MX2022010299A - Derivados macrocíclicos de indol como inhibidores de mcl-1. - Google Patents

Derivados macrocíclicos de indol como inhibidores de mcl-1.

Info

Publication number
MX2022010299A
MX2022010299A MX2022010299A MX2022010299A MX2022010299A MX 2022010299 A MX2022010299 A MX 2022010299A MX 2022010299 A MX2022010299 A MX 2022010299A MX 2022010299 A MX2022010299 A MX 2022010299A MX 2022010299 A MX2022010299 A MX 2022010299A
Authority
MX
Mexico
Prior art keywords
mcl
inhibitors
indole derivatives
macrocyclic indole
macrocyclic
Prior art date
Application number
MX2022010299A
Other languages
English (en)
Inventor
Adriana Ingrid Velter
Frederik Jan Rita Rombouts
Tristan Reuillon
Ann Marleen Vos
Aldo Peschiulli
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2022010299A publication Critical patent/MX2022010299A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o la profilaxis en un sujeto, una composición farmacéutica que comprende tales compuestos y su uso como inhibidores de MCL-1, útiles para tratar enfermedades tales como el cáncer.
MX2022010299A 2020-02-21 2021-02-18 Derivados macrocíclicos de indol como inhibidores de mcl-1. MX2022010299A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP20158764 2020-02-21
EP20169887 2020-04-16
EP20184956 2020-07-09
PCT/EP2021/053973 WO2021165370A1 (en) 2020-02-21 2021-02-18 Macrocyclic indole derivatives as inhibitors of mcl-1

Publications (1)

Publication Number Publication Date
MX2022010299A true MX2022010299A (es) 2022-11-14

Family

ID=74626012

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010299A MX2022010299A (es) 2020-02-21 2021-02-18 Derivados macrocíclicos de indol como inhibidores de mcl-1.

Country Status (10)

Country Link
US (1) US20230130109A1 (es)
EP (1) EP4107161A1 (es)
JP (1) JP2023514364A (es)
KR (1) KR20220143906A (es)
CN (1) CN115151551B (es)
AU (1) AU2021222332A1 (es)
BR (1) BR112022016444A2 (es)
CA (1) CA3168355A1 (es)
MX (1) MX2022010299A (es)
WO (1) WO2021165370A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230121807A (ko) * 2020-12-17 2023-08-21 얀센 파마슈티카 엔.브이. Mcl-1의 억제제로서의 분지형 매크로사이클릭 4-(피라졸-5-일)-인돌유도체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
SMT202000249T1 (it) * 2016-04-22 2020-07-08 Astrazeneca Ab Inibitori di mcl1 macrociclici per il trattamento di cancro
TWI781996B (zh) 2017-03-31 2022-11-01 瑞典商阿斯特捷利康公司 合成ｍｃｌ-１抑制劑之方法
TW201904976A (zh) * 2017-03-31 2019-02-01 瑞典商阿斯特捷利康公司 Ｍｃｌ-１抑制劑及其使用方法
AU2019347963A1 (en) * 2018-09-30 2021-05-27 Jiangsu Hengrui Medicine Co., Ltd. Indole macrocyclic derivative, preparation method therefor and application thereof in medicine
TWI749404B (zh) 2018-11-22 2021-12-11 大陸商蘇州亞盛藥業有限公司 作為mcl-1抑制劑的大環吲哚
US12319703B2 (en) * 2019-01-23 2025-06-03 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic fused pyrazoles as Mcl-1 inhibitors
US20220144854A1 (en) * 2019-03-08 2022-05-12 Zeno Management, Inc. Macrocyclic compounds
JP7617861B2 (ja) * 2019-06-21 2025-01-20 ヤンセン ファーマシューティカ エヌ．ベー． Ｍｃｌ－１の大環状阻害剤

Also Published As

Publication number Publication date
AU2021222332A1 (en) 2022-10-20
BR112022016444A2 (pt) 2022-10-18
WO2021165370A1 (en) 2021-08-26
KR20220143906A (ko) 2022-10-25
CA3168355A1 (en) 2021-08-26
CN115151551B (zh) 2024-10-25
JP2023514364A (ja) 2023-04-05
US20230130109A1 (en) 2023-04-27
EP4107161A1 (en) 2022-12-28
CN115151551A (zh) 2022-10-04

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