MX2020006042A - Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas. - Google Patents

Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas.

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Publication number
MX2020006042A
MX2020006042A MX2020006042A MX2020006042A MX2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A
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Mexico
Prior art keywords
colon cancer
mtor inhibitor
methods
combination therapy
inhibitor combination
Prior art date
Application number
MX2020006042A
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English (en)
Inventor
Neil P Desai
Original Assignee
Abraxis Bioscience Llc
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Publication date
Application filed by Abraxis Bioscience Llc filed Critical Abraxis Bioscience Llc
Publication of MX2020006042A publication Critical patent/MX2020006042A/es

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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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Abstract

La presente solicitud proporciona métodos para tratar un cáncer de colon (tal como el cáncer de colon avanzado y/o metastásico) en un individuo, que comprenden administrar al individuo: a) una cantidad efectiva de una composición que comprende nanopartículas que comprenden un inhibidor de Mtor (tal como un fármaco tipo limus, tal como sirolimus o un derivado del mismo) y una albúmina, b) una cantidad efectiva de anticuerpo anti-VEGF (tal como bevacizumab), y c) un régimen de FOLFOX terapéuticamente efectivo (tal como FOLFOX4 o un FOLFOX6 modificado).
MX2020006042A 2017-12-19 2018-12-18 Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas. MX2020006042A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762607798P 2017-12-19 2017-12-19
PCT/US2018/066309 WO2019126223A1 (en) 2017-12-19 2018-12-18 Methods of treating colon cancer using nanoparticle mtor inhibitor combination therapy

Publications (1)

Publication Number Publication Date
MX2020006042A true MX2020006042A (es) 2020-10-20

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MX2020006042A MX2020006042A (es) 2017-12-19 2018-12-18 Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas.

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US (2) US20190184031A1 (es)
EP (1) EP3727368A4 (es)
JP (1) JP2021506839A (es)
KR (1) KR20200101396A (es)
CN (1) CN111683657A (es)
AU (1) AU2018388579A1 (es)
BR (1) BR112020012060A2 (es)
CA (1) CA3084994A1 (es)
EA (1) EA202091514A1 (es)
IL (1) IL275261A (es)
MX (1) MX2020006042A (es)
SG (1) SG11202005613SA (es)
WO (1) WO2019126223A1 (es)

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PT2117520T (pt) 2006-12-14 2018-12-04 Abraxis Bioscience Llc Terapia do cancro da mama com base no estado do receptor do hormona com nanoparticulas compreendendo taxane
PT2790675T (pt) 2011-12-14 2019-09-23 Abraxis Bioscience Llc Utilização de excipientes poliméricos para a liofilização ou a congelação de partículas
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
EP3313401B1 (en) 2015-06-29 2021-10-06 Abraxis BioScience, LLC Nanoparticles comprising sirolimus and an albumin for use in treating epithelioid cell tumors
IL277402B1 (en) 2018-03-20 2026-04-01 Abraxis Bioscience Llc Methods for treating central nervous system disorders using administration of MTOR inhibitor nanoparticles and albumin
KR20220106758A (ko) 2019-10-28 2022-07-29 아브락시스 바이오사이언스, 엘엘씨 알부민 및 라파마이신의 제약 조성물
WO2021096997A1 (en) * 2019-11-11 2021-05-20 Abraxis Bioscience, Llc Biomarkers for nanoparticle compositions
EP4058000A4 (en) * 2019-11-11 2024-02-28 Abraxis BioScience, LLC BIOMARKERS FOR NANOPARTICLE COMPOSITIONS
US20230173067A1 (en) * 2020-05-29 2023-06-08 Seagen Inc. Methods of treating her2 positive cancer with tucatinib in combination with trastuzumab and an oxaliplatin-based chemotherapy
JP2023536636A (ja) * 2020-08-03 2023-08-28 オンコサイト・コーポレイション 腫瘍の分類及び応答性の予測
CN113925975B (zh) * 2021-08-31 2024-05-28 杭州师范大学 p53及UTX信使RNA纳米粒的制备方法及该信使RNA的应用
EP4473313A2 (en) * 2022-02-02 2024-12-11 Oncocyte Corporation Classifying tumors and predicting responsiveness
CN114702552B (zh) * 2022-03-11 2024-05-31 苏州思萃免疫技术研究所有限公司 mTORC2抑制剂
CN118109588B (zh) * 2024-01-25 2024-10-01 暨南大学附属第一医院（广州华侨医院） Nprl2作为靶点在癌症放疗增敏中的应用
CN118064595B (zh) * 2024-04-17 2024-08-02 中山大学附属第六医院 一种预测结直肠癌肝转移的生物标志物及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166388A1 (en) * 2005-02-18 2007-07-19 Desai Neil P Combinations and modes of administration of therapeutic agents and combination therapy
LT2481402T (lt) * 2007-03-07 2018-10-25 Abraxis Bioscience, Llc Nanodalelė, apimanti rapamiciną ir albuminą, kaip priešvėžinį agentą
DE102011100122A1 (de) * 2011-04-26 2012-10-31 Eurocor Gmbh Katheterballon beschichtet mit Rapamycin und Schellack
CA2990726A1 (en) * 2015-06-29 2017-01-05 Abraxis Bioscience, Llc Methods of treating solid tumors using nanoparticle mtor inhibitor combination therapy

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EP3727368A4 (en) 2021-10-20
IL275261A (en) 2020-07-30
US20240009323A1 (en) 2024-01-11
AU2018388579A1 (en) 2020-07-09
SG11202005613SA (en) 2020-07-29
BR112020012060A2 (pt) 2020-11-24
EA202091514A1 (ru) 2020-09-15
CA3084994A1 (en) 2019-06-27
US20190184031A1 (en) 2019-06-20
JP2021506839A (ja) 2021-02-22
CN111683657A (zh) 2020-09-18
EP3727368A1 (en) 2020-10-28
KR20200101396A (ko) 2020-08-27
WO2019126223A1 (en) 2019-06-27

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