MX363473B - Uso de fenilbenzamidas para tratar condiciones mediadas por acuaporina. - Google Patents

Uso de fenilbenzamidas para tratar condiciones mediadas por acuaporina.

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Publication number
MX363473B
MX363473B MX2014013639A MX2014013639A MX363473B MX 363473 B MX363473 B MX 363473B MX 2014013639 A MX2014013639 A MX 2014013639A MX 2014013639 A MX2014013639 A MX 2014013639A MX 363473 B MX363473 B MX 363473B
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MX
Mexico
Prior art keywords
well
edema
aquaporin
ischemia
diseases
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Application number
MX2014013639A
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English (en)
Other versions
MX2014013639A (es
Inventor
F Pelletier Marc
William Farr George
H Hall Christopher
F Boron Walter
Robert Mcguirk Paul
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Aeromics Inc
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Publication date
Application filed by Aeromics Inc filed Critical Aeromics Inc
Publication of MX2014013639A publication Critical patent/MX2014013639A/es
Publication of MX363473B publication Critical patent/MX363473B/es

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    • C07—ORGANIC CHEMISTRY
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere al uso de inhibidores de acuaporinas selectivas, por ejemplo, de acuapori-4 o acuaporin-2, por ejemplo, ciertos compuestos de fenilbenzamida, para la profilaxis, tratamiento y control de condiciones mediadas por acuaporina, por ejemplo, enfermedades de desequilibrio de agua, por ejemplo, edema (en particular edema del cerebro y médula espinal, por ejemplo, después de trauma o accidente isquémico, así como el edema asociado con glioma, meningitis, mal agudo de montaña, ataques epilépticos, infecciones, trastornos metabólicos, hipoxia, intoxicación por agua, falla hepática, encefalopatía hepática, cetoacidosis diabética, abscesos, eclampsia, enfermedad de Creurzfelft-Jakob, lupus cerebritis, así como edema consecuente con micro-gravedad y/o exposición a radiación, así como edema consecuente con procedimientos del sistema nervioso central invasivos, por ejemplo, neurocirugía, remoción de coagulo endovascular, punción lumbar, reparación de aneurisma, o estimulación cerebral profunda, así como edema retinal), asi como hiponatremia y retención excesiva de fluido, y enfermedades tales como epilepsia, isquemia retinal y otras enfermedades el ojo asociadas con anormalidades en presión intraocular y/o hidratación de tejido, isquemia al miocardio, isquemia al miocardio/daño por reperfusión, infarto al miocardio, hipoxia al miocardio, falla cardiaca congestiva, sepsis, y neuromielitis óptica, así como migrañas, así como a ensayos novedosos para identificar inhibidores de acuaporina.
MX2014013639A 2012-05-08 2013-05-08 Uso de fenilbenzamidas para tratar condiciones mediadas por acuaporina. MX363473B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261644268P 2012-05-08 2012-05-08
US201261651778P 2012-05-25 2012-05-25
US201361799606P 2013-03-15 2013-03-15
PCT/US2013/040194 WO2013169939A2 (en) 2012-05-08 2013-05-08 New methods

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MX2014013639A MX2014013639A (es) 2015-08-20
MX363473B true MX363473B (es) 2019-03-25

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US (5) US9994514B2 (es)
EP (1) EP2846787B1 (es)
JP (2) JP6238969B2 (es)
KR (1) KR102200176B1 (es)
CN (2) CN109512805B (es)
AU (2) AU2013259526B2 (es)
BR (1) BR112014027983B1 (es)
CA (1) CA2872012C (es)
ES (1) ES2699646T3 (es)
IL (1) IL235512B (es)
MX (1) MX363473B (es)
RU (1) RU2671495C2 (es)
WO (1) WO2013169939A2 (es)

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