MX377667B - Uso de un agonista de malatonina para el tratamiento de ritmos circadianos de curso libre. - Google Patents
Uso de un agonista de malatonina para el tratamiento de ritmos circadianos de curso libre.Info
- Publication number
- MX377667B MX377667B MX2015007909A MX2015007909A MX377667B MX 377667 B MX377667 B MX 377667B MX 2015007909 A MX2015007909 A MX 2015007909A MX 2015007909 A MX2015007909 A MX 2015007909A MX 377667 B MX377667 B MX 377667B
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- circadian rhythm
- rhythm disorders
- patients
- circadian
- Prior art date
Links
- 208000017164 Chronobiology disease Diseases 0.000 title 1
- 230000027288 circadian rhythm Effects 0.000 abstract 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- 230000008447 perception Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
- A61K31/31—Mercury compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2864—Sleep disorders
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Primary Health Care (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Las modalidades de la invención se refieren al uso de un agonista de melatonina en el tratamiento de ritmos circadianos de curso libre en los pacientes, incluidos pacientes con deficiencia de percepción de la luz, por ejemplo, pacientes ciegos, y a métodos para medir el ritmo circadiano.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261738987P | 2012-12-18 | 2012-12-18 | |
| US201261738985P | 2012-12-18 | 2012-12-18 | |
| US201361755896P | 2013-01-23 | 2013-01-23 | |
| US13/751,011 US8785492B2 (en) | 2012-01-26 | 2013-01-25 | Treatment of circadian rhythm disorders |
| PCT/US2013/023315 WO2013112951A2 (en) | 2012-01-26 | 2013-01-25 | Treatment of circadian rhythm disorders |
| US201361903354P | 2013-11-12 | 2013-11-12 | |
| PCT/US2013/076311 WO2014100292A1 (en) | 2012-12-18 | 2013-12-18 | Treatment of circadian rhythm disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015007909A MX2015007909A (es) | 2016-04-25 |
| MX377667B true MX377667B (es) | 2025-03-11 |
Family
ID=50979184
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015007909A MX377667B (es) | 2012-12-18 | 2013-12-18 | Uso de un agonista de malatonina para el tratamiento de ritmos circadianos de curso libre. |
| MX2019006218A MX2019006218A (es) | 2012-12-18 | 2015-06-18 | Tratamiento de trastornos del ritmo circadiano. |
| MX2020012689A MX2020012689A (es) | 2012-12-18 | 2015-06-18 | Tratamiento de trastornos del ritmo circadiano. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006218A MX2019006218A (es) | 2012-12-18 | 2015-06-18 | Tratamiento de trastornos del ritmo circadiano. |
| MX2020012689A MX2020012689A (es) | 2012-12-18 | 2015-06-18 | Tratamiento de trastornos del ritmo circadiano. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9730910B2 (es) |
| EP (2) | EP2934509B1 (es) |
| JP (4) | JP6144358B2 (es) |
| KR (4) | KR20150093236A (es) |
| CN (2) | CN110200958A (es) |
| AU (5) | AU2013361459A1 (es) |
| BR (1) | BR112015014619A2 (es) |
| CA (2) | CA2893542C (es) |
| CL (1) | CL2015001700A1 (es) |
| ES (1) | ES2805376T3 (es) |
| IL (2) | IL266159B2 (es) |
| MX (3) | MX377667B (es) |
| RU (1) | RU2748386C2 (es) |
| WO (1) | WO2014100292A1 (es) |
| ZA (1) | ZA201504579B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090105333A1 (en) * | 2006-05-22 | 2009-04-23 | Gunther Birznieks | Melatonin agonist treatment |
| KR102593047B1 (ko) | 2012-01-26 | 2023-10-24 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
| US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| WO2014100292A1 (en) * | 2012-12-18 | 2014-06-26 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| WO2015117048A1 (en) * | 2014-01-31 | 2015-08-06 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
| RS61645B1 (sr) | 2015-10-30 | 2021-04-29 | Neurocrine Biosciences Inc | Valbenazin ditozilat i njihovi polimorfi |
| JP6869988B2 (ja) | 2015-12-23 | 2021-05-12 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | (S)−(2R,3R,11bR)−3−イソブチル−9,10−ジメトキシ−2,3,4,6,7,11b−ヘキサヒドロ−1H−ピリド[2,1−a]イソキノリン−2−イル2−アミノ−3−メチルブタノエートジ(4−メチルベンゼンスルホネート)の調製のための合成方法 |
| CA3051830A1 (en) | 2017-01-27 | 2018-08-02 | Neurocrine Bioscienes, Inc. | Methods for the administration of certain vmat2 inhibitors |
| WO2019028245A1 (en) | 2017-08-02 | 2019-02-07 | Vanda Pharmaceuticals Inc. | USE OF TASIMELTÉON FOR THE TREATMENT OF AFFECTIVE DISORDERS |
| CA3076000A1 (en) | 2017-09-21 | 2019-03-28 | Neurocrine Biosciences, Inc. | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
| JP2021502959A (ja) | 2017-10-10 | 2021-02-04 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 特定のvmat2インヒビターを投与するための方法 |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| MA53239A (fr) | 2018-08-15 | 2022-05-04 | Neurocrine Biosciences Inc | Procédés d'administration de certains inhibiteurs de vmat2 |
| EP3671757A1 (en) * | 2018-12-18 | 2020-06-24 | Koninklijke Philips N.V. | System and method for determining a level of alertness |
| CA3129833C (en) | 2019-02-13 | 2023-01-17 | Vanda Pharmaceuticals Inc. | Method of improving sleep |
| JP6722911B1 (ja) * | 2019-04-18 | 2020-07-15 | 株式会社こどもみらい | 個人別の概日リズムに基づく生活時刻の提示システム |
| JP7348613B2 (ja) * | 2019-04-18 | 2023-09-21 | 株式会社こどもみらい | 個人別の概日リズムに基づく生活時刻の提示システム |
| AU2020299168B2 (en) * | 2019-06-29 | 2024-05-09 | Vanda Pharmaceuticals Inc. | Tasimelteon use in treating sleep aberrations |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| AU2020400065B2 (en) | 2019-12-13 | 2025-08-14 | Vanda Pharmaceuticals Inc. | Liquid tasimelteon formulations and methods of use thereof |
| US20260108184A1 (en) * | 2024-02-27 | 2026-04-23 | Lume Health Technologies Inc. | Systems and methods for wearable sensing platform |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL50699A0 (en) | 1975-10-28 | 1976-12-31 | Ici America Inc | Triazole derivatives |
| DE3466215D1 (en) | 1983-05-18 | 1987-10-22 | Univ Monash | The use of melatonin for the manufacture of a medicament |
| IL79264A0 (en) | 1986-06-27 | 1986-09-30 | Univ Ramot | Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors |
| US4997845A (en) | 1987-02-02 | 1991-03-05 | Eli Lilly And Company | β-alkylmelatonins as ovulation inhibitors |
| US5093352A (en) | 1988-11-14 | 1992-03-03 | Whitby Research, Inc. | Antidepressant agents |
| US5151446A (en) | 1989-09-25 | 1992-09-29 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
| FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| IT1251544B (it) | 1991-05-13 | 1995-05-17 | Gabriele Biella | Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico |
| US6180657B1 (en) | 1993-11-18 | 2001-01-30 | Eli Lilly And Company | Melatonin derivatives for use in treating desynchronization disorders |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| GB9416884D0 (en) | 1994-08-20 | 1994-10-12 | Danbiosyst Uk | Drug delivery compositions |
| MD1716C2 (ro) | 1995-02-01 | 2002-02-28 | Neurim Pharmaceuticals (1991) Ltd. | Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine |
| CA2235803A1 (en) * | 1995-10-24 | 1997-05-01 | The Trustees Of The University Of Pennsylvania | Method of adjusting the circadian rhythm of a mammal |
| RU2190609C2 (ru) | 1996-12-10 | 2002-10-10 | Бристол-Маерс Сквибб Компани | Производные бензодиоксола, бензофурана, дигидробензофурана и бензодиоксана и содержащие их композиции |
| US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
| AUPO588297A0 (en) | 1997-03-26 | 1997-04-24 | Luminis Pty Limited | Mediation in melatonin production |
| EP1100508B8 (en) | 1998-06-09 | 2004-01-07 | Takeda Chemical Industries, Ltd. | Pharmaceutical combination comprising a tricyclic compound and at least one of zolpidem, zopiclone and brotizolam for treating or preventing sleep disorders |
| US6562858B2 (en) | 1999-05-17 | 2003-05-13 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating depression |
| DE60007745T2 (de) | 1999-06-30 | 2005-03-10 | Bristol-Myers Squibb Co. | Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe |
| BRPI0213564B8 (pt) | 2001-10-30 | 2021-05-25 | Novartis Ag | formulação depósito e micropartícula compreendendo iloperidona e polímero poli(d,l-lactídeo-co-glicolídeo), e processo para preparação da referida micropartícula |
| GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
| IL155666A (en) * | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
| JP2005080603A (ja) | 2003-09-10 | 2005-03-31 | Kumamoto Technology & Industry Foundation | 生体リズム障害の度合の判断方法 |
| US20050137247A1 (en) | 2003-12-22 | 2005-06-23 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of hypertension |
| EP1696959A2 (en) | 2003-12-24 | 2006-09-06 | Sepracor, Inc. | Melatonin combination therapy for improving sleep quality |
| WO2007016203A1 (en) | 2005-07-29 | 2007-02-08 | Vanda Pharmaceuticals, Inc. | Method of improving wakefulness |
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| WO2007137247A2 (en) | 2006-05-22 | 2007-11-29 | Vanda Pharmaceuticals, Inc. | Treatment for depressive disorders |
| US20090105333A1 (en) * | 2006-05-22 | 2009-04-23 | Gunther Birznieks | Melatonin agonist treatment |
| WO2009036257A1 (en) | 2007-09-13 | 2009-03-19 | Vanda Pharmaceuticals, Inc. | Prediction of sleep parameter and response to sleep-inducing compound based on per3 vntr genotype |
| WO2009084023A2 (en) | 2007-10-19 | 2009-07-09 | Glenmark Generics Limited | Amorphous ramelteon and process for the preparation thereof |
| JP5558016B2 (ja) * | 2009-03-17 | 2014-07-23 | 株式会社 資生堂 | 概日リズム調整剤 |
| US20120136050A1 (en) | 2009-07-16 | 2012-05-31 | Vanda Pharmaceuticals Inc. | Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia |
| KR102593047B1 (ko) | 2012-01-26 | 2023-10-24 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
| WO2014100292A1 (en) * | 2012-12-18 | 2014-06-26 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
-
2013
- 2013-12-18 WO PCT/US2013/076311 patent/WO2014100292A1/en not_active Ceased
- 2013-12-18 KR KR1020157018602A patent/KR20150093236A/ko not_active Ceased
- 2013-12-18 IL IL266159A patent/IL266159B2/en unknown
- 2013-12-18 JP JP2015549658A patent/JP6144358B2/ja active Active
- 2013-12-18 RU RU2015129349A patent/RU2748386C2/ru active
- 2013-12-18 BR BR112015014619A patent/BR112015014619A2/pt not_active Application Discontinuation
- 2013-12-18 EP EP13817826.4A patent/EP2934509B1/en active Active
- 2013-12-18 KR KR1020207024197A patent/KR102269761B1/ko active Active
- 2013-12-18 CA CA2893542A patent/CA2893542C/en active Active
- 2013-12-18 CA CA3158157A patent/CA3158157A1/en active Pending
- 2013-12-18 AU AU2013361459A patent/AU2013361459A1/en not_active Abandoned
- 2013-12-18 CN CN201910541736.2A patent/CN110200958A/zh active Pending
- 2013-12-18 MX MX2015007909A patent/MX377667B/es active IP Right Grant
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