MX419987B - Nanoparticulas radioluminiscentes de sesquioxido de lutecio-177 funcionalizadas con peptidos para imagen optica. - Google Patents
Nanoparticulas radioluminiscentes de sesquioxido de lutecio-177 funcionalizadas con peptidos para imagen optica.Info
- Publication number
- MX419987B MX419987B MX2021005088A MX2021005088A MX419987B MX 419987 B MX419987 B MX 419987B MX 2021005088 A MX2021005088 A MX 2021005088A MX 2021005088 A MX2021005088 A MX 2021005088A MX 419987 B MX419987 B MX 419987B
- Authority
- MX
- Mexico
- Prior art keywords
- lutetium
- sesquioxide
- nanoparticles
- sizes
- vivo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F17/00—Compounds of rare earth metals
- C01F17/20—Compounds containing only rare earth metals as the metal element
- C01F17/206—Compounds containing only rare earth metals as the metal element oxide or hydroxide being the only anion
- C01F17/224—Oxides or hydroxides of lanthanides
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/06—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by neutron irradiation
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- High Energy & Nuclear Physics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Geology (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Esta invención se refiere un nuevo sistema basado en nanopartículas de sesquióxido de lutecio con alta pureza y cristalinidad de acuerdo con sus planos cristalográficos obtenidos por XDR e indexados acorde a las cartas cristalográficas JCPSD No. 12-0728 (Lu2O3); de morfología cuasiesférica con tamaños de entre 20-45 nm, las cuales después de ser activadas por irradiación neutrónica (177Lu2O3) son radioluminiscentes, presentando espectros de emisión de luminiscencia en la región del infrarrojo cercano, con un máximo de emisión a ~615 nm, lo cual permite la obtención de imágenes ópticas in vivo de su biodistribución. Después de su funcionalización con un péptido inhibidor del antígeno prostático específico de membrana (PSMA), las nanopartículas de sesquióxido de lutecio aumentan sus tamaños a un intervalo de 30-50 nm, presentando bandas de vibración correspondientes a sus grupos funcionales por espectroscopia FT-IR, mismas que se replicaron en las bandas de absorción de los espectros UV-Vis observadas. Además, los valores de potencial zeta en todos los sistemas mantiene un valor absoluto mayor a los 25 mV, lo que implica alta estabilidad del sistema coloidal. El objeto de esta invención es proporcionar un nuevo nanosistema específico (radiofármaco de blancos moleculares) con potencial aplicación en nanomedicina como un agente de imagen dual (óptica y nuclear) in vivo y en la radioterapia de blancos moleculares específicos.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2021005088A MX419987B (es) | 2021-04-30 | 2021-04-30 | Nanoparticulas radioluminiscentes de sesquioxido de lutecio-177 funcionalizadas con peptidos para imagen optica. |
| PCT/MX2021/050056 WO2022231411A1 (es) | 2021-04-30 | 2021-10-15 | Nanopartículas radioluminiscentes de sesquióxido de lutecio-177 funcionalizadas con péptidos para imagen óptica |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2021005088A MX419987B (es) | 2021-04-30 | 2021-04-30 | Nanoparticulas radioluminiscentes de sesquioxido de lutecio-177 funcionalizadas con peptidos para imagen optica. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2021005088A MX2021005088A (es) | 2022-11-01 |
| MX419987B true MX419987B (es) | 2025-01-14 |
Family
ID=83847160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021005088A MX419987B (es) | 2021-04-30 | 2021-04-30 | Nanoparticulas radioluminiscentes de sesquioxido de lutecio-177 funcionalizadas con peptidos para imagen optica. |
Country Status (2)
| Country | Link |
|---|---|
| MX (1) | MX419987B (es) |
| WO (1) | WO2022231411A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11130675B2 (en) * | 2011-09-02 | 2021-09-28 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Flame spray synthesis of nanoparticles of monoclinic Lu203 and dopant |
| WO2014040222A1 (zh) * | 2012-09-11 | 2014-03-20 | 海洋王照明科技股份有限公司 | 氧化镥发光材料及其制备方法 |
| MX380340B (es) * | 2018-03-14 | 2025-03-11 | Instituto Nac De Investigaciones Nucleares | 177lu-dota-hynic-ipsma como un radiofarmaco terapeutico dirigido al antigeno prostatico especifico de membrana. |
-
2021
- 2021-04-30 MX MX2021005088A patent/MX419987B/es unknown
- 2021-10-15 WO PCT/MX2021/050056 patent/WO2022231411A1/es not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022231411A1 (es) | 2022-11-03 |
| MX2021005088A (es) | 2022-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tejwan et al. | Metal-doped and hybrid carbon dots: a comprehensive review on their synthesis and biomedical applications | |
| EP3086802B1 (en) | Cd44 binding peptides | |
| GB2573406A (en) | Tumor infiltrating lymphocytes and methods of therapy | |
| WO2015156870A3 (en) | Biopolymer-mediated assembly of nanoparticles using genetically encoded proteins | |
| BR112023017947A2 (pt) | Método de produção de um coprecipitado | |
| CR20220530A (es) | CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DÍMERO DEL RECEPTOR DE INTERLEUCINA 2 ß¿c Y CONJUGADOS CON UN POLÍMERO HIDROSOLUBLE NO PEPTÍDICO. | |
| PH12020550432A1 (en) | Compositions of phosphorylated tau peptides and uses thereof | |
| MX2020000413A (es) | Una vacuna universal basada en neoantigenos de tumor compartidos para prevencion y tratamiento de canceres inestables de microsatelite (msi). | |
| He et al. | Water-ultrastable perovskite CsPbBr3 nanocrystals for fluorescence-enhanced cellular imaging: C.-L. He et al. | |
| MX2015006374A (es) | Anticuerpos anti-ceacam5 y usos de los mismos. | |
| TW200726774A (en) | Composition and method for producing stable amyloid beta oligomers | |
| MX419987B (es) | Nanoparticulas radioluminiscentes de sesquioxido de lutecio-177 funcionalizadas con peptidos para imagen optica. | |
| EP4549478A4 (en) | Core-bark type fluorine-based resin particles with improved flowability and flocculation, and method of preparation | |
| NZ769187A (en) | Pharmaceutical composition, preparation and uses thereof | |
| BR112019004499A2 (pt) | implante compreendendo um pó compósito contendo sal de cálcio tendo partículas microestruturadas | |
| MX2018016279A (es) | Compuestos para formacion de imagenes de agregados de proteinas tau. | |
| PH12020550149A1 (en) | Crystal | |
| WO2018132371A3 (en) | Methods and compositions for treating pulmonary hypertension | |
| RU2013124525A (ru) | Способ получения частиц инкапсулированного жирорастворимой полимерной оболочкой унаби, обладающего супрамолекулярными свойствами | |
| BR112015029021A2 (pt) | gel polimérico compacto e fibras feitas do mesmo | |
| BR112021006643A8 (pt) | Composições e métodos para aumentar capacidade de distribuição sistêmica, tolerância e eficácia de peptídeos macrocíclicos catiônicos | |
| Murugan et al. | Correction: Corrigendum: Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy | |
| PE20241806A1 (es) | PRODUCCION DE 177Lu A PARTIR DE OBJETIVOS Yb | |
| BRPI0707247B8 (pt) | vacina para tumor compreendendo células tumorais alogênicas ou xenogênicas | |
| WO2024249501A3 (en) | B7h3 miniprotein conjugates |