MX2020006098A - Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano. - Google Patents
Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano.Info
- Publication number
- MX2020006098A MX2020006098A MX2020006098A MX2020006098A MX2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A
- Authority
- MX
- Mexico
- Prior art keywords
- lysins
- derivatives
- identification
- gram
- activity against
- Prior art date
Links
- 241000589517 Pseudomonas aeruginosa Species 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describen nuevos polipéptidos de lisina activos contra bacterias Gramnegativas, particularmente P. aeruginosa, composiciones farmacéuticas que los contienen y métodos para su uso para tratar infecciones bacterianas Gramnegativas y, más generalmente para inhibir el crecimiento, o reducir la población, o matar bacterias Gramnegativas, incluyendo, pero sin limitarse a, alterar las biopelículas formadas por dichas bacterias. Algunas de las lisinas descritas se han modificado en la secuencia de aminoácidos en comparación con la de las lisinas mediante el reemplazo de ciertos aminoácidos cargados con aminoácidos no cargados y/o mediante fusión en la terminal N- o C- con secuencias de péptidos antibacterianos con o sin un en lazador de intervención.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762597577P | 2017-12-12 | 2017-12-12 | |
| US201862721969P | 2018-08-23 | 2018-08-23 | |
| PCT/US2018/065265 WO2019118632A1 (en) | 2017-12-12 | 2018-12-12 | Identification of lysins and derivatives thereof with bacterial activity against pseudomonas aeruginosa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020006098A true MX2020006098A (es) | 2020-08-24 |
Family
ID=66819724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020006098A MX2020006098A (es) | 2017-12-12 | 2018-12-12 | Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12121568B2 (es) |
| EP (1) | EP3723789A4 (es) |
| JP (2) | JP2021506769A (es) |
| KR (1) | KR20200098615A (es) |
| CN (1) | CN111971058A (es) |
| AU (1) | AU2018384790C1 (es) |
| BR (1) | BR112020011433A2 (es) |
| CA (1) | CA3085644A1 (es) |
| IL (2) | IL303122A (es) |
| MX (1) | MX2020006098A (es) |
| WO (1) | WO2019118632A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020011433A2 (pt) | 2017-12-12 | 2020-12-01 | Contrafect Corporation | identificação de lisinas e seus derivados com atividade bacteriana contra pseudomonas aeruginosa |
| WO2019126670A1 (en) * | 2017-12-22 | 2019-06-27 | The Rockefeller University | Recombinant pseudomonas aeruginosa lysins |
| CN112368376A (zh) | 2018-03-29 | 2021-02-12 | 康特拉费克特公司 | 溶素-抗微生物肽(amp)多肽构建体、溶素、其分离的编码多核苷酸及其用途 |
| US10988520B2 (en) * | 2018-03-29 | 2021-04-27 | Contrafect Corporation | Lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| WO2020046747A1 (en) * | 2018-08-23 | 2020-03-05 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| EP3946609A4 (en) * | 2019-04-05 | 2023-05-03 | Contrafect Corporation | LYSINE AND ITS DERIVATIVES WITH BACTERICIDAL ACTIVITY AGAINST PSEUDOMONAS AERUGINOSA IN THE PRESENCE OF HUMAN SERUM |
| KR102225240B1 (ko) * | 2019-07-03 | 2021-03-10 | 경북대학교 산학협력단 | 다제내성 병원성 세균을 효과적으로 사멸시키는 재조합 항균 단백질 Ablysin의 용도 |
| US20220411473A1 (en) * | 2019-11-14 | 2022-12-29 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| WO2023034646A2 (en) * | 2021-09-03 | 2023-03-09 | Aanika Biosciences, Inc. | Lysecd7 variants and methods of using the same |
| CN114410670B (zh) * | 2022-01-29 | 2024-01-23 | 福建医科大学附属口腔医院 | 一种溶菌酶及其在口腔护理用品中的应用 |
| CN117660413B (zh) * | 2023-12-15 | 2024-06-07 | 华南理工大学 | 一种内溶素Lys009及其工程改造和应用 |
| CN120173923A (zh) * | 2025-05-08 | 2025-06-20 | 浙江大学 | 与PeiR裂解酶高维特征同源的产甲烷菌裂解酶及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0815484D0 (en) * | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| JP5701777B2 (ja) | 2009-02-06 | 2015-04-15 | テクノファージ， インベスティガサン エ デセンボルビメント エム ビオテクノロジア，エスエー | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
| CA2780079A1 (en) | 2009-11-18 | 2011-05-26 | Basf Plant Science Company Gmbh | Process for the production of fine chemicals |
| EA037276B1 (ru) | 2010-04-27 | 2021-03-03 | Лисандо Аг | Способы устранения или уменьшения бактериальной биопленки |
| GB201018518D0 (en) | 2010-11-03 | 2010-12-15 | Univ Leuven Kath | Novel endolysin |
| CA2833409A1 (en) | 2011-04-21 | 2012-10-26 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| WO2015070912A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| AU2015279705B2 (en) | 2014-06-26 | 2021-04-01 | The Rockefeller University | Acinetobacter lysins |
| AU2016324307B2 (en) * | 2015-09-17 | 2021-10-21 | Contrafect Corporation | Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby |
| BR112020011433A2 (pt) | 2017-12-12 | 2020-12-01 | Contrafect Corporation | identificação de lisinas e seus derivados com atividade bacteriana contra pseudomonas aeruginosa |
| CN108103050A (zh) | 2018-02-11 | 2018-06-01 | 中国医药集团总公司四川抗菌素工业研究所 | 一种铜绿假单胞菌噬菌体裂解酶、其编码基因、重组表达载体及其制备方法和应用 |
| CN112368376A (zh) | 2018-03-29 | 2021-02-12 | 康特拉费克特公司 | 溶素-抗微生物肽(amp)多肽构建体、溶素、其分离的编码多核苷酸及其用途 |
| WO2020046747A1 (en) | 2018-08-23 | 2020-03-05 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
-
2018
- 2018-12-12 BR BR112020011433-2A patent/BR112020011433A2/pt not_active Application Discontinuation
- 2018-12-12 EP EP18889220.2A patent/EP3723789A4/en not_active Withdrawn
- 2018-12-12 AU AU2018384790A patent/AU2018384790C1/en active Active
- 2018-12-12 JP JP2020531748A patent/JP2021506769A/ja active Pending
- 2018-12-12 WO PCT/US2018/065265 patent/WO2019118632A1/en not_active Ceased
- 2018-12-12 CN CN201880089186.9A patent/CN111971058A/zh active Pending
- 2018-12-12 MX MX2020006098A patent/MX2020006098A/es unknown
- 2018-12-12 US US16/772,001 patent/US12121568B2/en active Active
- 2018-12-12 KR KR1020207020090A patent/KR20200098615A/ko not_active Ceased
- 2018-12-12 CA CA3085644A patent/CA3085644A1/en active Pending
- 2018-12-12 IL IL303122A patent/IL303122A/en unknown
- 2018-12-12 IL IL275060A patent/IL275060B2/en unknown
-
2023
- 2023-10-20 JP JP2023181425A patent/JP7646237B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018384790C1 (en) | 2025-05-01 |
| IL275060B2 (en) | 2023-10-01 |
| BR112020011433A2 (pt) | 2020-12-01 |
| WO2019118632A1 (en) | 2019-06-20 |
| CN111971058A (zh) | 2020-11-20 |
| KR20200098615A (ko) | 2020-08-20 |
| US12121568B2 (en) | 2024-10-22 |
| AU2018384790A1 (en) | 2020-07-30 |
| JP7646237B2 (ja) | 2025-03-17 |
| RU2020118691A (ru) | 2022-01-13 |
| IL275060B1 (en) | 2023-06-01 |
| IL303122A (en) | 2023-07-01 |
| CA3085644A1 (en) | 2019-06-20 |
| EP3723789A1 (en) | 2020-10-21 |
| JP2021506769A (ja) | 2021-02-22 |
| EP3723789A4 (en) | 2021-12-01 |
| AU2018384790B2 (en) | 2024-10-17 |
| US20210085758A1 (en) | 2021-03-25 |
| JP2024010053A (ja) | 2024-01-23 |
| IL275060A (en) | 2020-07-30 |
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