MX2024007768A - Combinacion de un antagonista de adrenoreceptor a2 subtipo c (alfa-2c) con un inhibidor de recaptacion de norepinefrina para el tratamiento de apnea del sue?o. - Google Patents

Combinacion de un antagonista de adrenoreceptor a2 subtipo c (alfa-2c) con un inhibidor de recaptacion de norepinefrina para el tratamiento de apnea del sue?o.

Info

Publication number
MX2024007768A
MX2024007768A MX2024007768A MX2024007768A MX2024007768A MX 2024007768 A MX2024007768 A MX 2024007768A MX 2024007768 A MX2024007768 A MX 2024007768A MX 2024007768 A MX2024007768 A MX 2024007768A MX 2024007768 A MX2024007768 A MX 2024007768A
Authority
MX
Mexico
Prior art keywords
alpha
treatment
combination
reuptake inhibitor
antagonist
Prior art date
Application number
MX2024007768A
Other languages
English (en)
Inventor
Michael Hahn
Martina Delbeck
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2024007768A publication Critical patent/MX2024007768A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a una combinación de un inhibidor de recaptación de noradrenalina, y antagonistas de adrenoreceptor a2 subtipo C (alfa-2C), en particular carboxamidas heterocíclicas sustituidas de la fórmula (I) para el tratamiento y/o profilaxis de trastornos respiratorios relacionados con el sueño, preferentemente apneas obstructiva y central del sueño y ronquidos.
MX2024007768A 2021-12-22 2022-12-20 Combinacion de un antagonista de adrenoreceptor a2 subtipo c (alfa-2c) con un inhibidor de recaptacion de norepinefrina para el tratamiento de apnea del sue?o. MX2024007768A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21216872 2021-12-22
PCT/EP2022/086965 WO2023118123A1 (en) 2021-12-22 2022-12-20 Combination of an α2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea

Publications (1)

Publication Number Publication Date
MX2024007768A true MX2024007768A (es) 2024-07-01

Family

ID=80225456

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024007768A MX2024007768A (es) 2021-12-22 2022-12-20 Combinacion de un antagonista de adrenoreceptor a2 subtipo c (alfa-2c) con un inhibidor de recaptacion de norepinefrina para el tratamiento de apnea del sue?o.

Country Status (11)

Country Link
US (1) US20250049779A1 (es)
EP (1) EP4452242A1 (es)
JP (1) JP2025500344A (es)
KR (1) KR20240124995A (es)
CN (1) CN118475347A (es)
AU (1) AU2022418121A1 (es)
CA (1) CA3256789A1 (es)
IL (1) IL313646A (es)
MX (1) MX2024007768A (es)
TW (1) TW202342033A (es)
WO (1) WO2023118123A1 (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966781A (en) 1970-12-17 1976-06-29 Merck Sharp & Dohme (I.A.) Corporation Deuteration of functional group-containing hydrocarbons
WO2003082866A1 (en) 2002-04-03 2003-10-09 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
US20180235934A1 (en) 2015-08-18 2018-08-23 Massachusetts Institute Of Technology Noradrenergic drug treatment of obstructive sleep apnea
CN119185558A (zh) 2017-04-28 2024-12-27 布里格姆妇女医院 用于治疗睡眠呼吸暂停的方法和组合物
CN111670050A (zh) 2018-01-30 2020-09-15 爱普宁公司(特拉华) 用于治疗睡眠呼吸暂停的方法和组合物
CA3117766A1 (en) * 2018-10-31 2020-05-07 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
CN120025328A (zh) 2019-11-06 2025-05-23 拜耳公司 肾上腺素能受体adrac2拮抗剂

Also Published As

Publication number Publication date
EP4452242A1 (en) 2024-10-30
WO2023118123A1 (en) 2023-06-29
IL313646A (en) 2024-08-01
KR20240124995A (ko) 2024-08-19
CN118475347A (zh) 2024-08-09
TW202342033A (zh) 2023-11-01
AU2022418121A1 (en) 2024-07-04
CA3256789A1 (en) 2023-06-29
JP2025500344A (ja) 2025-01-09
US20250049779A1 (en) 2025-02-13

Similar Documents

Publication Publication Date Title
PH12019502427A1 (en) Methods and compositions for treating sleep apnea
CR10342A (es) INHIBIDORES DE LOS CANALES DE IONES TASK-1 y TASK-3
MX2021003428A (es) Antagonistas del receptor adrenérgico a2 subtipo c (alfa-2c) para el tratamiento de la apnea del sueño.
GEAP202115256A (en) Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
MX2025004365A (es) Metodos y composiciones para el tratamiento de la apnea del sue?o
TN2020000021A1 (en) Substituted diazahetero-bicyclic compounds and their use
NZ582284A (en) Carbamoyl-cyclohexanes for treating acute mania
MX2019007378A (es) Formas de administracion farmaceutica que contienen inhibidores de canales task-1 y task-3 y su uso para el tratamiento de trastornos respiratorios.
PH12019501458A1 (en) Pharmaceutical dosage forms containing task-1 and task-3 channel inhibitors, and the use of same in breathing disorder therapy
JOP20230005A1 (ar) توليفة من مضاد مستقبلة ألفا 2 الأدرينالية من النمط الثانوي سي (ألفا-2سي) مع حاصرة قناة task1/3 لعلاج انقطاع النفس أثناء النوم
SA521422114B1 (ar) عملية لإنتاج أشكال جرعة صيدلانية تحتوي على مثبطات قناة واستخدامها في علاج اضطراب التنفس task-1 و task-3،
MX2024007764A (es) Combinacion de un bloqueante de canales task1/3 con un inhibidor de la recaptacion de norepinefrina para el tratamiento de la apnea del sue?o.
MX2021005842A (es) Antagonistas de los adrenoreceptores a2 subtipo c (alfa-2c) para el tratamiento de la apnea del sueño.
MX2024008522A (es) Derivados de 2,3-dihidrobenzo[b][1,4]dioxin-2-ilmetil)piperazin-1- ilo para el tratamiento de la apnea del sue?o.
MX2024008523A (es) Antagonistas del adrenoceptor a2 subtipo c para el tratamiento de la apnea del sue?o.
MX2024007767A (es) Combinacion de un antagonista del adrenoceptor a2 subtipo c (alfa-2c) con un antagonista del receptor muscarinico para el tratamiento de la apnea del sue?o.
IL313646A (en) Combination of an α2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea
Spencer et al. Does weight loss affect the apnea/hypopnea index?
Dotan et al. Sleep Induced Dissociation Between Neural Drive And Mechanical Effect Of The Genioglossus In Obstructive Sleep Apnea