MX9200802A - IMPROVED AND INTERMEDIARY PROCEDURES FOR CERTAIN BIS-AZA-BI-CYCLICAL ANXIOLYTIC AGENTS. - Google Patents

IMPROVED AND INTERMEDIARY PROCEDURES FOR CERTAIN BIS-AZA-BI-CYCLICAL ANXIOLYTIC AGENTS.

Info

Publication number
MX9200802A
MX9200802A MX9200802A MX9200802A MX9200802A MX 9200802 A MX9200802 A MX 9200802A MX 9200802 A MX9200802 A MX 9200802A MX 9200802 A MX9200802 A MX 9200802A MX 9200802 A MX9200802 A MX 9200802A
Authority
MX
Mexico
Prior art keywords
aza
cyclical
improved
certain bis
phthalimido
Prior art date
Application number
MX9200802A
Other languages
Spanish (es)
Inventor
Dennis Michael Godek
Charles William Murtiashaw
Frank John Urban
Brian Clement Vanderplas
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9200802A publication Critical patent/MX9200802A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Reinforced Plastic Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(C1-C3)Alkyl-4,6,7,8,9,9a-hexahydro-2H,3H-pyrido-[1,2-a]pyrazin-1-one- 7-carboxylate esters, important precursors to certain bis-aza-bicyclic anxiolytics, can be prepared from di(C1-C3)alkyl cis-piperidine-2,5-dicarboxylate starting material by a new process via a new class of intermediates, di(C1-C3)alkyl cis-N-(2-(phthalimido)ethyl)piperidine-2,5-dicarboxylates. In the process, the starting material is reacted with either 2-(phthalimido)ethyl triflate or 2-(phthalimido)acetaldehyde to form the new intermediate, which can then be cyclized to the aforementioned precursor.
MX9200802A 1991-02-27 1992-02-25 IMPROVED AND INTERMEDIARY PROCEDURES FOR CERTAIN BIS-AZA-BI-CYCLICAL ANXIOLYTIC AGENTS. MX9200802A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/661,730 US5185449A (en) 1991-02-27 1991-02-27 Process and intermediate for certain bis-aza-bicyclic anxiolytic agents

Publications (1)

Publication Number Publication Date
MX9200802A true MX9200802A (en) 1992-08-01

Family

ID=24654869

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9200802A MX9200802A (en) 1991-02-27 1992-02-25 IMPROVED AND INTERMEDIARY PROCEDURES FOR CERTAIN BIS-AZA-BI-CYCLICAL ANXIOLYTIC AGENTS.

Country Status (23)

Country Link
US (1) US5185449A (en)
EP (1) EP0586376B1 (en)
JP (1) JPH0784467B2 (en)
KR (1) KR100189044B1 (en)
AT (1) ATE153662T1 (en)
AU (1) AU647562B2 (en)
CA (1) CA2101433C (en)
DE (1) DE69126326T2 (en)
DK (1) DK0586376T3 (en)
ES (1) ES2101831T3 (en)
FI (1) FI107153B (en)
GR (1) GR3024125T3 (en)
HU (2) HUT67440A (en)
IE (1) IE920600A1 (en)
IL (1) IL101022A (en)
MX (1) MX9200802A (en)
MY (1) MY110167A (en)
NO (1) NO302947B1 (en)
NZ (1) NZ241738A (en)
PT (1) PT100161B (en)
TW (1) TW268949B (en)
WO (1) WO1992015575A1 (en)
ZA (1) ZA921406B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69218414T2 (en) * 1991-02-27 1998-01-22 Pfizer METHOD FOR PRODUCING TRANS-PIPERIDINE-2,5-DICARBOXYLATE
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
DK0783503T3 (en) * 1994-09-30 2002-02-11 Pfizer 2,7-substituted octahydro-1H-pyrido (1,2-a) pyrazine derivatives
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
DE69218414T2 (en) * 1991-02-27 1998-01-22 Pfizer METHOD FOR PRODUCING TRANS-PIPERIDINE-2,5-DICARBOXYLATE

Also Published As

Publication number Publication date
CA2101433C (en) 1999-07-27
HU223138B1 (en) 2004-03-29
FI933754L (en) 1993-08-26
ZA921406B (en) 1993-08-26
IE920600A1 (en) 1992-09-09
WO1992015575A1 (en) 1992-09-17
FI107153B (en) 2001-06-15
US5185449A (en) 1993-02-09
DE69126326T2 (en) 1997-09-04
GR3024125T3 (en) 1997-10-31
TW268949B (en) 1996-01-21
IL101022A (en) 1996-06-18
JPH0784467B2 (en) 1995-09-13
JPH06501021A (en) 1994-01-27
PT100161B (en) 1999-09-30
MY110167A (en) 1998-02-28
FI933754A0 (en) 1993-08-26
NO933048D0 (en) 1993-08-26
NO933048L (en) 1993-08-26
DK0586376T3 (en) 1997-10-27
ES2101831T3 (en) 1997-07-16
NO302947B1 (en) 1998-05-11
KR100189044B1 (en) 1999-06-01
HUT67440A (en) 1995-04-28
NZ241738A (en) 1993-05-26
AU647562B2 (en) 1994-03-24
DE69126326D1 (en) 1997-07-03
ATE153662T1 (en) 1997-06-15
IL101022A0 (en) 1992-11-15
PT100161A (en) 1993-05-31
EP0586376B1 (en) 1997-05-28
AU9066691A (en) 1992-10-06
HU9302428D0 (en) 1993-11-29
CA2101433A1 (en) 1992-08-28
EP0586376A1 (en) 1994-03-16

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees