MX382488B - Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas. - Google Patents

Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.

Info

Publication number
MX382488B
MX382488B MX2017005186A MX2017005186A MX382488B MX 382488 B MX382488 B MX 382488B MX 2017005186 A MX2017005186 A MX 2017005186A MX 2017005186 A MX2017005186 A MX 2017005186A MX 382488 B MX382488 B MX 382488B
Authority
MX
Mexico
Prior art keywords
neural stem
growth factor
stem cells
exogenous polynucleotide
methods
Prior art date
Application number
MX2017005186A
Other languages
English (en)
Spanish (es)
Other versions
MX2017005186A (es
Inventor
Karl K Johe
Thomas Hazel
Original Assignee
Neuralstem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuralstem Inc filed Critical Neuralstem Inc
Publication of MX2017005186A publication Critical patent/MX2017005186A/es
Publication of MX382488B publication Critical patent/MX382488B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
MX2017005186A 2014-10-20 2015-10-19 Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas. MX382488B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462066174P 2014-10-20 2014-10-20
US201562147950P 2015-04-15 2015-04-15
PCT/US2015/056226 WO2016064737A1 (fr) 2014-10-20 2015-10-19 Cellules souches neurales stables comprenant un polynucléotide exogène codant pour un facteur de croissance et leurs méthodes d'utilisation

Publications (2)

Publication Number Publication Date
MX2017005186A MX2017005186A (es) 2017-07-26
MX382488B true MX382488B (es) 2025-03-13

Family

ID=55761367

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005186A MX382488B (es) 2014-10-20 2015-10-19 Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.

Country Status (9)

Country Link
US (2) US9750769B2 (fr)
EP (1) EP3209306B1 (fr)
JP (2) JP6983069B2 (fr)
KR (2) KR20190060016A (fr)
CN (1) CN107148275A (fr)
AU (2) AU2015336194B2 (fr)
CA (1) CA2964927C (fr)
MX (1) MX382488B (fr)
WO (1) WO2016064737A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250022877A (ko) * 2017-01-31 2025-02-17 리젠엑스바이오 인크. 완전히-인간 글리코실화된 인간 알파-l-이두로니다아제(idua)를 이용한 뮤코다당증 1형의 치료
KR102245539B1 (ko) 2018-02-12 2021-04-29 주식회사 지앤피바이오사이언스 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물
WO2019165306A1 (fr) * 2018-02-23 2019-08-29 Regeneration Biomedical, Inc. Procédés, appareils et systèmes d'instillation de cellules souches et de produits pharmaceutiques dans le système ventriculaire humain
CN112469732A (zh) * 2018-07-17 2021-03-09 赫利世弥斯株式会社 使用胰岛素样生长因子1-加密脱氧核糖核酸构建体及肝细胞生长因子-加密脱氧核糖核酸构建体的神经病变治疗
EP3823981A4 (fr) * 2018-07-17 2022-04-06 Neuromyon Inc. Traitement de neuropathie avec des constructions d'adn exprimant des isoformes d'igf-1
EP3852771A4 (fr) 2018-09-19 2022-06-08 Regeneration Biomedical, Inc. Appareils, procédés et systèmes de cellules souches à wnt activée dérivées du tissu adipeux
KR20210077634A (ko) * 2019-12-17 2021-06-25 코아스템(주) 인간 만능 줄기세포로부터 3d 오가노이드를 이용하여 미세교세포를 다량 확보하는 미세교세포의 분화방법
CN111388654A (zh) * 2020-05-22 2020-07-10 南通大学 治疗脊髓损伤的药物、药物试剂盒及方法
WO2023158214A1 (fr) * 2022-02-15 2023-08-24 주식회사 헬릭스미스 Composition de prévention ou traitement de la sarcopénie à l'aide d'une isoforme du facteur de croissance 1 de type insuline

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0233838A3 (fr) 1986-02-04 1990-01-31 Incyte Pharmaceuticals, Inc. Facteur stimulant les neurites, et procédé de préparation
US4753635A (en) 1986-05-23 1988-06-28 Jacqueline Sagen Inducing analgesia by implantation of cells releasing neuroactive substances
NZ226750A (en) 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
AU623922B2 (en) 1988-08-04 1992-05-28 Amrad Operations Pty. Limited In vitro propagation of embryonic stem cells
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US4980174A (en) 1988-12-23 1990-12-25 Jacqueline Sagen Method for alleviating depression
US5093317A (en) * 1989-06-05 1992-03-03 Cephalon, Inc. Treating disorders by application of insulin-like growth factor
AU6174490A (en) 1989-08-04 1991-03-11 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
WO1991009936A1 (fr) 1989-12-26 1991-07-11 Hana Biologics, Inc. Produit cellulaire progeniteur neuronal proliferee et procede
US5411883A (en) 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
US5196315A (en) 1990-05-01 1993-03-23 The Johns Hopkins University Human neuronal cell line
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
DK0594669T4 (da) 1991-07-08 2008-04-21 Neurospheres Holdings Ltd Neurale progenitorceller, som reagerer på vækstfaktorer og kan formeres in vitro
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5981165A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US7361505B1 (en) 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
US6497872B1 (en) 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
US6399369B1 (en) 1991-07-08 2002-06-04 Neurospheres Holdings Ltd. Multipotent neural stem cell cDNA libraries
US6071889A (en) 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US5175103A (en) 1991-10-21 1992-12-29 Trustees Of University Of Pennsylvania Preparation of pure cultures of post-mitotic human neurons
EP0625050B1 (fr) 1991-11-22 1999-04-14 Genentech, Inc. Tgf-beta pour ameliorer la recuperation des neurones
US5672499A (en) 1992-07-27 1997-09-30 California Institute Of Technology Immoralized neural crest stem cells and methods of making
NZ256154A (en) 1992-07-27 1997-02-24 California Inst Of Techn Production of mammalian multipotent neural stem cells, antibodies
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
AU4995193A (en) 1992-08-04 1994-03-03 Regeneron Pharmaceuticals, Inc. Method of enhancing differentiation and survival of neuronal precursor cells
WO1994004675A2 (fr) 1992-08-19 1994-03-03 Richard Kroczek Sequence d'adn codant un nouvel element de la famille des recepteurs d'hormoes steroides et thyroidiennes
KR950704476A (ko) 1992-10-28 1995-11-20 브렌드 레이놀즈 생물학적 인자 및 신경 간세포(biological factors and neural stem cells)
CN1141058A (zh) 1993-11-09 1997-01-22 纽罗斯菲里斯控股有限公司 中枢神经系统干细胞的原位修饰和处理
ES2167461T3 (es) 1994-09-23 2002-05-16 Neurospheres Holdings Ltd Modelos in vitro de funcion y disfuncion del sistema nervioso central.
FI971956L (fi) 1994-11-14 1997-07-04 Neurospheres Holdings Ltd Hermosolujen lisääntymisen säännöstely
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5753505A (en) 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US5770414A (en) 1996-02-20 1998-06-23 The Regents Of The University Of California Regulatable retrovirus system for genetic modification of cells
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
WO1998048001A1 (fr) 1997-04-24 1998-10-29 California Institute Of Technology Procedes de differenciation de cellules neurales souches
JP4371179B2 (ja) 1997-07-04 2009-11-25 ユニバーシティー オブ ユタ リサーチ ファンデーション 系列限定ニューロン前駆体
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US5932473A (en) 1997-09-30 1999-08-03 Becton Dickinson And Company Preparation of a cell culture substrate coated with poly-D-lysine
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
AU755849B2 (en) 1998-09-22 2002-12-19 Neuralstem Biopharmaceuticals, Ltd. Stable neural stem cell lines
US6284539B1 (en) 1998-10-09 2001-09-04 Neuralstem Biopharmaceuticals, Ltd. Method for generating dopaminergic cells derived from neural precursors
US6531464B1 (en) 1999-12-07 2003-03-11 Inotek Pharmaceutical Corporation Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives
US7250294B2 (en) * 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
CA2444214A1 (fr) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Inhibiteurs d'agregation de plaque amyloide et agents d'imagerie diagnostique
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
PT1590467E (pt) * 2003-01-28 2010-01-05 Hoffmann La Roche Utilização de sequências reguladoras para expressão específica transiente em células determinadas neuronais
CA2539947A1 (fr) * 2003-09-24 2005-04-07 The Board Of Trustees Of The Leland Stanford Junior University Igf-1 forme des cellules souches nerveuses du systeme nerveux central adultes pluripotentes a une lignee oligodendrogliale
EP1814979B1 (fr) 2004-11-17 2015-04-08 Neuralstem, Inc. Transplantation de cellules neurales humaines pour traiter des troubles neurodegeneratifs
US7833513B2 (en) * 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
AU2007217016A1 (en) * 2006-02-21 2007-08-30 Jeffrey Schwartz High-yield activation of polymer surfaces for covalent attachment of molecules
MX2010003371A (es) * 2007-09-28 2010-05-05 Intrexon Corp Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos.
WO2010018996A2 (fr) * 2008-08-12 2010-02-18 연세대학교 산학협력단 Cellules souches neurales humaines et préparation pharmaceutique pour le traitement de troubles et lésions des systèmes nerveux central et périphérique l'utilisant
US9657329B2 (en) * 2011-11-07 2017-05-23 The Broad Institute Inc. Propeptide-luciferase fusion proteins and methods of use thereof
CN102604894B (zh) * 2012-02-29 2014-07-30 中国科学院广州生物医药与健康研究院 用于制备神经干细胞的培养基及其用途
WO2014138003A1 (fr) * 2013-03-04 2014-09-12 Neuralstem, Inc. Compositions comprenant un médicament immunosuppresseur et/ou des cellules souches neurales et procédés pour les utiliser pour le traitement de maladies et/ou troubles neurodégénératifs

Also Published As

Publication number Publication date
MX2017005186A (es) 2017-07-26
EP3209306A1 (fr) 2017-08-30
CA2964927C (fr) 2019-07-30
CA2964927A1 (fr) 2016-04-28
KR20190060016A (ko) 2019-05-31
EP3209306A4 (fr) 2018-07-04
AU2015336194B2 (en) 2019-01-03
US20170319625A1 (en) 2017-11-09
AU2015336194A1 (en) 2017-05-04
US20160120942A1 (en) 2016-05-05
CN107148275A (zh) 2017-09-08
JP2017532068A (ja) 2017-11-02
JP6983069B2 (ja) 2021-12-17
AU2018279014A1 (en) 2019-01-17
US10702555B2 (en) 2020-07-07
KR20170067884A (ko) 2017-06-16
EP3209306B1 (fr) 2024-04-24
US9750769B2 (en) 2017-09-05
KR102100021B1 (ko) 2020-04-13
WO2016064737A1 (fr) 2016-04-28
JP2021045156A (ja) 2021-03-25

Similar Documents

Publication Publication Date Title
MX382488B (es) Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.
PH12017500402A1 (en) Anti-glucagon antibodies and uses thereof
MX394103B (es) Anticuerpos anti-angptl8 y usos de estos.
PH12016500783A1 (en) Suspension and clustering of human pluripotent stem cells for differentation into pancreatic endocrine cells
MY186702A (en) Compositions and methods of use for treating metabolic disorders
EA202090931A2 (ru) Композиции и способы перепрограммирования tcr с помощью гибридных белков
MX2019013670A (es) Formulaciones de anticuerpos y proteinas.
PH12017502283A1 (en) A method of treatment
MY194587A (en) Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration
EA201791508A1 (ru) Способы трансдифференцировки и способы их использования
EA201891919A1 (ru) Способы трансфекции растений и сокращения событий случайной интеграции
EA201691754A1 (ru) Рекомбинантный микроорганизм, экспрессирующий аналог авермектина, и его применение
EA201892624A1 (ru) Растения, дающие бессемянные плоды
UY35438A (es) Procedimiento para preparar inhibidores de la glucosilceramida sintasa.
EA201890439A1 (ru) ИММУНООНКОЛОГИЧЕСКАЯ МЕЗОДЕРМАЛЬНАЯ КЛЕТКА-ПРЕДШЕСТВЕННИК (ioMP-КЛЕТКА)
PH12019500949A1 (en) Ror-gamma modulators
EA201592265A1 (ru) Маркер для ассоциированных с кислой сфингомиелиназой нарушений и его применения
MX2021013879A (es) Variantes de lipasa y polinucleotidos que las codifican.
BR112015028737A2 (pt) métodos para a produção e/ou purificação de hormônios
BR112017011513A2 (pt) tratamento de condições oculares usando células progenitoras
CL2017001523A1 (es) Supresion parental rnai del gen hunchback para el control de plagas de coleopteros
PH12016500708B1 (en) Recombinant glycoproteins and uses thereof
EA201792603A1 (ru) Ангиогенез с использованием стимулированных плацентарных стволовых клеток
CL2017001522A1 (es) Supresion parental rnai del gen kruppel para el control de plagas de coleopteros
TW201613623A (en) Methods to enhance nerve regeneration utilizing neural stem cells and IL12p40