MX364529B - Nuevos ligandos del receptor de estrógeno. - Google Patents

Nuevos ligandos del receptor de estrógeno.

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Publication number
MX364529B
MX364529B MX2014001386A MX2014001386A MX364529B MX 364529 B MX364529 B MX 364529B MX 2014001386 A MX2014001386 A MX 2014001386A MX 2014001386 A MX2014001386 A MX 2014001386A MX 364529 B MX364529 B MX 364529B
Authority
MX
Mexico
Prior art keywords
estrogen receptor
receptor ligands
novel estrogen
novel
carbamate
Prior art date
Application number
MX2014001386A
Other languages
English (en)
Other versions
MX2014001386A (es
Inventor
Cheng Aiping
Garg Neeraj
Krüger Lars
Löfstedt Joakim
Koch Eva
Koehler Konrad
Hagberg Lars
Nöteberg Daniel
Original Assignee
Karobio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karobio Ab filed Critical Karobio Ab
Publication of MX2014001386A publication Critical patent/MX2014001386A/es
Publication of MX364529B publication Critical patent/MX364529B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

Se describen los compuestos de fórmula (I) o un éster, una amida, un carbamato o una sal farmacéuticamente aceptable de los mismos, que incluyen una sal de tal éster, tal amida o tal carbamato, en los cuales R1 a R9 tienen los significados de acuerdo con lo definido en la especificación, los cuales son útiles como ligandos del receptor de estrógeno.
MX2014001386A 2011-08-04 2012-08-02 Nuevos ligandos del receptor de estrógeno. MX364529B (es)

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GBGB1113538.1A GB201113538D0 (en) 2011-08-04 2011-08-04 Novel estrogen receptor ligands
PCT/EP2012/065134 WO2013017654A1 (en) 2011-08-04 2012-08-02 Novel estrogen receptor ligands

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016036721A1 (en) 2014-09-02 2016-03-10 The Regents Of The University Of California Estrogen receptor ligand treatment for neurodegenerative diseases
EP3294705B1 (en) 2015-05-14 2021-07-21 The Wistar Institute Of Anatomy And Biology Ebna1 inhibitors and methods using same
WO2019222470A1 (en) 2018-05-17 2019-11-21 The Wistar Institute Ebna1 inhibitor crystalline forms, and methods of preparing and using same
CN109796372B (zh) * 2019-03-13 2020-03-10 中国科学院化学研究所 一种制备多取代烯基脒的方法
EP3999488A1 (en) * 2019-07-19 2022-05-25 Adama Makhteshim Ltd. Process for the preparation of biphenylamines

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519675A (en) 1964-06-01 1970-07-07 Upjohn Co 1,2-diphenyl-3,4-dihydronaphthalenes and 2,3-diphenylindenes
CH986269A4 (es) 1969-06-27 1970-12-31
US3799943A (en) 1971-06-23 1974-03-26 Sterling Drug Inc 1,2-diphenylindoles
BE787488A (fr) 1971-08-12 1973-02-12 Ciba Geigy Nouveau procede de preparation de nouvelles pentanones polycycliques
US3878225A (en) 1973-03-01 1975-04-15 Hoechst Co American Condensed pyrroles bearing an N-phenyl substituent
US4182764A (en) 1973-10-11 1980-01-08 Merck & Co., Inc. Tetrazole derivatives of [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy(or thio)]alkanoic acids
US4056624A (en) 1976-05-14 1977-11-01 American Hoechst Corporation Method of treating dermal inflammation
DE2909754A1 (de) 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
JPS5726653A (en) 1980-05-09 1982-02-12 Ciba Geigy Ag Substituted phenyl ether
US5096919A (en) 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
DE4117512A1 (de) 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB9224517D0 (en) 1992-11-23 1993-01-13 British Tech Group Controlling plant growth
CA2174080A1 (en) 1993-10-12 1995-04-20 Paul Edward Aldrich 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
US5691376A (en) 1994-02-17 1997-11-25 American Home Products Corporation Substituted biphenyl derivatives
CA2144669A1 (en) 1994-03-29 1995-09-30 Kozo Akasaka Biphenyl derivatives
WO1995027692A1 (en) 1994-04-08 1995-10-19 Smithkline Beecham Corporation Subtituted biphenyl tnf inhibitors
DE4412983A1 (de) 1994-04-15 1995-10-19 Basf Ag Phenolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung, insbesondere in der nichtlinearen Optik
DE4426625A1 (de) 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
US5696130A (en) 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Tricyclic steroid receptor modulator compounds and methods
FR2744445B1 (fr) * 1996-02-01 1998-10-02 Roussel Uclaf Composes biphenyles nouveaux et/ou a titre de medicament, compositions pharmaceutiques les contenant, leur procede de preparation et les intermediaires de ce procede
US5998402A (en) 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
EP0839808A1 (en) 1996-10-29 1998-05-06 Novartis AG Pyrazole derivatives, processes for their preparation, and their use as herbicides
HRP20000778B1 (en) 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens
DE69912279T2 (de) 1998-06-30 2004-07-29 Eli Lilly And Co., Indianapolis 5-ht1f agonisten
GB9816575D0 (en) 1998-07-31 1998-09-30 Zeneca Ltd Novel compounds
ATE355279T1 (de) 1998-08-07 2006-03-15 Novartis Vaccines & Diagnostic Pyrazole als modulatoren des östrogenrezeptors
WO2000019994A1 (en) 1998-10-02 2000-04-13 Board Of Trustees Of The University Of Illinois Estrogen receptor ligands
US6380185B1 (en) 1999-03-04 2002-04-30 American Home Products Corporation N-substituted benzoyl indoles as estrogenic agents
EP1175419B1 (en) 1999-04-02 2003-05-28 Bristol-Myers Squibb Pharma Company Aryl sulfonyls as factor xa inhibitors
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
BR0010216A (pt) * 1999-05-04 2002-03-19 American Home Prod Derivados de tio-oxindol
EP1284260A4 (en) 2000-05-22 2004-03-31 Takeda Chemical Industries Ltd TYROSIN PHOSPHATASE INHIBITORS
WO2002074758A2 (en) 2001-03-16 2002-09-26 Abbott Laboratories Novel amines as histamine-3 receptor ligands and their therapeutic applications
JP2005500379A (ja) 2001-08-17 2005-01-06 インサイト サンディエゴ インコーポレーテッド 異脂肪血症および高コレステロール血症を治療するオキシム誘導体
US6903238B2 (en) 2001-12-13 2005-06-07 Wyeth Substituted indenones as estrogenic agents
US6774248B2 (en) 2001-12-18 2004-08-10 Wyeth Substituted 2-phenyl benzofurans as estrogenic agents
EP1456180B1 (en) 2001-12-21 2007-10-03 Vernalis (Cambridge) Limited 3-(2,4)dihydroxyphenyl-4-phenylpyrazoles and their medical use
US6835745B2 (en) 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents
WO2003066889A2 (en) 2002-02-07 2003-08-14 Axys Pharmaceuticals, Inc. Assay for acytyltransferase or deacetylase activity
US20030220377A1 (en) 2002-05-08 2003-11-27 Richard Chesworth Indole compounds and their use as estrogen agonists/antagonists
CA2509191A1 (en) 2002-12-10 2004-06-24 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
GB0229618D0 (en) 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
MXPA05008587A (es) 2003-02-14 2005-11-04 Kissei Pharmaceutical Derivados de alcohol amino, composiciones farmaceuticas que contienen los mismos, y usos de los mismos.
TWI335218B (en) 2003-02-19 2011-01-01 Panion & Bf Biotech Inc Ferric organic compounds, uses thereof and methods of making same
AU2003901647A0 (en) 2003-04-04 2003-05-01 Fujisawa Pharmaceutical Co., Ltd. Novel Condensed Furan Compounds and Pharmaceutical Use Thereof
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
EP1619180B1 (en) * 2003-04-23 2009-12-16 Japan Tobacco Inc. CaSR ANTAGONIST
US7279600B2 (en) 2003-05-02 2007-10-09 Wyeth Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents
PL1633699T3 (pl) 2003-05-16 2007-05-31 Wyeth Corp Pochodne oksymów arylo-karbaldehydów i ich zastosowanie jako środków estrogennych
US7250440B2 (en) 2003-08-12 2007-07-31 Wyeth (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
US20070088067A1 (en) 2003-09-05 2007-04-19 Tidwell Richards R Novel amidine compounds for treating microbial infections
PL1696920T3 (pl) 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
ITMI20040874A1 (it) 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici ed azaindolici con azione antitumorale
EP1771169A1 (en) 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Methods for treating hepatitis c
JP2008525502A (ja) 2004-12-23 2008-07-17 デシファラ ファーマスーティカルズ， エルエルシー 抗炎症薬
AU2005323165A1 (en) 2004-12-31 2006-07-13 Aventis Pharmaceuticals Inc. Use of certain biphenyl compounds for protection of neurons and oligodendrocytes in the treatment of multiple sclerosis (MS)
US8093302B2 (en) 2005-02-15 2012-01-10 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-β agonists
US8999289B2 (en) 2005-03-22 2015-04-07 President And Fellows Of Harvard College Treatment of protein degradation disorders
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
WO2007014273A2 (en) 2005-07-25 2007-02-01 The Board Of Trustees Of The University Of Illinois Sulfonamides as selective estrogen receptor modulators
EP1945622B1 (en) 2005-10-11 2011-12-28 University of Pittsburgh - Of the Commonwealth System of Higher Education Isotopically-labeled benzofuran compounds as imagingagents for amyloidogenic proteins
AR056690A1 (es) 2005-10-14 2007-10-17 Athersys Inc Derivados de indol como inhibidores de indol como inhibidores del receptor 3 de histamina para el tartamiento de trastornos del sueno y cognitivos obesidad y otros trastornos de snc
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
CN101374808B (zh) 2006-01-24 2011-05-25 伊莱利利公司 孕酮受体的吲哚磺酰胺调节剂
EP1984331B1 (en) 2006-02-16 2010-10-20 Schering Corporation Pyrrolidine derivatives as erk inhibitors
EP1889617A1 (en) 2006-07-11 2008-02-20 Freie Universität Berlin Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents
CA2658764A1 (en) 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
WO2008064830A1 (en) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Bicyclic and heterobicyclic derivatives, processes for preparing them and their pharmaceutical uses
WO2008082839A2 (en) 2006-12-29 2008-07-10 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics
JP2010515687A (ja) 2007-01-05 2010-05-13 ノバルティス アーゲー キネシンスピンドルタンパク質阻害剤（ｅｇ−５）としてのイミダゾール誘導体
JP5107589B2 (ja) 2007-02-13 2012-12-26 旭化成株式会社 インドール誘導体
CN101679244B (zh) 2007-04-11 2014-01-01 橘生药品工业株式会社 5元杂环衍生物及其医药用途
EP2176209A1 (en) 2007-07-20 2010-04-21 Karo Bio Ab Novel estrogen receptor ligands
AU2008285644A1 (en) 2007-08-08 2009-02-12 Neurosearch A/S Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors
EP2252799B1 (en) 2008-02-12 2014-06-11 Parker-Hannifin Corporation Flow management system for hydraulic work machine
GB0806074D0 (en) 2008-04-03 2008-05-14 Karobio Ab Novel estrogen receptor ligands
GB0806656D0 (en) 2008-04-11 2008-05-14 Karobio Ab Novel estrogen receptor ligands
GB2459133A (en) 2008-04-11 2009-10-14 Karobio Ab Therapeutic 2-(4-substituted-phenyl)-3-(cyclyl containing)-5-hydroxy-benzo[b]thiophene derivatives as estrogen receptor ligands
US8367665B2 (en) 2008-04-16 2013-02-05 Karo Bio Ab Estrogen receptor ligands
US20110039920A1 (en) 2008-04-23 2011-02-17 Chroma Therapeutics Ltd. Inhibitors of ikk-beta serine-theronine protein kinase
WO2010000372A2 (en) 2008-06-09 2010-01-07 Ludwig-Maximilians-Universität München New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases
MX2011000177A (es) * 2008-06-25 2011-06-20 Envivo Pharmaceuticals Inc Compuestos fenilo di-substituido como inhibidores de fosfodiesterasa 10.
GB0817221D0 (en) 2008-09-19 2008-10-29 Karobio Ab Novel estrogen receptor ligands
UA107784C2 (en) * 2008-12-22 2015-02-25 Pola Chem Ind Inc Inhibitor of melanin production
GB0917571D0 (en) 2009-10-07 2009-11-25 Karobio Ab Novel estrogen receptor ligands
AR078538A1 (es) 2009-10-07 2011-11-16 Karobio Ab Pirroles e imidazoles sustituidos como ligandos del receptor de estrogenos
WO2011042473A2 (en) 2009-10-07 2011-04-14 Karo Bio Ab Novel estrogen receptor ligands
JP5505616B2 (ja) 2009-12-08 2014-05-28 凸版印刷株式会社 気体分析装置
WO2012022776A1 (en) 2010-08-19 2012-02-23 Karo Bio Ab Substituted thiopenes or furans as estrogen receptor ligands
GB201105979D0 (en) 2011-04-07 2011-05-18 Karobio Ab Novel estrogen receptor ligands

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MX2014001386A (es) 2014-11-13
ZA201400708B (en) 2015-12-23
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