MX2020007391A - Nuevo galactosido inhibidor de galectinas. - Google Patents
Nuevo galactosido inhibidor de galectinas.Info
- Publication number
- MX2020007391A MX2020007391A MX2020007391A MX2020007391A MX2020007391A MX 2020007391 A MX2020007391 A MX 2020007391A MX 2020007391 A MX2020007391 A MX 2020007391A MX 2020007391 A MX2020007391 A MX 2020007391A MX 2020007391 A MX2020007391 A MX 2020007391A
- Authority
- MX
- Mexico
- Prior art keywords
- galectins
- formula
- galectin
- sup
- compound
- Prior art date
Links
- 102000007563 Galectins Human genes 0.000 title abstract 2
- 108010046569 Galectins Proteins 0.000 title abstract 2
- 150000008195 galaktosides Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000000795 Galectin 1 Human genes 0.000 abstract 1
- 108010001498 Galectin 1 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 150000003214 pyranose derivatives Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención se refiere a un compuesto de la fórmula general (1). El compuesto de la fórmula (1) es adecuado para el uso en un método para tratar un trastorno relacionado con la unión de una galectina, tal comogalectina-1 a un ligando en un mamífero, tal como un humano. Además, la presente invención se refiere a un método para el tratamiento de un trastorno relacionado con la unión de una galectina, tal como galectina-1 a un ligando en un mamífero, tal como un humano.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18150959 | 2018-01-10 | ||
| PCT/EP2019/050467 WO2019137971A1 (en) | 2018-01-10 | 2019-01-09 | Novel galactoside inhibitor of galectins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020007391A true MX2020007391A (es) | 2020-09-03 |
Family
ID=60953765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007391A MX2020007391A (es) | 2018-01-10 | 2019-01-09 | Nuevo galactosido inhibidor de galectinas. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11046725B2 (es) |
| EP (1) | EP3737686A1 (es) |
| JP (1) | JP2021510692A (es) |
| KR (1) | KR20200108303A (es) |
| CN (1) | CN111699193A (es) |
| BR (1) | BR112020013647A2 (es) |
| CA (1) | CA3086092A1 (es) |
| EA (1) | EA202091684A1 (es) |
| MX (1) | MX2020007391A (es) |
| WO (1) | WO2019137971A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2970062C (en) | 2015-01-30 | 2023-02-28 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| CN111699193A (zh) * | 2018-01-10 | 2020-09-22 | 格莱克特生物技术公司 | 新型半乳糖苷类半乳凝素抑制剂 |
| CN113366007A (zh) * | 2018-10-15 | 2021-09-07 | 格莱克特生物技术公司 | 半乳糖凝集素的半乳糖苷抑制剂 |
| EP3983423A4 (en) | 2019-06-14 | 2023-07-19 | Université Laval | SYNTHESIS OF 3-AZIDO-3-DEOXY-D-GALACTOPYRANOSE |
| JP7674276B2 (ja) * | 2019-07-03 | 2025-05-09 | ガレクト バイオテック エービー | ガレクチンの新規なガラクトシド阻害剤 |
| TW202134214A (zh) * | 2020-03-04 | 2021-09-16 | 瑞士商先正達農作物保護公司 | 用於製備具有3-含硫取代基的5-氯-吡啶-2-甲酸醯胺以及甲酸鹽之方法 |
| WO2025180907A1 (en) * | 2024-02-26 | 2025-09-04 | Galecto Biotech Ab | Specific galactoside inhibitor of galectin-1 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6849607B2 (en) | 2001-05-09 | 2005-02-01 | Health Research, Inc. | Galectin recognized photosensitizers for photodynamic therapy |
| SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel Galactoside Inhibitors of Galectins |
| SE0401301D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel 3-triazolyl-galactoside inhibitors of galectins |
| ES2652488T3 (es) | 2009-04-28 | 2018-02-02 | Galecto Biotech Ab | Nuevos inhibidores de galactósidos de galectinas |
| KR102231732B1 (ko) | 2012-10-10 | 2021-03-23 | 갈렉틴 테라퓨틱스, 인크. | 당뇨병성 신장병증 및 관련 질환의 치료를 위한 갈락토스 갈래의 탄수화물 화합물 |
| IN2015DN02573A (es) | 2012-10-31 | 2015-09-11 | Galecto Biotech Ab | |
| WO2016113335A1 (en) * | 2015-01-16 | 2016-07-21 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
| CA2970062C (en) * | 2015-01-30 | 2023-02-28 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| CN109563120B (zh) | 2016-07-12 | 2022-12-02 | 格莱克特生物技术公司 | 半乳糖凝集素的α-D-半乳糖苷抑制剂 |
| CN109563119A (zh) * | 2016-07-12 | 2019-04-02 | 格莱克特生物技术公司 | 半乳糖凝集素的α-D-半乳糖苷抑制剂 |
| CN111699193A (zh) * | 2018-01-10 | 2020-09-22 | 格莱克特生物技术公司 | 新型半乳糖苷类半乳凝素抑制剂 |
-
2019
- 2019-01-09 CN CN201980007910.3A patent/CN111699193A/zh active Pending
- 2019-01-09 CA CA3086092A patent/CA3086092A1/en active Pending
- 2019-01-09 BR BR112020013647-6A patent/BR112020013647A2/pt not_active Application Discontinuation
- 2019-01-09 MX MX2020007391A patent/MX2020007391A/es unknown
- 2019-01-09 EA EA202091684A patent/EA202091684A1/ru unknown
- 2019-01-09 US US16/960,996 patent/US11046725B2/en active Active
- 2019-01-09 JP JP2020538084A patent/JP2021510692A/ja active Pending
- 2019-01-09 WO PCT/EP2019/050467 patent/WO2019137971A1/en not_active Ceased
- 2019-01-09 KR KR1020207022591A patent/KR20200108303A/ko not_active Withdrawn
- 2019-01-09 EP EP19700281.9A patent/EP3737686A1/en not_active Withdrawn
-
2021
- 2021-05-24 US US17/327,954 patent/US11827666B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3737686A1 (en) | 2020-11-18 |
| KR20200108303A (ko) | 2020-09-17 |
| BR112020013647A2 (pt) | 2020-12-01 |
| US20200347089A1 (en) | 2020-11-05 |
| CA3086092A1 (en) | 2019-07-18 |
| US20210284678A1 (en) | 2021-09-16 |
| CN111699193A (zh) | 2020-09-22 |
| US11046725B2 (en) | 2021-06-29 |
| WO2019137971A1 (en) | 2019-07-18 |
| EA202091684A1 (ru) | 2020-12-04 |
| JP2021510692A (ja) | 2021-04-30 |
| US11827666B2 (en) | 2023-11-28 |
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