MX2020008073A - Biocatalizador y metodos para sintetizar conjugados mezclados de disulfuro de compuestos de tienopiridina. - Google Patents

Biocatalizador y metodos para sintetizar conjugados mezclados de disulfuro de compuestos de tienopiridina.

Info

Publication number
MX2020008073A
MX2020008073A MX2020008073A MX2020008073A MX2020008073A MX 2020008073 A MX2020008073 A MX 2020008073A MX 2020008073 A MX2020008073 A MX 2020008073A MX 2020008073 A MX2020008073 A MX 2020008073A MX 2020008073 A MX2020008073 A MX 2020008073A
Authority
MX
Mexico
Prior art keywords
methods
biocatalyst
mixed disulfide
disulfide conjugates
thienopyridine compounds
Prior art date
Application number
MX2020008073A
Other languages
English (en)
Inventor
Haoming Zhang
Original Assignee
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of MX2020008073A publication Critical patent/MX2020008073A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/003—Catalysts comprising hydrides, coordination complexes or organic compounds containing enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
    • C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona con métodos para sintetizar conjugados mezclados de disulfuro de compuestos de tienopiridina con una variante diseñada genéticamente del citocromo P450 de BM3 o CYP102A1 como un catalizador, y pertenece al campo de la síntesis química.
MX2020008073A 2018-01-31 2019-01-31 Biocatalizador y metodos para sintetizar conjugados mezclados de disulfuro de compuestos de tienopiridina. MX2020008073A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862624494P 2018-01-31 2018-01-31
PCT/US2019/016099 WO2019152679A1 (en) 2018-01-31 2019-01-31 Biocatalyst and methods for synthesizing mixed disulfide conjugates of thienopyridine compounds

Publications (1)

Publication Number Publication Date
MX2020008073A true MX2020008073A (es) 2020-11-13

Family

ID=67478908

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008073A MX2020008073A (es) 2018-01-31 2019-01-31 Biocatalizador y metodos para sintetizar conjugados mezclados de disulfuro de compuestos de tienopiridina.

Country Status (12)

Country Link
US (2) US12188069B2 (es)
EP (1) EP3746551A4 (es)
JP (2) JP7485367B2 (es)
KR (1) KR102903740B1 (es)
CN (1) CN111699248B (es)
AU (1) AU2019215050B2 (es)
CA (1) CA3089861A1 (es)
EA (1) EA202091702A1 (es)
IL (1) IL276404A (es)
MX (1) MX2020008073A (es)
SG (1) SG11202007273WA (es)
WO (1) WO2019152679A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102903740B1 (ko) 2018-01-31 2025-12-24 더 리젠츠 오브 더 유니버시티 오브 미시간 티에노피리딘 화합물의 혼합된 이황화물 접합체를 합성하기 위한 생체촉매 및 방법
CN115327004B (zh) * 2022-08-12 2024-01-26 成都施贝康生物医药科技有限公司 一种氧化氯吡格雷粗品的检测方法

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US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4444762A (en) 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
RU2203887C2 (ru) 1998-02-27 2003-05-10 Санкио Компани, Лимитед Циклические аминопроизводные, фармацевтическая композиция и способ профилактики заболевания
US7435570B2 (en) 2003-08-11 2008-10-14 California Institute Of Technology Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use
GB0719620D0 (en) * 2007-10-08 2007-11-14 Isis Innovation Mutant Enzymes
KR101048475B1 (ko) 2008-12-03 2011-07-11 전남대학교산학협력단 박테리아 사이토크롬 피450을 이용한 피세아타놀의 신규한 생산방법 및 이를 위한 조성물
KR101190881B1 (ko) 2009-08-24 2012-10-12 전남대학교산학협력단 박테리아 사이토크롬 피450을 이용한 심바스타틴 또는 로바스타틴의 사람에서의 대사산물의 신규한 생산방법 및 이를 위한 조성물
CN102863457B (zh) 2010-02-02 2013-10-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
MX344435B (es) 2011-06-27 2016-12-14 Ipca Laboratories Ltd * Compuestos antitromboticos.
WO2013076258A2 (en) 2011-11-23 2013-05-30 Dsm Ip Assets B.V. P450 bm3 mutants and their use for regio- and stereoselective hydroxylation of alpha-and beta-ionone
KR101348984B1 (ko) 2012-01-31 2014-01-10 전남대학교산학협력단 박테리아 시토크롬 ｐ450을 이용한 오메프라졸로부터 대사산물의 신규한 생산방법 및 이를 위한 조성물
JP2015534464A (ja) * 2012-10-09 2015-12-03 カリフォルニア インスティチュート オブ テクノロジー ヘム酵素によって触媒されるインビボおよびインビトロオレフィンシクロプロパン化
SG11201505283RA (en) * 2013-01-09 2015-08-28 Univ Michigan Mixed disulfide conjugates of thienopyridine compounds and uses thereof
US9909145B2 (en) * 2013-09-19 2018-03-06 Firmenich Sa Method for producing fragrant alcohols
US20160032330A1 (en) 2014-06-05 2016-02-04 California Institute Of Technology P-450-catalyzed enantioselective cyclopropanation of electron-deficient olefins
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MX371538B (es) 2015-04-30 2020-01-30 Univ Michigan Regents Conjugados mezclados de disulfuro de compuestos de tienopiridina y usos de los mismos.
KR101719678B1 (ko) 2015-09-07 2017-03-24 전남대학교산학협력단 5'-하이드록시 오메프라졸 설파이드 제조용 조성물
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WO2019040335A1 (en) 2017-08-19 2019-02-28 University Of Rochester MICHELOLID DERIVATIVES, PREPARATION METHODS AND THEIR USE AS ANTICANCER AND ANTI-INFLAMMATORY AGENTS
KR102903740B1 (ko) 2018-01-31 2025-12-24 더 리젠츠 오브 더 유니버시티 오브 미시간 티에노피리딘 화합물의 혼합된 이황화물 접합체를 합성하기 위한 생체촉매 및 방법

Also Published As

Publication number Publication date
AU2019215050B2 (en) 2025-06-05
JP2024041908A (ja) 2024-03-27
JP2021511800A (ja) 2021-05-13
KR102903740B1 (ko) 2025-12-24
EP3746551A4 (en) 2021-11-03
KR20200115559A (ko) 2020-10-07
CN111699248B (zh) 2024-05-24
EP3746551A1 (en) 2020-12-09
US12188069B2 (en) 2025-01-07
AU2019215050A1 (en) 2020-09-03
CA3089861A1 (en) 2019-08-08
IL276404A (en) 2020-09-30
WO2019152679A1 (en) 2019-08-08
US20200370081A1 (en) 2020-11-26
JP7485367B2 (ja) 2024-05-16
SG11202007273WA (en) 2020-08-28
EA202091702A1 (ru) 2021-02-24
CN111699248A (zh) 2020-09-22
US20250146035A1 (en) 2025-05-08

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