MX9207101A - VITAMIN D DERIVATIVES REPLACED WITH METHYL IN POSITION 20 - Google Patents

VITAMIN D DERIVATIVES REPLACED WITH METHYL IN POSITION 20

Info

Publication number
MX9207101A
MX9207101A MX9207101A MX9207101A MX9207101A MX 9207101 A MX9207101 A MX 9207101A MX 9207101 A MX9207101 A MX 9207101A MX 9207101 A MX9207101 A MX 9207101A MX 9207101 A MX9207101 A MX 9207101A
Authority
MX
Mexico
Prior art keywords
vitamin
methyl
derivatives replaced
derivatives
preparation
Prior art date
Application number
MX9207101A
Other languages
Spanish (es)
Inventor
Gunter Neef
Andreas Steinmeyer
Gerald Kirsch
Katica Schwarz
Ruth Thieroffekerdt
Herbert Wiesinger
Martin Haberey
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MX9207101A publication Critical patent/MX9207101A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen los nuevos derivados de vitamina D sustituidos con metilo en posición 20, y un procedimiento para su preparación. Los nuevos compuestos tienen frente al calcitriol una inducción muy mejorada de la diferenciación celular (HL-60) y son apropiados para la preparación de medicamentos.Novel 20-methyl substituted vitamin D derivatives are described, and a procedure for their preparation. The new compounds have a much improved induction of cell differentiation against calcitriol (HL-60) and are suitable for the preparation of drugs.

MX9207101A 1991-12-13 1992-12-08 VITAMIN D DERIVATIVES REPLACED WITH METHYL IN POSITION 20 MX9207101A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4141746A DE4141746A1 (en) 1991-12-13 1991-12-13 20-METHYL-SUBSTITUTED VITAMIN D DERIVATIVES

Publications (1)

Publication Number Publication Date
MX9207101A true MX9207101A (en) 1993-08-01

Family

ID=6447341

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9207101A MX9207101A (en) 1991-12-13 1992-12-08 VITAMIN D DERIVATIVES REPLACED WITH METHYL IN POSITION 20

Country Status (24)

Country Link
US (1) US5446035A (en)
EP (1) EP0637299B1 (en)
JP (1) JP3280975B2 (en)
KR (1) KR100271462B1 (en)
CN (1) CN1035177C (en)
AT (1) ATE138366T1 (en)
AU (1) AU670585B2 (en)
CA (1) CA2125476C (en)
CZ (1) CZ286579B6 (en)
DE (2) DE4141746A1 (en)
DK (1) DK0637299T3 (en)
ES (1) ES2089585T3 (en)
FI (1) FI108226B (en)
GR (1) GR3020097T3 (en)
HU (1) HUT68263A (en)
IL (1) IL104074A (en)
MX (1) MX9207101A (en)
NO (1) NO305949B1 (en)
NZ (1) NZ246052A (en)
PL (1) PL171403B1 (en)
SK (1) SK280450B6 (en)
TW (1) TW275060B (en)
WO (1) WO1993012081A1 (en)
ZA (1) ZA929650B (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4220757A1 (en) * 1992-06-24 1994-01-05 Schering Ag Derivatives in the vitamin D series with modifications in the 20-position, process for their preparation, intermediates for this process, pharmaceutical preparations containing these derivatives and their use in the manufacture of medicaments
GB9220272D0 (en) * 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9315253D0 (en) * 1993-07-23 1993-09-08 Res Inst Medicine Chem Chemical compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5981597A (en) * 1995-02-13 1999-11-09 Trustees Of The University Of Pennsylvania Differentiating agents for the treatment of inflammatory intestinal diseases
ATE296114T1 (en) * 1996-02-13 2005-06-15 Searle & Co PREPARATIONS CONTAINING A CYCLOOXYGENASE-2 INHIBITOR AND A LEUCOTRIEN B4 RECEPTOR ANTAGONIST
DE19619036A1 (en) 1996-04-30 1997-11-13 Schering Ag New vitamin D derivatives with carbo- or heterocyclic substituents at C-25, process for their preparation and their use in the manufacture of medicinal products
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) * 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
ES2368824T3 (en) 1998-03-27 2011-11-22 Oregon Health & Science University VITAMIN D AND ITS ANALOGS IN THE TREATMENT OF TUMORS AND OTHER HYPERPROLIFERATIVE DISORDERS.
US6443856B1 (en) 1999-11-01 2002-09-03 Callaway Golf Company Contoured scorelines for the face of a golf club
US20030188756A1 (en) * 2002-08-19 2003-10-09 Cantorna Margherita T Treatment of inflammatory bowel disease with vitamin d compounds
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
WO2006120681A2 (en) * 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for skin care
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20030220307A1 (en) * 2000-08-17 2003-11-27 Akira Kawase Remedial agent for osteoporosis
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
WO2005012294A1 (en) * 2003-07-30 2005-02-10 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
US9173835B2 (en) 2005-05-10 2015-11-03 Dermipsor Ltd. Compositions and methods for treating hyperproliferative epidermal diseases
JP2008543855A (en) 2005-06-13 2008-12-04 ライジェル ファーマシューティカルズ， インコーポレイテッド Methods and compositions for treating degenerative bone disease
ATE352714T1 (en) * 2005-06-17 2007-02-15 Magneti Marelli Powertrain Spa FUEL INJECTION VALVE
DE602007012216D1 (en) * 2006-04-10 2011-03-10 Wisconsin Alumni Res Found 1-ALPHA-HYDROXY-2- (3'-HYDROXYPROPYLIDES) -19-NOR-VITAMIN-D COMPOUNDS WITH A 1,1-DIMETHYLPROPYL SIDE CHAIN
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
EP2425874A3 (en) 2006-08-25 2013-05-15 Cougar Biotechnology, Inc. Use of a vitamin D compound and an additional therapeutic agent for the treatment of cancer
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US20090124587A1 (en) * 2007-07-12 2009-05-14 Auerbach Alan H METHODS FOR TREATING CANCER USING 17alpha-HYDROXYLASE/C17,20-LYASE INHIBITORS
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (en) 2009-08-14 2021-05-07 博格有限责任公司 Vitamin D3 and analogs thereof for the treatment of alopecia
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury
UA124972C2 (en) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Methods of treating prostate cancer
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
US11903952B2 (en) 2020-05-27 2024-02-20 Northwestern University Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection

Also Published As

Publication number Publication date
ZA929650B (en) 1993-06-09
NO305949B1 (en) 1999-08-23
CZ286579B6 (en) 2000-05-17
FI108226B (en) 2001-12-14
KR100271462B1 (en) 2000-11-15
EP0637299A1 (en) 1995-02-08
WO1993012081A1 (en) 1993-06-24
GR3020097T3 (en) 1996-08-31
CA2125476C (en) 2003-02-11
DK0637299T3 (en) 1996-09-30
IL104074A (en) 1998-01-04
SK280450B6 (en) 2000-02-14
DE59206393D1 (en) 1996-06-27
TW275060B (en) 1996-05-01
ES2089585T3 (en) 1996-10-01
CA2125476A1 (en) 1993-06-24
CN1035177C (en) 1997-06-18
NZ246052A (en) 1995-07-26
JP3280975B2 (en) 2002-05-13
NO942178D0 (en) 1994-06-10
IL104074A0 (en) 1993-05-13
SK66194A3 (en) 1995-02-08
JPH07505132A (en) 1995-06-08
AU4035693A (en) 1993-07-19
FI942766A7 (en) 1994-06-10
US5446035A (en) 1995-08-29
DE4141746A1 (en) 1993-06-17
EP0637299B1 (en) 1996-05-22
CZ141694A3 (en) 1995-01-18
PL171403B1 (en) 1997-04-30
HU9401456D0 (en) 1994-08-29
NO942178L (en) 1994-06-10
KR940703806A (en) 1994-12-12
AU670585B2 (en) 1996-07-25
CN1073677A (en) 1993-06-30
HUT68263A (en) 1995-06-28
ATE138366T1 (en) 1996-06-15
FI942766A0 (en) 1994-06-10

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees