MX384232B - Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones. - Google Patents

Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones.

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Publication number
MX384232B
MX384232B MX2015011462A MX2015011462A MX384232B MX 384232 B MX384232 B MX 384232B MX 2015011462 A MX2015011462 A MX 2015011462A MX 2015011462 A MX2015011462 A MX 2015011462A MX 384232 B MX384232 B MX 384232B
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MX
Mexico
Prior art keywords
cholestosome
loaded
present
patient
molecules
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MX2015011462A
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English (en)
Other versions
MX2015011462A (es
Inventor
Julie Hughes
Mary P Mccourt
Lawrence Mielnicki
Jerome J Schentag
Original Assignee
Jerome J Schentag
Julie Hughes
Mary P Mccourt
Lawrence Mielnicki
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51581747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX384232(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jerome J Schentag, Julie Hughes, Mary P Mccourt, Lawrence Mielnicki filed Critical Jerome J Schentag
Publication of MX2015011462A publication Critical patent/MX2015011462A/es
Publication of MX384232B publication Critical patent/MX384232B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

La presente invención está dirigida a una nanopartícula de éster de colesterilo portadora de carga, con un compartimento hueco (cholestosome: colestosoma), que esencialmente consiste en al menos un éster de colesterilo no iónico y una o más moléculas activas encapsuladas, el cual no puede pasar apreciablemente a través de una membrana enterocítica en ausencia de la molécula que se carga en el colestosoma, el colestosoma tiene una superficie neutra y la capacidad de pasar a los enterocitos como lo hacen los lípidos nutrientes absorbidos por vía oral que utilizan las vías celulares para llegar al aparato de Golgi. Según la presente invención, los nuevos colestosomas portadores de carga según la presente invención, tienen la capacidad de depositar moléculas activas dentro de las células de un paciente o de un individuo y realizar tratamiento o diagnóstico en el paciente o el individuo.
MX2015011462A 2013-03-14 2014-03-14 Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones. MX384232B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783003P 2013-03-14 2013-03-14
PCT/US2014/027761 WO2014152795A2 (en) 2013-03-14 2014-03-14 Cholestosome vesicles for incorporation of molecules into chylomicrons

Publications (2)

Publication Number Publication Date
MX2015011462A MX2015011462A (es) 2016-05-31
MX384232B true MX384232B (es) 2025-03-14

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ID=51581747

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MX2015011462A MX384232B (es) 2013-03-14 2014-03-14 Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones.

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US (6) US9693968B2 (es)
EP (1) EP2970369B1 (es)
JP (2) JP2016513712A (es)
CN (1) CN105164143B (es)
AU (1) AU2014236559B2 (es)
BR (1) BR112015022936A2 (es)
CA (1) CA2905108C (es)
IL (1) IL241501B (es)
MX (1) MX384232B (es)
WO (1) WO2014152795A2 (es)

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