MY106032A - New pharmaceutical compositions & new pharmaceutical products allowing the regeneration of leukocytes & their use in the treatment of acquired immuno-deficient syndrom - Google Patents
New pharmaceutical compositions & new pharmaceutical products allowing the regeneration of leukocytes & their use in the treatment of acquired immuno-deficient syndromInfo
- Publication number
- MY106032A MY106032A MYPI89001798A MYPI19891798A MY106032A MY 106032 A MY106032 A MY 106032A MY PI89001798 A MYPI89001798 A MY PI89001798A MY PI19891798 A MYPI19891798 A MY PI19891798A MY 106032 A MY106032 A MY 106032A
- Authority
- MY
- Malaysia
- Prior art keywords
- new pharmaceutical
- pharmaceutical compositions
- syndrom
- new
- leukocytes
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 208000011580 syndromic disease Diseases 0.000 title abstract 2
- 230000002950 deficient Effects 0.000 title 1
- 210000000265 leukocyte Anatomy 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 230000008929 regeneration Effects 0.000 title 1
- 238000011069 regeneration method Methods 0.000 title 1
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Natural products O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 abstract 2
- 210000004698 lymphocyte Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001172 regenerating effect Effects 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000002547 new drug Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- IQFYYKKMVGJFEH-HVNIONSBSA-N thymidine-2-14c Chemical class O=[14C]1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-HVNIONSBSA-N 0.000 abstract 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 abstract 1
- 229940045145 uridine Drugs 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
THIS INVENTION RELATES TO NOVEL PHARMACEUTICAL COMPOSITIONS TO NEW PRODUCTS AND TO METHOD FOR REGENERATING OR IMPROVING THE LEVEL OF LYMPHOCYTES T4 IN PATIENT SUFFERING FORM IMMUNO-DEFICITARY SYNDROM. THE NEW PHARMACEUTICAL COMPOSITIONS ACCORDING TO THIS INVENTION CONTAIN AS ACTIVE INGREDIENT AT LEAST ONE COMPOUND SELECTED FROM THE GROUP CONSISTING OF 9-AMINO 1,2,3,4-TETRAHYDROACRIDINE, IN THE FREE BASE FORM OR AS AN ACID ADDITION SALTS, AND ITS BIOLOGICAL PRECURSORS, IN ADMIXTURE OR CONJUNCTION WITH AN INERT NON TOXIC PHARMACEUTICALLY-ACCEPTABLE CARRIER OR VEHICLE. THIS INVENTION ALSO EXTENDS TO A METHOD FOR REGENERATING OR IMPROVING THE COUNT OF LYMPHOCYTES T4 IN PATIENTS SUFFERING FROM SAID SYMPTOMS ALONE OR IN ADDITION WITH A THERAPY WITH AN ANTIVIRAL DRUG SELECTED FROM THE GROUP CONSISTING OF DERIVATIVES OF THYMIDINE, URACILE AND URIDINE. THESE NEW DRUGS MAY BE GIVEN AS WELL TO CHILDREN AS TO ADULT MEN FOR AN EXTENDED PERIOD OF TIME WITH SIGNIFICANT EVIDENCE OF RECOVERY.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR888816749A FR2640508B1 (en) | 1988-12-19 | 1988-12-19 | NOVEL COMPOSITIONS AND NEW PHARMACEUTICAL PRODUCTS ENSURING THE REGENERATION OF LEUKOCYTES AND THEIR USE FOR THE TREATMENT OF IMMUNE DEFICIT SYNDROME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY106032A true MY106032A (en) | 1995-02-28 |
Family
ID=9373109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI89001798A MY106032A (en) | 1988-12-19 | 1989-12-18 | New pharmaceutical compositions & new pharmaceutical products allowing the regeneration of leukocytes & their use in the treatment of acquired immuno-deficient syndrom |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0375471B1 (en) |
| JP (1) | JPH02258722A (en) |
| KR (1) | KR900009075A (en) |
| AP (1) | AP125A (en) |
| AT (1) | ATE136463T1 (en) |
| AU (2) | AU4686189A (en) |
| CA (1) | CA2005925C (en) |
| DE (1) | DE68926222D1 (en) |
| DK (1) | DK646489A (en) |
| FR (1) | FR2640508B1 (en) |
| HU (1) | HU213510B (en) |
| IL (1) | IL92759A (en) |
| MA (1) | MA21964A1 (en) |
| MY (1) | MY106032A (en) |
| NZ (1) | NZ231854A (en) |
| OA (1) | OA09250A (en) |
| PT (1) | PT92620B (en) |
| TN (1) | TNSN89135A1 (en) |
| ZA (1) | ZA899733B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155226A (en) * | 1991-02-19 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Incorporated | Method for the preparation of 9-amino-1,2,3,4-tetrahydroacridine |
| EP0509401A1 (en) * | 1991-04-19 | 1992-10-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Use of 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds for the treatment of aids |
| RU2036198C1 (en) * | 1993-04-01 | 1995-05-27 | Товарищество с ограниченной ответственностью "Полисан" | N-METHYL- N- (α-D- GLUCOPYRANOSYL) -AMMONIUM -2-(ACRIDONE -9-ONE -10-YL) -ACETATE (CYCLOFERON) SHOWING INTERFEROGENIC, ANTIVIRAL AMONG THEM ANTI-HIV, ANTIPARASITIC, ANTIPROMOTER AND RADIOPROTECTIVE ACTIVITIES |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4916122A (en) * | 1987-01-28 | 1990-04-10 | University Of Georgia Research Foundation, Inc. | 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition |
| JPH02500364A (en) * | 1986-11-21 | 1990-02-08 | マツクス‐プランク‐ゲゼルシヤフト ツール フエルデルング デル ヴイツセンシヤフテン エー フアウ | Methods for treating viral infections in humans and compositions therefor |
| IL86009A (en) * | 1987-04-10 | 1991-09-16 | Us Health | Liposome-encapsulated phosphorylated nucleosides for treatment of retroviral diseases |
| US5013741A (en) * | 1987-09-08 | 1991-05-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal |
| DE3889302T2 (en) * | 1987-12-03 | 1994-10-20 | Mitsubishi Chem Ind | 9- (Acylamino) tetrahydroacridine derivatives and perceptual agents thereof as an active ingredient. |
| CH678275A5 (en) * | 1989-05-25 | 1991-08-30 | Debiopharm Sa | |
| US4999358A (en) * | 1989-06-26 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds |
| US4999430A (en) * | 1989-07-31 | 1991-03-12 | Warner-Lambert Company | Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine |
-
1988
- 1988-12-19 FR FR888816749A patent/FR2640508B1/en not_active Expired - Fee Related
-
1989
- 1989-09-29 EP EP89402687A patent/EP0375471B1/en not_active Expired - Lifetime
- 1989-09-29 DE DE68926222T patent/DE68926222D1/en not_active Expired - Lifetime
- 1989-09-29 AT AT89402687T patent/ATE136463T1/en not_active IP Right Cessation
- 1989-12-18 MY MYPI89001798A patent/MY106032A/en unknown
- 1989-12-18 IL IL9275989A patent/IL92759A/en not_active IP Right Cessation
- 1989-12-18 AP APAP/P/1990/000157A patent/AP125A/en active
- 1989-12-18 MA MA21958A patent/MA21964A1/en unknown
- 1989-12-19 DK DK646489A patent/DK646489A/en not_active Application Discontinuation
- 1989-12-19 PT PT92620A patent/PT92620B/en not_active IP Right Cessation
- 1989-12-19 AU AU46861/89A patent/AU4686189A/en not_active Abandoned
- 1989-12-19 ZA ZA899733A patent/ZA899733B/en unknown
- 1989-12-19 NZ NZ231854A patent/NZ231854A/en unknown
- 1989-12-19 KR KR1019890019125A patent/KR900009075A/en not_active Ceased
- 1989-12-19 JP JP1329377A patent/JPH02258722A/en active Pending
- 1989-12-19 OA OA59701A patent/OA09250A/en unknown
- 1989-12-19 HU HU896683A patent/HU213510B/en not_active IP Right Cessation
- 1989-12-19 CA CA002005925A patent/CA2005925C/en not_active Expired - Fee Related
- 1989-12-19 TN TNTNSN89135A patent/TNSN89135A1/en unknown
-
1993
- 1993-05-25 AU AU39806/93A patent/AU666725B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT92620A (en) | 1990-06-29 |
| DE68926222D1 (en) | 1996-05-15 |
| AP125A (en) | 1991-03-19 |
| JPH02258722A (en) | 1990-10-19 |
| EP0375471A2 (en) | 1990-06-27 |
| NZ231854A (en) | 1993-01-27 |
| IL92759A0 (en) | 1990-09-17 |
| TNSN89135A1 (en) | 1991-02-04 |
| AU3980693A (en) | 1993-08-19 |
| AU666725B2 (en) | 1996-02-22 |
| EP0375471A3 (en) | 1992-07-08 |
| HU896683D0 (en) | 1990-02-28 |
| CA2005925C (en) | 2002-03-26 |
| MA21964A1 (en) | 1991-07-01 |
| CA2005925A1 (en) | 1990-06-19 |
| FR2640508A1 (en) | 1990-06-22 |
| KR900009075A (en) | 1990-07-02 |
| ZA899733B (en) | 1991-04-24 |
| ATE136463T1 (en) | 1996-04-15 |
| IL92759A (en) | 1994-06-24 |
| DK646489D0 (en) | 1989-12-19 |
| EP0375471B1 (en) | 1996-04-10 |
| FR2640508B1 (en) | 1994-07-01 |
| HU213510B (en) | 1997-07-28 |
| DK646489A (en) | 1990-06-20 |
| AU4686189A (en) | 1990-06-21 |
| OA09250A (en) | 1992-06-30 |
| PT92620B (en) | 1995-09-12 |
| AP8900157A0 (en) | 1990-01-31 |
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