酯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55162747A (en) * 1979-06-07 1980-12-18 Ono Pharmaceut Co Ltd 2-aminomethylphenol derivative and its preparation
US6117880A (en) * 1997-10-30 2000-09-12 Merck & Co., Inc. Somatostatin agonists
CN101774927A (zh) * 2010-02-01 2010-07-14 重庆市春瑞医药化工有限公司 一种二苄基乙二胺及其醋酸盐的制备方法
EP3312176A1 (en) * 2011-02-01 2018-04-25 Emergent Product Development Gaithersburg Inc. Antimicrobial 4-oxoquinolizines
US10975033B2 (en) * 2011-07-12 2021-04-13 Vanderbilt University Methods for treating inflammation and hypertension with γ-ketoaldehyde skavengers
CN102675143A (zh) * 2012-06-05 2012-09-19 自贡鸿鹤化工股份有限公司 乙水杨胺的合成方法
CN106496182B (zh) * 2016-09-09 2019-07-05 复旦大学 一种阿托伐他汀测链中间体的制备方法

Also Published As

Publication number Publication date
MY201283A (en) 2024-02-15
AU2018377588B2 (en) 2024-06-06
EP3719002B1 (en) 2023-01-04
EP3719002A1 (en) 2020-10-07
JP2021504458A (ja) 2021-02-15
CA3083618A1 (en) 2019-06-06
KR20200103693A (ko) 2020-09-02
BR112020010618B1 (pt) 2023-12-26
EP3719002A4 (en) 2021-09-29
JP7454498B2 (ja) 2024-03-22
BR112020010618A2 (pt) 2020-11-10
US11512044B2 (en) 2022-11-29
AU2018377588A1 (en) 2020-07-16
KR102706812B1 (ko) 2024-09-12
CN109836341A (zh) 2019-06-04
CN109836341B (zh) 2021-08-27
WO2019105324A1 (zh) 2019-06-06
EP3719002B8 (en) 2023-04-05
US20210053907A1 (en) 2021-02-25
EP3719002A9 (en) 2021-11-10

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