MX347319B - Filtracion de virus de medio de cultivo celular. - Google Patents
Filtracion de virus de medio de cultivo celular.Info
- Publication number
- MX347319B MX347319B MX2014015950A MX2014015950A MX347319B MX 347319 B MX347319 B MX 347319B MX 2014015950 A MX2014015950 A MX 2014015950A MX 2014015950 A MX2014015950 A MX 2014015950A MX 347319 B MX347319 B MX 347319B
- Authority
- MX
- Mexico
- Prior art keywords
- cell culture
- culture medium
- filtration
- present
- preparation
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
- A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
- A61L2/022—Filtration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/26—Conditioning fluids entering or exiting the reaction vessel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/02—Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2103/00—Materials or objects being the target of disinfection or sterilisation
- A61L2103/05—Living organisms or biological materials
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Filtering Materials (AREA)
Abstract
La presente invención se refiere a un método para eliminar un contaminante viral de una preparación, siendo un medio de cultivo celular o al menos un componente de un medio de cultivo celular. El método comprende someter la preparación a una filtración durante al menos aproximadamente 24 horas a través de un filtro de virus que tiene un tamaño de poro efectivo de aproximadamente 75 nm máximo. Además, la presente invención se refiere al uso de un filtro de virus en una filtración de al menos aproximadamente 24 horas, en donde el filtro de virus tiene un tamaño de poro efectivo de aproximadamente 75 nm máximo para la eliminación de un contaminante viral de una preparación, siendo un medio de cultivo celular o al menos un componente de un medio de cultivo celular. En algunas modalidades la filtración de acuerdo con la presente invención opera en una capacidad volumétrica de al menos aproximadamente 2000 L/m2. Además, la presente invención se refiere al uso de una preparación, siendo un medio de cultivo celular o al menos un componente de un medio de cultivo celular que se puede obtener de acuerdo con el método de la presente invención para un cultivo celular; preparaciones farmacéuticas, de diagnóstico y/o cosméticas así como en preparaciones alimenticias.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261662814P | 2012-06-21 | 2012-06-21 | |
| PCT/US2013/045663 WO2013192009A1 (en) | 2012-06-21 | 2013-06-13 | Virus filtration of cell culture media |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014015950A MX2014015950A (es) | 2015-07-17 |
| MX347319B true MX347319B (es) | 2017-04-21 |
Family
ID=48672845
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014015950A MX347319B (es) | 2012-06-21 | 2013-06-13 | Filtracion de virus de medio de cultivo celular. |
| MX2017005169A MX386767B (es) | 2012-06-21 | 2013-06-13 | Filtración de virus de medio de cultivo celular. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017005169A MX386767B (es) | 2012-06-21 | 2013-06-13 | Filtración de virus de medio de cultivo celular. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9670456B2 (es) |
| EP (2) | EP2732020B1 (es) |
| JP (3) | JP6220392B2 (es) |
| KR (2) | KR20190092618A (es) |
| CN (2) | CN104640969A (es) |
| AR (1) | AR092847A1 (es) |
| AU (2) | AU2013277532B2 (es) |
| BR (1) | BR112014031842B1 (es) |
| CA (1) | CA2876473C (es) |
| CO (1) | CO7151484A2 (es) |
| DK (2) | DK2732020T3 (es) |
| EA (2) | EA201990887A1 (es) |
| ES (2) | ES2601429T3 (es) |
| HR (1) | HRP20161435T1 (es) |
| HU (1) | HUE031601T2 (es) |
| IL (2) | IL236073B (es) |
| IN (1) | IN2014DN10441A (es) |
| MX (2) | MX347319B (es) |
| MY (2) | MY195362A (es) |
| NZ (1) | NZ629083A (es) |
| PL (2) | PL3103861T3 (es) |
| PT (2) | PT2732020T (es) |
| SG (2) | SG11201408490PA (es) |
| SI (1) | SI2732020T1 (es) |
| TW (2) | TWI698522B (es) |
| WO (1) | WO2013192009A1 (es) |
| ZA (1) | ZA201409253B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3103861T3 (pl) * | 2012-06-21 | 2021-03-22 | Takeda Pharmaceutical Company Limited | Filtracja wirusowa pożywek do hodowli komórkowej |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| SG10201507931QA (en) * | 2014-12-22 | 2016-07-28 | Emd Millipore Corp | Removal of microorganisms from cell culture media |
| US20180072769A1 (en) * | 2015-03-23 | 2018-03-15 | Alexion Pharmaceuticals, Inc. | Virus filtration |
| EP3015542A1 (de) * | 2015-05-07 | 2016-05-04 | Bayer Technology Services GmbH | Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes |
| TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| EP3443064A1 (en) * | 2016-04-15 | 2019-02-20 | Boehringer Ingelheim International GmbH | Cell retention device and method |
| CN110225790A (zh) * | 2016-12-09 | 2019-09-10 | 龙沙有限公司 | 减少药物中病毒滴度的方法 |
| KR102659791B1 (ko) * | 2017-07-06 | 2024-04-23 | 리제너론 파마슈티칼스 인코포레이티드 | 당단백질을 만들기 위한 세포 배양 과정 |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| CN113784779A (zh) | 2019-03-11 | 2021-12-10 | 建新公司 | 切向病毒过滤 |
| TW202540143A (zh) * | 2019-04-03 | 2025-10-16 | 美商健臻公司 | 重組蛋白的連續式生產 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| US20230181796A1 (en) * | 2020-05-14 | 2023-06-15 | North Carolina State University | Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues |
| WO2022072899A1 (en) * | 2020-10-02 | 2022-04-07 | Regeneron Pharmaceuticals, Inc. | Continuous virus retentive filtration |
| WO2025019797A2 (en) * | 2023-07-19 | 2025-01-23 | Hatchless Inc. | System and method for low-cost sterilization of liquids |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0422874A (ja) * | 1990-05-16 | 1992-01-27 | Matsushita Electric Ind Co Ltd | 波形表示装置 |
| GB2352652A (en) * | 1999-08-06 | 2001-02-07 | Fsm Technologies Ltd | Pre-treating hollow fibre membranes for micro-organism detection |
| US6485686B1 (en) * | 1999-09-17 | 2002-11-26 | The United States Of America As Represented By The Secretary Of The Army | Method and apparatus for counting submicron sized particles |
| WO2001040448A1 (en) | 1999-12-02 | 2001-06-07 | The General Hospital Corporation | Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon |
| US6485688B1 (en) | 2000-04-24 | 2002-11-26 | General Electric Company | On-line sparging sampling and monitoring systems and methods |
| US6835311B2 (en) * | 2002-01-31 | 2004-12-28 | Koslow Technologies Corporation | Microporous filter media, filtration systems containing same, and methods of making and using |
| US6630016B2 (en) * | 2002-01-31 | 2003-10-07 | Koslow Technologies Corp. | Microporous filter media, filtration systems containing same, and methods of making and using |
| ES2214967B1 (es) | 2003-03-06 | 2005-06-16 | Probitas Pharma, S.A | Procedimiento para la eliminacion de virus en soluciones de fibrinogeno y fibrinogeno obtenido por dicho procedimiento. |
| ES2507091T3 (es) | 2003-12-01 | 2014-10-14 | Novo Nordisk Health Care Ag | Nanofiltración de soluciones del factor VII para eliminar virus |
| DE102005047301B4 (de) * | 2005-09-30 | 2009-04-16 | Sartorius Stedim Biotech Gmbh | Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen |
| US20070084788A1 (en) * | 2005-10-14 | 2007-04-19 | Millipore Corporation | Ultrafiltration membranes and methods of making and use of ultrafiltration membranes |
| US8309029B1 (en) * | 2009-03-26 | 2012-11-13 | The United States Of America As Represented By The Secretary Of The Army | Virus and particulate separation from solution |
| US8945895B2 (en) * | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| BR112012003802B1 (pt) * | 2009-08-20 | 2022-10-25 | Takeda Pharmaceutical Company Limited | Método para remover um vírus sem envelope lipídico de uma solução |
| PL3103861T3 (pl) * | 2012-06-21 | 2021-03-22 | Takeda Pharmaceutical Company Limited | Filtracja wirusowa pożywek do hodowli komórkowej |
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2013
- 2013-06-13 PL PL16181886.9T patent/PL3103861T3/pl unknown
- 2013-06-13 JP JP2015518459A patent/JP6220392B2/ja active Active
- 2013-06-13 HR HRP20161435TT patent/HRP20161435T1/hr unknown
- 2013-06-13 CA CA2876473A patent/CA2876473C/en active Active
- 2013-06-13 NZ NZ629083A patent/NZ629083A/en unknown
- 2013-06-13 HU HUE13731015A patent/HUE031601T2/hu unknown
- 2013-06-13 DK DK13731015.7T patent/DK2732020T3/en active
- 2013-06-13 PL PL13731015T patent/PL2732020T3/pl unknown
- 2013-06-13 PT PT137310157T patent/PT2732020T/pt unknown
- 2013-06-13 MY MYPI2018000283A patent/MY195362A/en unknown
- 2013-06-13 EA EA201990887A patent/EA201990887A1/ru unknown
- 2013-06-13 MY MYPI2014003498A patent/MY173835A/en unknown
- 2013-06-13 DK DK16181886.9T patent/DK3103861T3/da active
- 2013-06-13 EP EP13731015.7A patent/EP2732020B1/en active Active
- 2013-06-13 CN CN201380032998.7A patent/CN104640969A/zh active Pending
- 2013-06-13 CN CN201810569534.4A patent/CN108795724A/zh active Pending
- 2013-06-13 PT PT161818869T patent/PT3103861T/pt unknown
- 2013-06-13 MX MX2014015950A patent/MX347319B/es active IP Right Grant
- 2013-06-13 KR KR1020197022413A patent/KR20190092618A/ko not_active Ceased
- 2013-06-13 KR KR1020157001269A patent/KR102008048B1/ko active Active
- 2013-06-13 SG SG11201408490PA patent/SG11201408490PA/en unknown
- 2013-06-13 MX MX2017005169A patent/MX386767B/es unknown
- 2013-06-13 AU AU2013277532A patent/AU2013277532B2/en active Active
- 2013-06-13 WO PCT/US2013/045663 patent/WO2013192009A1/en not_active Ceased
- 2013-06-13 BR BR112014031842-5A patent/BR112014031842B1/pt not_active IP Right Cessation
- 2013-06-13 ES ES13731015.7T patent/ES2601429T3/es active Active
- 2013-06-13 IN IN10441DEN2014 patent/IN2014DN10441A/en unknown
- 2013-06-13 EP EP16181886.9A patent/EP3103861B1/en active Active
- 2013-06-13 EA EA201590059A patent/EA033006B1/ru not_active IP Right Cessation
- 2013-06-13 SI SI201330369A patent/SI2732020T1/sl unknown
- 2013-06-13 SG SG10201701721TA patent/SG10201701721TA/en unknown
- 2013-06-13 ES ES16181886T patent/ES2829968T3/es active Active
- 2013-06-19 AR ARP130102198A patent/AR092847A1/es active IP Right Grant
- 2013-06-19 TW TW106136343A patent/TWI698522B/zh active
- 2013-06-19 TW TW102121710A patent/TWI609962B/zh active
- 2013-06-19 US US13/921,417 patent/US9670456B2/en active Active
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2014
- 2014-12-04 IL IL236073A patent/IL236073B/en active IP Right Grant
- 2014-12-15 ZA ZA2014/09253A patent/ZA201409253B/en unknown
- 2014-12-17 CO CO14277524A patent/CO7151484A2/es unknown
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2017
- 2017-03-27 US US15/470,064 patent/US20170260498A1/en not_active Abandoned
- 2017-07-13 JP JP2017137031A patent/JP6557706B2/ja not_active Expired - Fee Related
- 2017-09-12 AU AU2017228547A patent/AU2017228547B2/en active Active
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2018
- 2018-11-14 JP JP2018213613A patent/JP2019022526A/ja not_active Withdrawn
- 2018-12-04 IL IL263479A patent/IL263479B/en active IP Right Grant
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2020
- 2020-03-12 US US16/816,641 patent/US11421202B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: BAXALTA INCORPORATED |
|
| FG | Grant or registration |