MX355409B - Proceso para la preparacion de n- [5- (3,5-difluoro-bencil) -1h-indazol-3-il] -4- (4-metil-piperazin-1-il) -2- (tetrahidro-piran-4-ilamino) -benzamida. - Google Patents

Proceso para la preparacion de n- [5- (3,5-difluoro-bencil) -1h-indazol-3-il] -4- (4-metil-piperazin-1-il) -2- (tetrahidro-piran-4-ilamino) -benzamida.

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Publication number
MX355409B
MX355409B MX2014013924A MX2014013924A MX355409B MX 355409 B MX355409 B MX 355409B MX 2014013924 A MX2014013924 A MX 2014013924A MX 2014013924 A MX2014013924 A MX 2014013924A MX 355409 B MX355409 B MX 355409B
Authority
MX
Mexico
Prior art keywords
piperazin
benzamide
pyran
difluoro
tetrahydro
Prior art date
Application number
MX2014013924A
Other languages
English (en)
Other versions
MX2014013924A (es
Inventor
Alvaro Barbugian Natale
Forino Romualdo
Fumagalli Tiziano
Orsini Paolo
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of MX2014013924A publication Critical patent/MX2014013924A/es
Publication of MX355409B publication Critical patent/MX355409B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de N-[5-(3,5-difluoro-bencil)-1H-indazol-3-il]-4-(4-metil-piperazi n-1-il)-2-(tetrahidro-piran-4-ilamino) -benzamida. Las nuevas formas sólidas de este compuesto, su utilidad en el tratamiento de enfermedades provocadas por la mala regulación de la actividad de proteína quinasa y composiciones farmacéuticas que las contienen son también el objeto de la presente invención.
MX2014013924A 2012-05-23 2013-05-22 Proceso para la preparacion de n- [5- (3,5-difluoro-bencil) -1h-indazol-3-il] -4- (4-metil-piperazin-1-il) -2- (tetrahidro-piran-4-ilamino) -benzamida. MX355409B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12169139 2012-05-23
PCT/EP2013/060534 WO2013174876A1 (en) 2012-05-23 2013-05-22 Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide

Publications (2)

Publication Number Publication Date
MX2014013924A MX2014013924A (es) 2015-02-17
MX355409B true MX355409B (es) 2018-04-18

Family

ID=48470987

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013924A MX355409B (es) 2012-05-23 2013-05-22 Proceso para la preparacion de n- [5- (3,5-difluoro-bencil) -1h-indazol-3-il] -4- (4-metil-piperazin-1-il) -2- (tetrahidro-piran-4-ilamino) -benzamida.

Country Status (17)

Country Link
US (3) US9085565B2 (es)
EP (4) EP3290414B1 (es)
JP (1) JP6231556B2 (es)
KR (1) KR102151963B1 (es)
CN (2) CN104395308B (es)
AR (1) AR091138A1 (es)
AU (2) AU2013265288B2 (es)
BR (1) BR112014028841B1 (es)
CA (1) CA2873979C (es)
ES (2) ES2771100T3 (es)
IL (2) IL235761B (es)
MX (1) MX355409B (es)
NZ (2) NZ716487A (es)
PL (2) PL3333166T3 (es)
RU (1) RU2602071C2 (es)
TW (1) TWI579280B (es)
WO (1) WO2013174876A1 (es)

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Also Published As

Publication number Publication date
US9649306B2 (en) 2017-05-16
EP3290414A1 (en) 2018-03-07
KR102151963B1 (ko) 2020-09-07
CA2873979A1 (en) 2013-11-28
BR112014028841A2 (pt) 2017-06-27
AU2018201037A1 (en) 2018-03-01
PL3333166T3 (pl) 2020-09-07
IL235761B (en) 2018-07-31
KR20150016352A (ko) 2015-02-11
US20150051222A1 (en) 2015-02-19
NZ703124A (en) 2016-07-29
JP2015517551A (ja) 2015-06-22
IL260297A (en) 2018-08-30
US9085565B2 (en) 2015-07-21
ES2771100T3 (es) 2020-07-06
RU2014151565A (ru) 2016-07-20
TW201400479A (zh) 2014-01-01
WO2013174876A1 (en) 2013-11-28
AU2018201037B2 (en) 2019-07-04
EP3290414B1 (en) 2019-07-24
MX2014013924A (es) 2015-02-17
EP3333166B1 (en) 2019-11-06
AR091138A1 (es) 2015-01-14
BR112014028841B1 (pt) 2021-01-12
EP3333166A1 (en) 2018-06-13
AU2013265288A2 (en) 2015-01-29
CA2873979C (en) 2019-11-12
AU2013265288A1 (en) 2015-01-22
TWI579280B (zh) 2017-04-21
ES2751944T3 (es) 2020-04-02
NZ716487A (en) 2017-01-27
US20150274707A1 (en) 2015-10-01
PL3290414T3 (pl) 2020-01-31
US20160279125A1 (en) 2016-09-29
RU2602071C2 (ru) 2016-11-10
CN104395308B (zh) 2016-08-24
US9382235B2 (en) 2016-07-05
EP2855460A1 (en) 2015-04-08
JP6231556B2 (ja) 2017-11-15
CN106167485A (zh) 2016-11-30
HK1207077A1 (en) 2016-01-22
EP3581571A1 (en) 2019-12-18
IL235761A0 (en) 2015-02-01
CN104395308A (zh) 2015-03-04
AU2013265288B2 (en) 2017-12-21
EP2855460B1 (en) 2017-11-08

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