MX369480B - Procedimiento para la preparación de un complejo polipeptídico fisiológicamente activo. - Google Patents

Procedimiento para la preparación de un complejo polipeptídico fisiológicamente activo.

Info

Publication number
MX369480B
MX369480B MX2014005353A MX2014005353A MX369480B MX 369480 B MX369480 B MX 369480B MX 2014005353 A MX2014005353 A MX 2014005353A MX 2014005353 A MX2014005353 A MX 2014005353A MX 369480 B MX369480 B MX 369480B
Authority
MX
Mexico
Prior art keywords
physiologically active
active polypeptide
conjugate
peptide polymer
polypeptide complex
Prior art date
Application number
MX2014005353A
Other languages
English (en)
Other versions
MX2014005353A (es
Inventor
Dae Jin Kim
Se Chang Kwon
Myung Hyun Jang
Seung Su Kim
Jong Soo Lee
Jae Hyuk Choi
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of MX2014005353A publication Critical patent/MX2014005353A/es
Publication of MX369480B publication Critical patent/MX369480B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un procedimiento para preparar un conjugado de proteína fisiológicamente activa y un polímero no peptídico, caracterizado porque comprende: (1) hacer reaccionar la proteína fisiológicamente activa con el polímero no peptídico en la solución de reacción que comprende un disolvente orgánico para unir la proteína fisiológicamente activa con el polímero no peptídico; y (2) aislar y purificar el conjugado de proteína fisiológicamente activa unido covalentemente al polímero no peptídico de la mezcla de reacción de la etapa (1), en donde el disolvente orgánico es un alcohol que tiene de 1 a 10 átomos de carbono; la solución de reacción comprende el disolvente orgánico en una cantidad de 30% a 55% en volumen basado en el volumen total de la solución de reacción; la solución de reacción tiene el p H de 4.5 a 6.5; el polímero no peptídico tiene dos o tres grupos de extremos reactivos; y la proteína fisiológicamente activa tiene dos extremos N y es insulina.
MX2014005353A 2011-11-04 2012-11-02 Procedimiento para la preparación de un complejo polipeptídico fisiológicamente activo. MX369480B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110114828A KR20130049671A (ko) 2011-11-04 2011-11-04 생리활성 폴리펩타이드 결합체 제조 방법
PCT/KR2012/009186 WO2013066106A1 (en) 2011-11-04 2012-11-02 Method for preparing physiologically active polypeptide complex

Publications (2)

Publication Number Publication Date
MX2014005353A MX2014005353A (es) 2014-05-28
MX369480B true MX369480B (es) 2019-11-08

Family

ID=48192386

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014005353A MX369480B (es) 2011-11-04 2012-11-02 Procedimiento para la preparación de un complejo polipeptídico fisiológicamente activo.

Country Status (18)

Country Link
US (1) US11434271B2 (es)
EP (1) EP2773672B1 (es)
JP (2) JP6336394B2 (es)
KR (1) KR20130049671A (es)
CN (2) CN108210934A (es)
AR (1) AR088619A1 (es)
AU (1) AU2012331750B2 (es)
BR (1) BR112014010818A2 (es)
CA (1) CA2854078A1 (es)
ES (1) ES2898718T3 (es)
IL (1) IL232387B (es)
MX (1) MX369480B (es)
PH (1) PH12014500926B1 (es)
RU (1) RU2624129C2 (es)
SG (1) SG11201401677VA (es)
TW (1) TWI617569B (es)
WO (1) WO2013066106A1 (es)
ZA (1) ZA201403189B (es)

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PH12014500926A1 (en) 2014-06-09
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AU2012331750A1 (en) 2014-05-22
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RU2624129C2 (ru) 2017-06-30
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PH12014500926B1 (en) 2018-04-06
US20140296475A1 (en) 2014-10-02
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CA2854078A1 (en) 2013-05-10
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AR088619A1 (es) 2014-06-25
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CN108210934A (zh) 2018-06-29
JP6336394B2 (ja) 2018-06-06
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AU2012331750B2 (en) 2017-06-15
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EP2773672A4 (en) 2015-03-18
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