MX376332B - Endoproteasa especifica para prolina y usos de la misma. - Google Patents

Endoproteasa especifica para prolina y usos de la misma.

Info

Publication number
MX376332B
MX376332B MX2016015362A MX2016015362A MX376332B MX 376332 B MX376332 B MX 376332B MX 2016015362 A MX2016015362 A MX 2016015362A MX 2016015362 A MX2016015362 A MX 2016015362A MX 376332 B MX376332 B MX 376332B
Authority
MX
Mexico
Prior art keywords
polypeptide
proline
specific endoprotease
endoprotease activity
activity
Prior art date
Application number
MX2016015362A
Other languages
English (en)
Other versions
MX2016015362A (es
Inventor
Bruine-Paulus Angela De
Chantal Christis
Der Laan Jan Metske Van
Martine Spaans
De Vondervoort Peter Jozef Ida Van
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2016015362A publication Critical patent/MX2016015362A/es
Publication of MX376332B publication Critical patent/MX376332B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
    • C12C11/00—Fermentation processes for beer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con un polipéptido que tiene actividad de endoproteasa específica para prolina, en donde el polipéptido tiene menos de 70% de actividad residual cuando el polipéptido se ha mantenido a una temperatura de 65°C durante 15 minutos. La invención se relaciona además con un polipéptido que tiene actividad de endoproteasa específica para prolina que comprende una secuencia de aminoácidos de acuerdo con SEQ ID NO: 1, en donde SEQ ID NO: 1 comprende al menos una sustitución de aminoácidos seleccionada del grupo que consiste de una combinación seleccionada del grupo que consiste de P469A, P469C, P469D, P469E, P469F, P469G, P469H, P469I, P469K, P469L, P469M, P469N, P469Q, P469R, P469S, P469T, P469V, P469W, P469Y, un ácido nucleico que codifica un polipéptido que tiene actividad de endoproteasa específica para prolina, un método para fabricar un polipéptido variante que tiene actividad de endoproteasa específica para prolina, una célula hospedera recombinante y un método para producir el polipéptido y un proceso para la preparación de un producto alimenticio o de pienso en donde se utiliza el polipéptido.
MX2016015362A 2014-06-03 2015-06-03 Endoproteasa especifica para prolina y usos de la misma. MX376332B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14170879 2014-06-03
EP14172645 2014-06-17
EP14172644 2014-06-17
PCT/EP2015/062328 WO2015185593A1 (en) 2014-06-03 2015-06-03 Proline-specific endoprotease and use thereof

Publications (2)

Publication Number Publication Date
MX2016015362A MX2016015362A (es) 2017-04-13
MX376332B true MX376332B (es) 2025-03-07

Family

ID=53276885

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015362A MX376332B (es) 2014-06-03 2015-06-03 Endoproteasa especifica para prolina y usos de la misma.

Country Status (11)

Country Link
US (1) US10294467B2 (es)
EP (1) EP3152305B1 (es)
CN (1) CN106414733B (es)
BR (1) BR112016027526B1 (es)
DK (1) DK3152305T3 (es)
EA (1) EA035178B1 (es)
ES (1) ES2718071T3 (es)
MX (1) MX376332B (es)
PL (1) PL3152305T3 (es)
WO (2) WO2015185592A2 (es)
ZA (1) ZA201607700B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106459948B (zh) * 2014-06-03 2020-12-29 帝斯曼知识产权资产管理有限公司 脯氨酸特异性内切蛋白酶及其用途
WO2016120764A1 (en) * 2015-01-26 2016-08-04 Centre Hospitalier Universitaire Vaudois (Chuv) Aspergillus oryzae prolyl endopeptidases and use thereof in degradation of polypeptides
GB201705750D0 (en) * 2017-04-10 2017-05-24 Univ Oxford Innovation Ltd Peptide ligase and use therof
US20210315238A1 (en) * 2018-07-31 2021-10-14 Dupont Nutrition Biosciences Aps Proline specific endopeptidases
EP3837553A1 (en) * 2018-08-17 2021-06-23 Regeneron Pharmaceuticals, Inc. Methods for de novo protein sequencing
JPWO2022181782A1 (es) * 2021-02-26 2022-09-01
CN120957611A (zh) * 2023-03-27 2025-11-14 帝斯曼知识产权资产管理有限公司 酶组合物和啤酒酿造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1326957E (pt) * 2000-12-07 2004-09-30 Dsm Ip Assets Bv Metodo para a prevencao ou reducao de turvacao em bebidas
CA2437081C (en) * 2000-12-07 2010-10-19 Dsm Ip Assets B.V. Protein hydrolysates enriched in peptides having a carboxy terminal proline residue
EP1511835B9 (en) 2002-06-07 2015-02-25 DSM IP Assets B.V. Improved method for the prevention or reduction of haze in beverages
CN101460616A (zh) * 2006-03-30 2009-06-17 诺维信股份有限公司 具有内切葡聚糖酶活性的多肽和编码该多肽的多核苷酸
WO2012174127A1 (en) * 2011-06-17 2012-12-20 Alvine Pharmaceuticals, Inc. Proteases for degrading gluten
RU2014150072A (ru) * 2012-05-11 2016-07-10 Новозимс А/С Способ пивоварения

Also Published As

Publication number Publication date
BR112016027526B1 (pt) 2024-01-30
MX2016015362A (es) 2017-04-13
ZA201607700B (en) 2018-04-25
WO2015185592A3 (en) 2016-02-11
EA201692439A1 (ru) 2017-04-28
EP3152305B1 (en) 2019-02-27
CN106414733A (zh) 2017-02-15
WO2015185593A1 (en) 2015-12-10
BR112016027526A2 (pt) 2017-10-17
WO2015185592A2 (en) 2015-12-10
ES2718071T3 (es) 2019-06-27
CN106414733B (zh) 2021-04-23
US20170198272A1 (en) 2017-07-13
EP3152305A1 (en) 2017-04-12
EA035178B1 (ru) 2020-05-12
PL3152305T3 (pl) 2019-07-31
DK3152305T3 (da) 2019-05-20
US10294467B2 (en) 2019-05-21

Similar Documents

Publication Publication Date Title
MX2018016114A (es) Una novedosa fructosa-6-fosfato-3-epimerasa termoestable y un procedimiento para producir alulosa mediante el uso de la misma.
WO2015185592A3 (en) Proline-specific endoprotease and use thereof
MX2023001394A (es) Genes del factor viii optimizados.
WO2014202616A3 (en) Rasamsonia gene and use thereof
PH12018501355A1 (en) Rsv f protein mutants
WO2016046234A3 (en) Recombinant phe-free proteins for use in the treatment of phenylketonuria
BR112016020517A2 (pt) método de produção de lipídeo através da utilização de ss-cetoacil-acp sintase
WO2015027258A3 (de) Polypeptid zur hydrolytischen spaltung von zearalenon und/oder zearalenon-derivaten, isoliertes polynukleotid davon sowie einen zusatzstoff enthaltendes polypeptid, verwendung desselben sowie verfahren
EP4223772A3 (en) Optimized factor viii gene
MX2022005119A (es) Metodos de reduccion de olor.
MX2019000082A (es) Una novedosa tagatosa-6-fosfato fosfatasa termoestable y un procedimiento para producir tagatosa usando la misma.
MX2016009149A (es) Variantes mejoradas de enzimas.
MY189932A (en) Recombinant microorganism for improved production of alanine
MX2024013590A (es) Adnc del antagonista del receptor de interleucina-1
WO2015107363A3 (en) Mycobacterial antigen composition
NZ742660A (en) Variants of chymosin with improved milk-clotting properties
PH12018500155A1 (en) Recombinant orf virus vector
WO2014122161A3 (en) Use of polypeptides having protease activity in animal feed
EP3760713A3 (en) Lipase variants and polynucleotides encoding same
MX2017000014A (es) Metodo para producir acido graso de cadena media con el uso de beta-cetoacil-proteina portadora de acilo (acp) sintasa.
MY169049A (en) Microorganisms for producing putrescine and process for producing putrescine using them
MX375798B (es) Endoproteasa específica para prolina.
EP3925968A3 (en) Hsp70-derived peptide, pharmaceutical composition for treating or preventing cancer using same, immunity inducer, and method for producing antigen-presenting cell
NZ709120A (en) Beta-hexosyl-transferases and uses thereof
MY200951A (en) Variants Of Porcine Trypsin

Legal Events

Date Code Title Description
FG Grant or registration