MX2024012014A - Formas de sales de mesembrina - Google Patents

Formas de sales de mesembrina

Info

Publication number
MX2024012014A
MX2024012014A MX2024012014A MX2024012014A MX2024012014A MX 2024012014 A MX2024012014 A MX 2024012014A MX 2024012014 A MX2024012014 A MX 2024012014A MX 2024012014 A MX2024012014 A MX 2024012014A MX 2024012014 A MX2024012014 A MX 2024012014A
Authority
MX
Mexico
Prior art keywords
mesembrine
sub
salts
forms
besylate
Prior art date
Application number
MX2024012014A
Other languages
English (en)
Inventor
Ryan Joseph Protzko
Royston Anthony Gray
Original Assignee
Kanna Health Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanna Health Ltd filed Critical Kanna Health Ltd
Publication of MX2024012014A publication Critical patent/MX2024012014A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a las formas de sales de besilato, fosfato, tartrato, fumarato y succinato de mesembrina, también conocida como 3a-(3,4-dimetoxifenil)- octahidro-1-metil-6H-indol-6-ona. La mesembrina tiene la fórmula química C17H23NO3. La invención se refiere además a las composiciones farmacéuticas que comprenden dichas sales, y a su uso médico. En una modalidad, la sal es besilato de mesembrina en forma cristalina. También se describe un proceso general para la preparación de una sal de mesembrina.
MX2024012014A 2022-04-01 2024-09-27 Formas de sales de mesembrina MX2024012014A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2204778.1A GB2619907A (en) 2022-04-01 2022-04-01 Novel crystalline salt forms of mesembrine
PCT/GB2023/050874 WO2023187421A1 (en) 2022-04-01 2023-03-31 Salt forms of mesembrine

Publications (1)

Publication Number Publication Date
MX2024012014A true MX2024012014A (es) 2025-01-09

Family

ID=81581466

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024012014A MX2024012014A (es) 2022-04-01 2024-09-27 Formas de sales de mesembrina

Country Status (10)

Country Link
US (2) US11970446B2 (es)
EP (1) EP4504698A1 (es)
JP (1) JP2025511217A (es)
KR (1) KR20250007527A (es)
CN (1) CN119233966A (es)
AU (1) AU2023244585A1 (es)
CA (1) CA3246925A1 (es)
GB (1) GB2619907A (es)
MX (1) MX2024012014A (es)
WO (1) WO2023187421A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250051277A1 (en) 2021-10-29 2025-02-13 Sensorium Therapeutics, Inc. Delivery of therapeutic alkaloid compounds
GB2619907A (en) 2022-04-01 2023-12-27 Kanna Health Ltd Novel crystalline salt forms of mesembrine
WO2024015559A2 (en) * 2022-07-15 2024-01-18 Sensorium Therapeutics, Inc. Solid forms of mesembrine and therapeutic uses thereof
GB2623122A (en) * 2022-10-07 2024-04-10 Kanna Health Ltd Preparation of mesembrine

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Also Published As

Publication number Publication date
US20240409512A1 (en) 2024-12-12
EP4504698A1 (en) 2025-02-12
AU2023244585A1 (en) 2024-11-07
GB202204778D0 (en) 2022-05-18
CN119233966A (zh) 2024-12-31
KR20250007527A (ko) 2025-01-14
WO2023187421A1 (en) 2023-10-05
US11970446B2 (en) 2024-04-30
CA3246925A1 (en) 2023-10-05
JP2025511217A (ja) 2025-04-15
US12595231B2 (en) 2026-04-07
US20230312469A1 (en) 2023-10-05
GB2619907A (en) 2023-12-27

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