MX383347B - Método para incrementar la velocidad de producción específica de células eucariotas. - Google Patents

Método para incrementar la velocidad de producción específica de células eucariotas.

Info

Publication number
MX383347B
MX383347B MX2017000715A MX2017000715A MX383347B MX 383347 B MX383347 B MX 383347B MX 2017000715 A MX2017000715 A MX 2017000715A MX 2017000715 A MX2017000715 A MX 2017000715A MX 383347 B MX383347 B MX 383347B
Authority
MX
Mexico
Prior art keywords
increasing
eukaryotic cells
production rate
specific production
specific productivity
Prior art date
Application number
MX2017000715A
Other languages
English (en)
Other versions
MX2017000715A (es
Inventor
Oliver Popp
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51298668&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX383347(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2017000715A publication Critical patent/MX2017000715A/es
Publication of MX383347B publication Critical patent/MX383347B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a el uso de meta-tirosina para incrementar la productividad específica de una célula eucariota que produce/expresa un polipéptido. En el método actual, no es necesario realizar un cambio de temperatura, osmolalidad o pH o añadir fármacos como ácido valproico o butirato de sodio para modular la productividad específica de las células cultivadas. El método no afecta la viabilidad de las células o el título del producto.
MX2017000715A 2014-08-11 2015-07-31 Método para incrementar la velocidad de producción específica de células eucariotas. MX383347B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14180586 2014-08-11
PCT/EP2015/067733 WO2016023775A1 (en) 2014-08-11 2015-07-31 Method for increasing the specific production rate of eukaryotic cells

Publications (2)

Publication Number Publication Date
MX2017000715A MX2017000715A (es) 2017-04-27
MX383347B true MX383347B (es) 2025-03-13

Family

ID=51298668

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017000715A MX383347B (es) 2014-08-11 2015-07-31 Método para incrementar la velocidad de producción específica de células eucariotas.

Country Status (11)

Country Link
US (3) US10336983B2 (es)
EP (1) EP3180422B2 (es)
JP (1) JP6697442B2 (es)
KR (1) KR102467730B1 (es)
CN (1) CN106661557B (es)
BR (1) BR112016030659B1 (es)
CA (1) CA2953450C (es)
MX (1) MX383347B (es)
RU (1) RU2725191C2 (es)
SG (1) SG11201700908TA (es)
WO (1) WO2016023775A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX383347B (es) 2014-08-11 2025-03-13 Hoffmann La Roche Método para incrementar la velocidad de producción específica de células eucariotas.
CN111233996A (zh) * 2020-01-20 2020-06-05 北京交通大学 一种将丁酸钠用于促进工程细胞株分泌表达rhIL-24的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY143847A (en) * 2001-08-04 2011-07-15 Samsung Electronics Co Ltd Method and apparatus for recording and reproducing video data, and information storage medium in which video data is recorded by the same
US7807409B2 (en) * 2005-10-21 2010-10-05 Roche Palo Alto Llc Method for the recombinant expression of a polypeptide
WO2008136398A1 (ja) * 2007-04-26 2008-11-13 Chugai Seiyaku Kabushiki Kaisha 高濃度アミノ酸含有培地を用いた細胞の培養方法
RU2010102810A (ru) * 2007-06-29 2011-08-10 Ф.Хоффманн-Ля Рош Аг (Ch) Клетки сно
WO2009051109A1 (ja) * 2007-10-15 2009-04-23 Chugai Seiyaku Kabushiki Kaisha 異種タンパク質を高生産する細胞の作製方法
ES2548294T3 (es) * 2007-10-24 2015-10-15 Chugai Seiyaku Kabushiki Kaisha Célula para su uso en la producción de proteína exógena, y procedimiento de producción usando la célula
US20110262965A1 (en) * 2010-04-23 2011-10-27 Life Technologies Corporation Cell culture medium comprising small peptides
PL2563906T3 (pl) * 2010-04-26 2018-04-30 Novartis Ag Sposób hodowli komórek cho
MX383347B (es) 2014-08-11 2025-03-13 Hoffmann La Roche Método para incrementar la velocidad de producción específica de células eucariotas.

Also Published As

Publication number Publication date
US20200080048A1 (en) 2020-03-12
RU2017105852A3 (es) 2019-02-11
JP6697442B2 (ja) 2020-05-20
US10336983B2 (en) 2019-07-02
CN106661557B (zh) 2022-01-18
CN106661557A (zh) 2017-05-10
RU2017105852A (ru) 2018-09-13
US12338456B2 (en) 2025-06-24
KR102467730B1 (ko) 2022-11-15
JP2017523798A (ja) 2017-08-24
EP3180422B1 (en) 2018-10-17
US20230081499A1 (en) 2023-03-16
BR112016030659B1 (pt) 2023-04-11
CA2953450A1 (en) 2016-02-18
EP3180422A1 (en) 2017-06-21
WO2016023775A1 (en) 2016-02-18
SG11201700908TA (en) 2017-03-30
EP3180422B2 (en) 2021-11-17
CA2953450C (en) 2023-01-10
RU2725191C2 (ru) 2020-06-30
KR20170040250A (ko) 2017-04-12
BR112016030659A2 (es) 2017-08-22
MX2017000715A (es) 2017-04-27
US20170152473A1 (en) 2017-06-01

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