MY101443A - Analogs of mevalonolactone and derivatives thereof, processes of their production, pharmaceutical compositions containing them and their use as pharmaceuticals - Google Patents
Analogs of mevalonolactone and derivatives thereof, processes of their production, pharmaceutical compositions containing them and their use as pharmaceuticalsInfo
- Publication number
- MY101443A MY101443A MYPI87001949A MYPI19871949A MY101443A MY 101443 A MY101443 A MY 101443A MY PI87001949 A MYPI87001949 A MY PI87001949A MY PI19871949 A MYPI19871949 A MY PI19871949A MY 101443 A MY101443 A MY 101443A
- Authority
- MY
- Malaysia
- Prior art keywords
- mevalonolactone
- pharmaceuticals
- analogs
- hydrogen
- derivatives
- Prior art date
Links
- JYVXNLLUYHCIIH-UHFFFAOYSA-N (+/-)-mevalonolactone Natural products CC1(O)CCOC(=O)C1 JYVXNLLUYHCIIH-UHFFFAOYSA-N 0.000 title 1
- JYVXNLLUYHCIIH-ZCFIWIBFSA-N R-mevalonolactone, (-)- Chemical compound C[C@@]1(O)CCOC(=O)C1 JYVXNLLUYHCIIH-ZCFIWIBFSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940057061 mevalonolactone Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- -1 T-BUTOXY Chemical class 0.000 abstract 6
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical group O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPOUNDS OF FORMULA I ( FORMULA I ) WHEREIN ONE OF R AND R0 IS ( FORMULA 2 ) AND THE OTHER IS PRIMARY OF SECONDARY C1-6 ALKYL, C3-6 CYCLOALKYL OR PHENYL- (CH2) M-, WHEREIN R4 IS HYDROGEN, C1-4 ALKYL, C1-4 ALKOXY, (EXCEPT T-BUTOXY),TRIFLUOROMETHYL, FLUORO, CHLORO, PHENOXY OR BENZYLOXY, R5 IS HYDROGEN, C1-3 ALKYL, C1-3 ALKOXY, TRIFLUOROMETHYL, FLUORO, CHLORO, PHENOXY OR BENZYLOXY, R5A IS HYDROGEN, C1-2 ALKYL, C1-2 ALKOXY , FLUORO OR CHLORO, AND M IS 1, 2 OR 3, WITH THE- PROVISOS THAT BOTH R5 AND R5A MUST BE HYDROGEN WHEN R4 IS HYDROGEN, R5A MUST BE HYDROGEN WHEN R5 IS HYDROGEN, NOT MORE THAN ONE OF R4 AND R5 IS TRIFLUOROMETHYL, NOT MORE THAN ONE OF R4 AND R5 IS PHENOXY AND NOT MORE THAN ONE OF R4 AND R5 IS BENZYLOXY.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44366882A | 1982-11-22 | 1982-11-22 | |
| EP83810548A EP0114027B1 (en) | 1982-11-22 | 1983-11-22 | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY101443A true MY101443A (en) | 1991-11-18 |
Family
ID=23761739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI87001949A MY101443A (en) | 1982-11-22 | 1987-09-25 | Analogs of mevalonolactone and derivatives thereof, processes of their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS60500015A (en) |
| KR (1) | KR900009006B1 (en) |
| ES (1) | ES8506622A1 (en) |
| MY (1) | MY101443A (en) |
| PH (1) | PH23486A (en) |
| PT (1) | PT77694B (en) |
| ZA (1) | ZA838718B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0532737U (en) * | 1991-10-11 | 1993-04-30 | 日産自動車株式会社 | Gas turbine ceramic structure |
| ES2304140T3 (en) * | 2001-08-03 | 2008-09-16 | Ciba Holding Inc. | FLUVASTATINE SODIUM CRYSTAL FORMS. |
| WO2004094377A1 (en) * | 2003-04-24 | 2004-11-04 | Daicel Chemical Industries Ltd. | Method for separation of optically active dihydroxy- heptenoic acid esters |
| US7923573B2 (en) | 2004-10-27 | 2011-04-12 | Daiichi Sankyo Company, Limited | Benzene compound having 2 or more substituents |
| WO2008001499A1 (en) | 2006-06-29 | 2008-01-03 | Kowa Co., Ltd. | Prophylactic and/or therapeutic agent for rheumatoid arthritis |
| ES2425969T3 (en) | 2007-04-27 | 2013-10-18 | Kyushu University, National University Corporation | Agent for the treatment of lung diseases |
| US20130115622A1 (en) | 2009-12-14 | 2013-05-09 | Kyoto University | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis |
| JP6536871B2 (en) | 2013-12-02 | 2019-07-03 | 国立大学法人京都大学 | Preventive and therapeutic agent for FGFR3 disease and method of screening the same |
| JP7356968B2 (en) | 2018-05-08 | 2023-10-05 | 国立大学法人 岡山大学 | Medicines useful for cardiovascular diseases |
| WO2020130147A1 (en) | 2018-12-21 | 2020-06-25 | 国立大学法人京都大学 | Lubricin-localized cartilage-like tissue, method for producing same and composition comprising same for treating articular cartilage damage |
| SG11202109928WA (en) | 2019-03-13 | 2021-10-28 | National Univ Corporation Hamamatsu Univ School Of Medicine | Pharmaceutical composition for treating aortic aneurysm |
| US20230172996A1 (en) | 2020-02-21 | 2023-06-08 | Yoshikazu NAKAOKA | Composition for alleviating pulmonary hypertension, method for predicting prognosis of pulmonary hypertension, method for assisting in determining severity of pulmonary hypertension, and method for assisting in diagnosing pulmonary hypertension |
-
1983
- 1983-11-18 JP JP58503754A patent/JPS60500015A/en active Granted
- 1983-11-18 PH PH29858A patent/PH23486A/en unknown
- 1983-11-21 ES ES527428A patent/ES8506622A1/en not_active Expired
- 1983-11-21 PT PT77694A patent/PT77694B/en unknown
- 1983-11-22 KR KR1019830005533A patent/KR900009006B1/en not_active Expired
- 1983-11-22 ZA ZA838718A patent/ZA838718B/en unknown
-
1987
- 1987-09-25 MY MYPI87001949A patent/MY101443A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES527428A0 (en) | 1985-08-01 |
| PT77694B (en) | 1986-04-17 |
| ZA838718B (en) | 1985-08-28 |
| ES8506622A1 (en) | 1985-08-01 |
| KR840007221A (en) | 1984-12-06 |
| PH23486A (en) | 1989-08-16 |
| JPS60500015A (en) | 1985-01-10 |
| PT77694A (en) | 1983-12-01 |
| JPH0246031B2 (en) | 1990-10-12 |
| KR900009006B1 (en) | 1990-12-17 |
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