MX2020006843A - Nanoparticula de lipido que contiene acido nucleico y uso de la misma. - Google Patents

Nanoparticula de lipido que contiene acido nucleico y uso de la misma.

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Publication number
MX2020006843A
MX2020006843A MX2020006843A MX2020006843A MX2020006843A MX 2020006843 A MX2020006843 A MX 2020006843A MX 2020006843 A MX2020006843 A MX 2020006843A MX 2020006843 A MX2020006843 A MX 2020006843A MX 2020006843 A MX2020006843 A MX 2020006843A
Authority
MX
Mexico
Prior art keywords
particle
vivo
nucleic acid
lipid nano
containing lipid
Prior art date
Application number
MX2020006843A
Other languages
English (en)
Inventor
Satoru Matsumoto
Shinobu Kuwae
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MX2020006843A publication Critical patent/MX2020006843A/es

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Abstract

La presente invención provee una nanopartícula de lípido que contiene lo siguiente, (a) a (c): (a) un ácido nucleico que codifica un receptor de antígeno quimérico (CAR) o un receptor de células T exógeno (TCR); (b) un lípido catiónico; y (c) un lípido no catiónico. La presente invención también provee un inmunocito que expresa CAR o TCR exógeno, obtenido introduciendo la nanopartícula de lípido en células T in vivo o ex vivo, y una estrategia terapéutica in vivo o ex vivo usando los inmunocitos para enfermedades tales como el cáncer, etc.
MX2020006843A 2017-12-27 2018-12-26 Nanoparticula de lipido que contiene acido nucleico y uso de la misma. MX2020006843A (es)

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