MX344465B - Sistema de separacion de celulas a traves de membrana por presion alternamente neumatica. - Google Patents

Sistema de separacion de celulas a traves de membrana por presion alternamente neumatica.

Info

Publication number
MX344465B
MX344465B MX2013009030A MX2013009030A MX344465B MX 344465 B MX344465 B MX 344465B MX 2013009030 A MX2013009030 A MX 2013009030A MX 2013009030 A MX2013009030 A MX 2013009030A MX 344465 B MX344465 B MX 344465B
Authority
MX
Mexico
Prior art keywords
separation system
cell separation
pressure membrane
membrane cell
alternating pressure
Prior art date
Application number
MX2013009030A
Other languages
English (en)
Other versions
MX2013009030A (es
Inventor
Pralong Alain
Ulrich Dellenbach Hans
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Publication of MX2013009030A publication Critical patent/MX2013009030A/es
Publication of MX344465B publication Critical patent/MX344465B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/12—Apparatus for enzymology or microbiology with sterilisation, filtration or dialysis means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/20—Accessories; Auxiliary operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/58—Parts of membrane modules specifically adapted for single use
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/04—Backflushing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La invención provee un sistema de filtración novedoso que puede ser referido como separador de células alternante neumático (PACS), componentes útiles del mismo en forma de ensambles o kits de partes que se pueden usar para construir el sistema, y el uso del sistema para filtrar fluidos, por ejemplo en sistemas de perfusión de cultivo de células que comprenden una cámara que contiene filtro (8), una cámara de expansión (17) y un controlador de flujo de gas (28).
MX2013009030A 2011-02-10 2012-02-07 Sistema de separacion de celulas a traves de membrana por presion alternamente neumatica. MX344465B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161463095P 2011-02-10 2011-02-10
EP11153995 2011-02-10
EP11183676 2011-10-03
US201161627812P 2011-10-18 2011-10-18
PCT/EP2012/052031 WO2012107436A1 (en) 2011-02-10 2012-02-07 Pneumatic alternating pressure membrane cell separation system

Publications (2)

Publication Number Publication Date
MX2013009030A MX2013009030A (es) 2013-09-06
MX344465B true MX344465B (es) 2016-12-14

Family

ID=45569654

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013009030A MX344465B (es) 2011-02-10 2012-02-07 Sistema de separacion de celulas a traves de membrana por presion alternamente neumatica.

Country Status (17)

Country Link
US (2) US8845902B2 (es)
EP (1) EP2673072B1 (es)
JP (1) JP5893051B2 (es)
KR (1) KR101890000B1 (es)
CN (1) CN103347595B (es)
AU (1) AU2012215514B2 (es)
BR (1) BR112013019325B1 (es)
CA (1) CA2824907C (es)
DK (1) DK2673072T3 (es)
EA (1) EA023614B1 (es)
ES (1) ES2529429T3 (es)
IL (1) IL227833A (es)
MX (1) MX344465B (es)
PL (1) PL2673072T3 (es)
SG (1) SG192611A1 (es)
WO (1) WO2012107436A1 (es)
ZA (1) ZA201306752B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8845902B2 (en) 2011-02-10 2014-09-30 Crucell Holland B.V. Pneumatic alternating pressure membrane cell separation system
PT3152317T (pt) * 2014-06-04 2019-04-18 Amgen Inc Métodos de colheita de culturas de células de mamíferos
EP4166224B1 (en) * 2015-08-20 2024-07-10 Cytiva Sweden AB Improved method for enhancing filtration yields in tangential flow filtration system
CN106282001A (zh) * 2016-10-09 2017-01-04 陈静 一种高通量快速捕获提纯循环肿瘤细胞的设备及方法
US10611823B2 (en) 2016-12-14 2020-04-07 Hanssen Biotech, Inc CD137 binding fibronectin type III domains
CN107058086B (zh) * 2017-05-26 2020-07-03 奥凯（苏州）生物技术有限公司 一种防止细胞堵塞培养器的方法及系统
US10774297B2 (en) * 2017-08-03 2020-09-15 Repligen Corporation Method of actuation of an alternating tangential flow diaphragm pump
CN111565823B (zh) * 2018-01-12 2023-03-31 富默乐有限公司 切向流过滤tff系统和包括集成泵装置的一次性tff单元
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
CN114761534B (zh) 2019-11-27 2025-09-16 康宁股份有限公司 固定床细胞培养和收获系统及其使用方法
KR102142479B1 (ko) * 2020-01-09 2020-08-07 주식회사 엠디뮨 세포 압출기 및 세포 압출방법
US20230120489A1 (en) * 2020-03-06 2023-04-20 Yukuan Shang Perfusion module and perfusion culture system
CN111530285A (zh) * 2020-05-26 2020-08-14 英诺维尔智能科技（苏州）有限公司 一种适用于生物制品规模化生产的过滤收集装置
US20230313117A1 (en) * 2020-07-20 2023-10-05 Janssen Biotech, Inc. Fluid filtration system
WO2022026503A1 (en) * 2020-07-30 2022-02-03 Corning Incorporated Cell culture autofill system
CN115747055A (zh) * 2022-11-16 2023-03-07 四川至善唯新生物科技有限公司 一种细胞灌流培养的方法
CN116463203A (zh) * 2023-04-12 2023-07-21 楚天思为康基因科技(长沙)有限公司 一种一次性细胞培养器具及细胞培养装置
CN116445257A (zh) * 2023-04-12 2023-07-18 楚天思为康基因科技(长沙)有限公司 一种一次性细胞分离器具及细胞分离装置

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4502953A (en) * 1983-09-02 1985-03-05 Plasworld, Inc. Water purifying apparatus with air check valve and filter condition indication
US4861498A (en) 1987-12-30 1989-08-29 R & L Filtration Limited Backwash system for filter-thickeners
US5234424A (en) * 1988-12-28 1993-08-10 Alza Corporation Osmotically driven syringe
US5039402A (en) * 1989-11-15 1991-08-13 Himelstein Walter D Water purifier
US5055198A (en) * 1990-03-07 1991-10-08 Shettigar U Ramakrishna Autologous blood recovery membrane system and method
AT396919B (de) * 1992-03-27 1993-12-27 Hochgatterer Josef Wasseraufbereitungsgerät
US5254243A (en) * 1992-06-22 1993-10-19 Whirlpool Corporation Water conditioning system and an electronic control therefor
US5256279A (en) * 1992-07-02 1993-10-26 Carr-Griff, Inc. Liquid storage system with unpressurized reservoir engagable with level sensors
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5911884A (en) * 1996-12-02 1999-06-15 Entre Pure Industries Contamination proof purified water dispenser and method of using same
US6945257B2 (en) * 1997-06-23 2005-09-20 Princeton Trade & Technology Method for cleaning hollow tubing and fibers
US6093312A (en) * 1998-01-22 2000-07-25 Entre Pure, Inc. Ice dispenser with an air-cooled bin
US7288195B2 (en) * 1999-05-28 2007-10-30 Bio/Data Corporation Method and apparatus for directly sampling a fluid for microfiltration
US6544424B1 (en) * 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
AUPR692401A0 (en) 2001-08-09 2001-08-30 U.S. Filter Wastewater Group, Inc. Method of cleaning membrane modules
EP1424119A3 (en) 2002-11-29 2004-06-16 Taisei Kogyo Co., Ltd. Filter apparatus with cleaning means
US7910074B2 (en) * 2005-10-13 2011-03-22 Beckman Coulter, Inc. System and method for continuously transferring and processing liquids
DE202005018578U1 (de) 2005-11-25 2007-04-05 Kaifel, Rainer Handpumpe in Kombination mit Membranmodulen mit schlauchförmigen Membranen
SI2041259T1 (sl) 2006-07-14 2016-04-29 Dpx Holdings B.V. Izboljšan postopek kultiviranja celic
CA2737160A1 (en) * 2008-09-24 2010-04-01 Jerry Shevitz Screen filter module for alternating flow filtration
CN102203242B (zh) 2008-11-03 2013-06-12 克鲁塞尔荷兰公司 产生腺病毒载体的方法
WO2012026978A2 (en) * 2010-08-25 2012-03-01 Jerry Shevitz Fluid filtration systems
US8845902B2 (en) 2011-02-10 2014-09-30 Crucell Holland B.V. Pneumatic alternating pressure membrane cell separation system

Also Published As

Publication number Publication date
SG192611A1 (en) 2013-09-30
US20130319944A1 (en) 2013-12-05
EA201391149A1 (ru) 2013-12-30
KR101890000B1 (ko) 2018-08-20
CN103347595A (zh) 2013-10-09
AU2012215514A1 (en) 2013-08-29
MX2013009030A (es) 2013-09-06
EP2673072B1 (en) 2014-11-19
NZ614364A (en) 2015-07-31
CN103347595B (zh) 2016-01-20
IL227833A (en) 2017-02-28
KR20140004150A (ko) 2014-01-10
AU2012215514B2 (en) 2017-04-20
ZA201306752B (en) 2014-05-28
BR112013019325A2 (en) 2018-07-17
JP2014514129A (ja) 2014-06-19
EP2673072A1 (en) 2013-12-18
CA2824907A1 (en) 2012-08-16
EA023614B1 (ru) 2016-06-30
ES2529429T3 (es) 2015-02-20
CA2824907C (en) 2020-07-07
BR112013019325B1 (pt) 2020-12-15
JP5893051B2 (ja) 2016-03-23
IL227833A0 (en) 2013-09-30
PL2673072T3 (pl) 2015-04-30
DK2673072T3 (en) 2015-02-16
US20140342446A1 (en) 2014-11-20
US8845902B2 (en) 2014-09-30
WO2012107436A1 (en) 2012-08-16

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