MY104920A - Peptide boronic acid inhibitors of trypsin-like proteases. - Google Patents
Peptide boronic acid inhibitors of trypsin-like proteases.Info
- Publication number
- MY104920A MY104920A MYPI88000593A MYPI19880593A MY104920A MY 104920 A MY104920 A MY 104920A MY PI88000593 A MYPI88000593 A MY PI88000593A MY PI19880593 A MYPI19880593 A MY PI19880593A MY 104920 A MY104920 A MY 104920A
- Authority
- MY
- Malaysia
- Prior art keywords
- trypsin
- boronic acid
- proteases
- acid inhibitors
- peptide boronic
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102100027612 Kallikrein-11 Human genes 0.000 title 1
- 101710152431 Trypsin-like protease Proteins 0.000 title 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title 1
- 239000004475 Arginine Substances 0.000 abstract 1
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 102000003827 Plasma Kallikrein Human genes 0.000 abstract 1
- 108090000113 Plasma Kallikrein Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001642 boronic acid derivatives Chemical group 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 229940012957 plasmin Drugs 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
- 230000001810 trypsinlike Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PEPTIDES COMPRISING C-TERMINAL BORONIC ACID DERIVATIVES OF LYSINE, ORNITHINE, AND ARGININE, HOMOARGININE AND CORRESPONDING ISOTHIOURONIUM ANALOGS THEREOF, ARE REVERSIBLE INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASES SUCH AS THROMBIN, PLASMA KALLIKREIN AND PLASMIN.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5957087A | 1987-06-05 | 1987-06-05 | |
| US07/178,368 US5187157A (en) | 1987-06-05 | 1988-04-06 | Peptide boronic acid inhibitors of trypsin-like proteases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY104920A true MY104920A (en) | 1994-07-30 |
Family
ID=79961358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI88000593A MY104920A (en) | 1987-06-05 | 1988-06-04 | Peptide boronic acid inhibitors of trypsin-like proteases. |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY104920A (en) |
-
1988
- 1988-06-04 MY MYPI88000593A patent/MY104920A/en unknown
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