MX2022010406A - Sistemas, métodos y composiciones novedosas para la glucosilación de compuestos cannabinoides. - Google Patents

Sistemas, métodos y composiciones novedosas para la glucosilación de compuestos cannabinoides.

Info

Publication number
MX2022010406A
MX2022010406A MX2022010406A MX2022010406A MX2022010406A MX 2022010406 A MX2022010406 A MX 2022010406A MX 2022010406 A MX2022010406 A MX 2022010406A MX 2022010406 A MX2022010406 A MX 2022010406A MX 2022010406 A MX2022010406 A MX 2022010406A
Authority
MX
Mexico
Prior art keywords
glycosylation
compositions
methods
cannabinoid compounds
novel systems
Prior art date
Application number
MX2022010406A
Other languages
English (en)
Inventor
Timothy Travers
Erick Lebrun
Original Assignee
Trait Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trait Biosciences Inc filed Critical Trait Biosciences Inc
Publication of MX2022010406A publication Critical patent/MX2022010406A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01035—Phenol beta-glucosyltransferase (2.4.1.35)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere generalmente a la identificación de enzimas UDP glucosiltransferasas novedosas que tienen actividad específica hacia compuestos cannabinoides. La presente invención además se refiere generalmente al uso de enzimas UGT novedosas que tienen actividad específica hacia compuestos cannabinoides para generar compuestos glucósidos cannabinoides hidrosolubles.
MX2022010406A 2020-02-28 2021-02-26 Sistemas, métodos y composiciones novedosas para la glucosilación de compuestos cannabinoides. MX2022010406A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062983019P 2020-02-28 2020-02-28
PCT/US2021/020040 WO2021174092A1 (en) 2020-02-28 2021-02-26 Novel systems, methods, and compositions for the glycosylation of cannabinoid compounds

Publications (1)

Publication Number Publication Date
MX2022010406A true MX2022010406A (es) 2022-11-09

Family

ID=77490354

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010406A MX2022010406A (es) 2020-02-28 2021-02-26 Sistemas, métodos y composiciones novedosas para la glucosilación de compuestos cannabinoides.

Country Status (6)

Country Link
US (2) US12378586B2 (es)
EP (1) EP4110906A4 (es)
AU (1) AU2021228218A1 (es)
CA (1) CA3168127A1 (es)
MX (1) MX2022010406A (es)
WO (1) WO2021174092A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3063186A1 (en) 2017-05-09 2018-11-15 Vitality Biopharma, Inc. Antimicrobial compositions comprising cannabinoids and methods of using the same
EP3877519B1 (en) 2018-11-09 2026-03-11 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
WO2022126028A1 (en) * 2020-12-11 2022-06-16 Graphium Biosciences, Inc. Continuous enzymatic perfusion reactor system
US20250207145A1 (en) * 2022-04-13 2025-06-26 Yeda Research And Development Co. Ltd. Uridine diphosphate-glycosyltransferase and a transgenic cell, tissue, and organism comprising same
EP4728060A1 (en) * 2023-06-14 2026-04-22 Trait Biosciences, Inc. Improved synthesis of cannabinoid glycoside compounds
AR133824A1 (es) * 2023-09-15 2025-11-05 Icosavax Inc Proteínas virales y nanoestructuras y usos de estas
CN118216423A (zh) * 2024-05-22 2024-06-21 昆药集团股份有限公司 一种工业大麻的选育及栽培方法
CN120738266B (zh) * 2025-08-15 2025-11-21 西部(重庆)科学城种质创制大科学中心 CsPGT1基因在提高柑橘黄酮化合物含量中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0410866D0 (en) 2004-05-14 2004-06-16 Chiron Srl Haemophilius influenzae
AU2006220772A1 (en) * 2005-03-04 2006-09-14 Verenium Corporation Nucleic acids and proteins and methods for making and using them
CA3056929A1 (en) * 2017-03-24 2018-09-27 Trait Biosciences, Inc. High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems
CA3130763A1 (en) * 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors

Also Published As

Publication number Publication date
US12378586B2 (en) 2025-08-05
EP4110906A1 (en) 2023-01-04
EP4110906A4 (en) 2024-03-20
CA3168127A1 (en) 2021-09-02
AU2021228218A1 (en) 2022-09-01
WO2021174092A1 (en) 2021-09-02
US20250361537A1 (en) 2025-11-27
US20230212625A1 (en) 2023-07-06

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