MX367771B - Produccion recombinante de glicosidos de esteviol. - Google Patents
Produccion recombinante de glicosidos de esteviol.Info
- Publication number
- MX367771B MX367771B MX2016005677A MX2016005677A MX367771B MX 367771 B MX367771 B MX 367771B MX 2016005677 A MX2016005677 A MX 2016005677A MX 2016005677 A MX2016005677 A MX 2016005677A MX 367771 B MX367771 B MX 367771B
- Authority
- MX
- Mexico
- Prior art keywords
- steviol glycosides
- recombinant production
- steviol
- rebaudioside
- glycosylation activity
- Prior art date
Links
- 239000004383 Steviol glycoside Substances 0.000 title abstract 3
- 229930182488 steviol glycoside Natural products 0.000 title abstract 3
- 235000019411 steviol glycoside Nutrition 0.000 title abstract 3
- 150000008144 steviol glycosides Chemical class 0.000 title abstract 3
- 235000019202 steviosides Nutrition 0.000 title abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 239000008103 glucose Substances 0.000 abstract 2
- 230000013595 glycosylation Effects 0.000 abstract 2
- 238000006206 glycosylation reaction Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229930188195 rebaudioside Natural products 0.000 abstract 2
- QFVOYBUQQBFCRH-UHFFFAOYSA-N Steviol Natural products C1CC2(C3)CC(=C)C3(O)CCC2C2(C)C1C(C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-UHFFFAOYSA-N 0.000 abstract 1
- 229930182478 glucoside Natural products 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940032084 steviol Drugs 0.000 abstract 1
- -1 steviol glucosides Chemical class 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
- A21D13/00—Finished or partly finished bakery products
- A21D13/06—Products with modified nutritive value, e.g. with modified starch content
- A21D13/062—Products with modified nutritive value, e.g. with modified starch content with modified sugar content; Sugar-free products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/38—Sucrose-free products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1062—Sucrose synthase (2.4.1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361898571P | 2013-11-01 | 2013-11-01 | |
| PCT/US2014/059081 WO2015065650A2 (en) | 2013-11-01 | 2014-10-03 | Recombinant production of steviol glycosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016005677A MX2016005677A (es) | 2016-10-28 |
| MX367771B true MX367771B (es) | 2019-09-05 |
Family
ID=53005355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016005677A MX367771B (es) | 2013-11-01 | 2014-10-03 | Produccion recombinante de glicosidos de esteviol. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20160251635A1 (de) |
| EP (1) | EP3063286B1 (de) |
| JP (1) | JP6530760B2 (de) |
| CN (1) | CN106103729B (de) |
| AU (2) | AU2014342939B2 (de) |
| CA (1) | CA2928940C (de) |
| DK (1) | DK3063286T3 (de) |
| ES (1) | ES2709439T3 (de) |
| MX (1) | MX367771B (de) |
| RU (2) | RU2706789C2 (de) |
| WO (1) | WO2015065650A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6530760B2 (ja) | 2013-11-01 | 2019-06-12 | コナゲン インコーポレーテッド | ステビオール配糖体の組換え製造 |
| US9522929B2 (en) | 2014-05-05 | 2016-12-20 | Conagen Inc. | Non-caloric sweetener |
| KR102557670B1 (ko) * | 2014-10-03 | 2023-07-20 | 코나겐 인크. | 비칼로리 감미료 및 합성 방법 |
| WO2016100689A1 (en) | 2014-12-17 | 2016-06-23 | Cargill, Incorporated | Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility |
| CA3255837A1 (en) | 2015-03-16 | 2025-10-30 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| CN113683712B (zh) | 2015-04-03 | 2022-10-21 | 帝斯曼知识产权资产管理有限公司 | 甜菊醇糖苷 |
| AU2016250184B2 (en) * | 2015-04-14 | 2020-07-30 | Conagen Inc. | Production of non-caloric sweeteners using engineered whole-cell catalysts |
| CN107614677A (zh) * | 2015-05-29 | 2018-01-19 | 嘉吉公司 | 用于使用多阶段进料生产甜菊醇糖苷的发酵方法 |
| CN105380224A (zh) * | 2015-11-19 | 2016-03-09 | 南京诺云生物科技有限公司 | 一种新型甜菊糖衍生物、制备方法及其应用 |
| CN105348337B (zh) * | 2015-11-19 | 2018-07-27 | 南京诺云生物科技有限公司 | 一种甜菊苷生物转化制备的甜菊糖衍生物、制备方法及其应用 |
| CN108884484A (zh) * | 2015-11-30 | 2018-11-23 | 谱赛科有限责任公司 | 用于制备高纯度甜菊醇糖苷的方法 |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3471744A4 (de) | 2016-06-15 | 2020-07-29 | Codexis, Inc. | Manipulierte beta-glucosidasen und glucosylierungsverfahren |
| JP7177048B2 (ja) | 2016-10-14 | 2022-11-22 | コナゲン インコーポレイテッド | ステビオール配糖体の生合成製造およびそのためのプロセス |
| CN109890973B (zh) | 2016-10-21 | 2023-05-23 | 百事可乐公司 | 一种酶法制备瑞鲍迪甙n的方法 |
| KR20260006703A (ko) | 2017-02-03 | 2026-01-13 | 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 | 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법 |
| MY202423A (en) * | 2017-03-06 | 2024-04-28 | Conagen Inc | Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e |
| MY206790A (en) * | 2017-05-15 | 2025-01-08 | Purecircle Usa Inc | High-purity steviol glycosides |
| KR102792406B1 (ko) | 2017-06-30 | 2025-04-08 | 코나겐 인크. | 베타-글루코시다제에 의한 스테비올 글리코시드의 가수분해 |
| CN109423486B (zh) * | 2017-08-29 | 2022-02-25 | 中国科学院分子植物科学卓越创新中心 | 新型udp-糖基转移酶及其应用 |
| US11365417B2 (en) | 2017-09-12 | 2022-06-21 | Bio Capital Holdings, LLC | Biological devices and methods of use thereof to produce steviol glycosides |
| CN109868265B (zh) * | 2017-12-01 | 2023-04-25 | 中国科学院分子植物科学卓越创新中心 | 新型糖基转移酶及其应用 |
| IL319918A (en) | 2018-07-30 | 2025-05-01 | Tate & Lyle Solutions Usa Llc | Engineered glycosyltransferases and methods for glycosylation of steviol glycoside |
| CA3118924A1 (en) | 2018-11-09 | 2020-05-14 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| WO2020123877A1 (en) * | 2018-12-12 | 2020-06-18 | Conagen Inc. | Biosynthetic production of variant steviol glycosides |
| CN113388014B (zh) * | 2020-03-12 | 2023-02-03 | 中科农福(北京)生物技术有限公司 | Os02g0589400蛋白在调控植物化感作用中的应用 |
| KR102628374B1 (ko) * | 2021-10-19 | 2024-01-24 | 씨제이제일제당 주식회사 | 신규한 당전이효소 및 이의 용도 |
| WO2023183832A1 (en) | 2022-03-23 | 2023-09-28 | Sweegen, Inc. | Sweetener comprising rebaudiose m and brazzein |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8277862B2 (en) * | 2007-03-14 | 2012-10-02 | Concentrate Manufacturing Company Of Ireland | Beverage products having steviol glycosides and at least one acid |
| CN101701238B (zh) * | 2009-10-14 | 2011-11-16 | 南京师范大学 | 一种由甜菊糖苷制备甜茶甙的方法 |
| CN105671108A (zh) * | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| EP2742142B2 (de) * | 2011-08-08 | 2020-03-25 | Evolva SA | Rekombinante herstellung von steviolglykosiden |
| WO2013133689A1 (en) * | 2012-03-08 | 2013-09-12 | Purecircle Sdn Bhd | High-purity rubusoside and process for producing of the same |
| CA3152828A1 (en) * | 2011-12-19 | 2013-06-27 | The Coca-Cola Company | Methods for purifying steviol glycosides and uses of the same |
| RU2499427C1 (ru) * | 2012-09-19 | 2013-11-27 | Нина Васильевна Мелишева | Композиция подсластителя |
| JP6530760B2 (ja) | 2013-11-01 | 2019-06-12 | コナゲン インコーポレーテッド | ステビオール配糖体の組換え製造 |
-
2014
- 2014-10-03 JP JP2016552419A patent/JP6530760B2/ja not_active Expired - Fee Related
- 2014-10-03 ES ES14857965T patent/ES2709439T3/es active Active
- 2014-10-03 DK DK14857965.9T patent/DK3063286T3/en active
- 2014-10-03 WO PCT/US2014/059081 patent/WO2015065650A2/en not_active Ceased
- 2014-10-03 US US15/032,286 patent/US20160251635A1/en not_active Abandoned
- 2014-10-03 RU RU2016120635A patent/RU2706789C2/ru active
- 2014-10-03 RU RU2019135831A patent/RU2741103C2/ru active
- 2014-10-03 EP EP14857965.9A patent/EP3063286B1/de active Active
- 2014-10-03 CN CN201480072126.8A patent/CN106103729B/zh active Active
- 2014-10-03 MX MX2016005677A patent/MX367771B/es active IP Right Grant
- 2014-10-03 AU AU2014342939A patent/AU2014342939B2/en not_active Ceased
- 2014-10-03 CA CA2928940A patent/CA2928940C/en active Active
-
2016
- 2016-12-01 US US15/366,209 patent/US10081826B2/en active Active
-
2017
- 2017-06-23 US US15/631,083 patent/US10253344B2/en active Active
- 2017-10-31 AU AU2017254856A patent/AU2017254856A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170081691A1 (en) | 2017-03-23 |
| AU2017254856A1 (en) | 2017-11-23 |
| RU2741103C2 (ru) | 2021-01-22 |
| EP3063286B1 (de) | 2018-12-05 |
| DK3063286T3 (en) | 2019-03-04 |
| EP3063286A2 (de) | 2016-09-07 |
| JP2017500056A (ja) | 2017-01-05 |
| CN106103729B (zh) | 2020-07-07 |
| ES2709439T3 (es) | 2019-04-16 |
| RU2016120635A3 (de) | 2018-05-31 |
| EP3063286A4 (de) | 2017-06-21 |
| JP6530760B2 (ja) | 2019-06-12 |
| WO2015065650A3 (en) | 2015-11-05 |
| CN106103729A (zh) | 2016-11-09 |
| RU2019135831A3 (de) | 2020-06-19 |
| AU2014342939B2 (en) | 2018-03-22 |
| CA2928940A1 (en) | 2015-05-07 |
| US20160251635A1 (en) | 2016-09-01 |
| US20170298404A1 (en) | 2017-10-19 |
| MX2016005677A (es) | 2016-10-28 |
| US10253344B2 (en) | 2019-04-09 |
| RU2706789C2 (ru) | 2019-11-21 |
| RU2016120635A (ru) | 2017-12-06 |
| US10081826B2 (en) | 2018-09-25 |
| RU2019135831A (ru) | 2020-01-20 |
| WO2015065650A2 (en) | 2015-05-07 |
| AU2014342939A1 (en) | 2016-05-19 |
| CA2928940C (en) | 2021-12-14 |
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