MX2020009939A - Metodos para tratar el sindrome de prader-willi. - Google Patents

Metodos para tratar el sindrome de prader-willi.

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Publication number
MX2020009939A
MX2020009939A MX2020009939A MX2020009939A MX2020009939A MX 2020009939 A MX2020009939 A MX 2020009939A MX 2020009939 A MX2020009939 A MX 2020009939A MX 2020009939 A MX2020009939 A MX 2020009939A MX 2020009939 A MX2020009939 A MX 2020009939A
Authority
MX
Mexico
Prior art keywords
methods
willi syndrome
treat prader
prader
treat
Prior art date
Application number
MX2020009939A
Other languages
English (en)
Inventor
Dieter Egli
Sara Cotter
Lisa Cole Burnett
Rudolph L Leibel
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of MX2020009939A publication Critical patent/MX2020009939A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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Abstract

La presente invención se refiere a métodos para regular la prohormona convertasa (PC1) y compuestos y tratamientos que aumentan los niveles de PC1, para tratar el síndrome de Prader-Willi (PWS).
MX2020009939A 2016-06-03 2018-11-30 Metodos para tratar el sindrome de prader-willi. MX2020009939A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662345133P 2016-06-03 2016-06-03
US201662375662P 2016-08-16 2016-08-16

Publications (1)

Publication Number Publication Date
MX2020009939A true MX2020009939A (es) 2021-01-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018014942A MX375277B (es) 2016-06-03 2017-06-02 Métodos para tratar el síndrome de prader-willi
MX2020009939A MX2020009939A (es) 2016-06-03 2018-11-30 Metodos para tratar el sindrome de prader-willi.

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MX2018014942A MX375277B (es) 2016-06-03 2017-06-02 Métodos para tratar el síndrome de prader-willi

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US (3) US10842775B2 (es)
EP (2) EP3831376A1 (es)
JP (2) JP7044768B2 (es)
KR (1) KR102478186B1 (es)
CN (1) CN109562092B (es)
AU (1) AU2017275652B2 (es)
BR (1) BR112018075039A2 (es)
CA (1) CA3026083C (es)
ES (1) ES2847126T3 (es)
IL (2) IL263412B (es)
MX (2) MX375277B (es)
RU (2) RU2748294C2 (es)
WO (1) WO2017210540A1 (es)
ZA (1) ZA201808607B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX375277B (es) * 2016-06-03 2025-03-06 Univ Columbia Métodos para tratar el síndrome de prader-willi
AU2018243749A1 (en) * 2017-03-31 2019-11-21 Epizyme, Inc. Methods of using EHMT2 inhibitors
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
WO2019161179A1 (en) * 2018-02-15 2019-08-22 Ovid Therapeutics Inc. Methods of treating developmental syndromes with pde10a inhibitors
US20200093884A1 (en) * 2018-09-20 2020-03-26 Mark C. Manning Stable intranasal formulations of carbetocin
CN111264851A (zh) * 2020-03-03 2020-06-12 河南省儿童医院郑州儿童医院 Pws综合征靶向替代保健食品及其制备方法
WO2022235818A2 (en) * 2021-05-04 2022-11-10 Virginia Tech Intellectual Properties, Inc. Conjugated linoleic acid supplementation for disease treatment
KR102973977B1 (ko) * 2021-11-26 2026-06-09 충남대학교산학협력단 알파-멜라노사이트 자극 호르몬의 펩티드 변이체 및 이의 용도

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3270301A (en) * 1999-11-13 2001-05-30 Icos Corporation Combined pde3 and pde4 inhibitor therapy for the treatment of obesity
WO2001079837A1 (en) * 2000-04-12 2001-10-25 Repligen Corporation Methylxanthines in the diagnosis and treatment of autistic disorder
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
WO2004096222A1 (en) * 2003-04-30 2004-11-11 Switch Biotech Ag Use of 1-(5-isoquinolinesulfonyl)homopiperazine, its active metabolites, isomers and salts for treating and preventing hypopigmentary disorders
TW200528455A (en) * 2003-12-19 2005-09-01 Bristol Myers Squibb Co Azabicyclic heterocycles as cannabinoid receptor modulators
WO2005086750A2 (en) 2004-03-06 2005-09-22 Irm Llc Prohormone convertase 1 mutation associated with obesity
US20060062859A1 (en) 2004-08-05 2006-03-23 Kenneth Blum Composition and method to optimize and customize nutritional supplement formulations by measuring genetic and metabolomic contributing factors to disease diagnosis, stratification, prognosis, metabolism, and therapeutic outcomes
US8927546B2 (en) * 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
CN101361754B (zh) 2007-08-09 2013-04-17 李凌松 稀土元素盐或其药物组合物在制备治疗或预防糖尿病和肥胖症药物中的用途
WO2010062681A2 (en) * 2008-10-30 2010-06-03 University Of South Florida Luteolin and diosmin/diosmetin as novel stat3 inhibitors for treating autism
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
WO2011083718A1 (ja) * 2010-01-05 2011-07-14 学校法人慶應義塾 肺再生促進剤
CA2835707C (en) 2011-05-09 2019-02-26 Eip Pharma, Llc Compositions and methods for treating alzheimer's disease
US20140364367A1 (en) * 2013-06-08 2014-12-11 Sedogen, Llc Methods of treating prader willi syndrome and conditions associated with low basal metabolic rate or hyperphagia using a katp channel opener
EP3096749B1 (en) * 2014-01-24 2019-05-15 Celgene Corporation Methods for the treatment of obesity using apremilast
KR102323613B1 (ko) * 2014-11-14 2021-11-09 에센셜리스 인코포레이티드 프라더-윌리 증후군 또는 스미스-마제니스 증후군을 가지는 대상체를 치료하는 방법
MX375277B (es) * 2016-06-03 2025-03-06 Univ Columbia Métodos para tratar el síndrome de prader-willi

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