MY100148A - Process for preparing 1 , 5 - benzothiazepine derivatives - Google Patents
Process for preparing 1 , 5 - benzothiazepine derivativesInfo
- Publication number
- MY100148A MY100148A MYPI88000710A MYPI19880710A MY100148A MY 100148 A MY100148 A MY 100148A MY PI88000710 A MYPI88000710 A MY PI88000710A MY PI19880710 A MYPI19880710 A MY PI19880710A MY 100148 A MY100148 A MY 100148A
- Authority
- MY
- Malaysia
- Prior art keywords
- formula
- compound
- benzothiazepine derivatives
- preparing
- lower alkyl
- Prior art date
Links
- KJFRSZASZNLCDF-UHFFFAOYSA-N 1,5-benzothiazepine Chemical class S1C=CC=NC2=CC=CC=C12 KJFRSZASZNLCDF-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 ALKALI METAL SALT Chemical class 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 239000003218 coronary vasodilator agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A 1,5-BENZOTHIAZEPINE DERIVATIVES OF THE FORMULA : WHERE AR IS PHCNYL SUBSTITUTED WITH A LOWER ALKOXY, R IS A LOWER ALKYL, R1 AND R ARE EACH A LOWER ALKYL, AND Y IS A LOWER ALKYLENE IS PREPARED BY REACTING A 1,5- BENZOTHIAZEPIN DERATIVES OF THE FORMULA (II), PREFERABLY AN ALKALI METAL SALT THCREOF ON THE NITROGEN ATOM AT 5-POSITION, WITH A COMPOUND OF THE FORMULA (III) AS SHOWN IN THE FOLLOWING REACTION SCHEME-I.WHERE AR, R, R1, R2 AND Y ARE AS DEFINED ABOVE, AND Z IS A HALOGEN.THE COMPOUND (I) OF THE INVENTION HAS EXCELLENT CORONARY VASODILATING AND PSYCHONEUROTIC ACTIVITIES AND IS USEFUL PARTICULARLY AS A CA2+ -ANTIGONISTIC CORONARY VASODILATOR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP82106261A EP0098892B1 (en) | 1982-07-09 | 1982-07-13 | Process for preparing 1,5-benzothiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY100148A true MY100148A (en) | 1990-01-18 |
Family
ID=8189129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI88000710A MY100148A (en) | 1982-07-13 | 1988-06-27 | Process for preparing 1 , 5 - benzothiazepine derivatives |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE3277532D1 (en) |
| HK (1) | HK95588A (en) |
| MY (1) | MY100148A (en) |
-
1982
- 1982-07-13 DE DE8282106261T patent/DE3277532D1/en not_active Expired
-
1988
- 1988-06-27 MY MYPI88000710A patent/MY100148A/en unknown
- 1988-11-24 HK HK95588A patent/HK95588A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3277532D1 (en) | 1987-12-03 |
| HK95588A (en) | 1988-12-02 |
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