MY106120A - Peptide derivatives. - Google Patents

Peptide derivatives.

Info

Publication number
MY106120A
MY106120A MYPI89001655A MYPI19891655A MY106120A MY 106120 A MY106120 A MY 106120A MY PI89001655 A MYPI89001655 A MY PI89001655A MY PI19891655 A MYPI19891655 A MY PI19891655A MY 106120 A MY106120 A MY 106120A
Authority
MY
Malaysia
Prior art keywords
somatostatin
peptide derivatives
detectable element
amino group
group
Prior art date
Application number
MYPI89001655A
Inventor
Dr Steven W J Lamberts Prof
Janos Pless dr
Eric P Krenning Dr
Rainer Albert Dr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MY106120A publication Critical patent/MY106120A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SOMATOSTATIN PEPTIDES BEARING AT LEAST ONE CHELATING GROUP FOR A DETECTABLE ELEMENT, SAID CHELATING GROUP BEING LINKED TO AN AMINO GROUP OF SAID PEPTIDE, AND SAID AMINO GROUP HAVING NO SIGNIFICANT BINDING AFFINITY FOR SOMATOSTATIN RECEPTORS, IN FREE OR SALT FORM, ARE COMPLEXED WITH A DETECTABLE ELEMENT AND AS SUCH ARE USEFUL AS A PHARMACEUTICAL, E.G. A RADIOPHARMACEUTICAL FOR IN VIVO IMAGING OF SOMATOSTATIN RECEPTOR POSITIVE TUMORS OR FOR THERAPY.
MYPI89001655A 1988-12-05 1989-11-29 Peptide derivatives. MY106120A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
MY106120A true MY106120A (en) 1995-03-31

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI89001655A MY106120A (en) 1988-12-05 1989-11-29 Peptide derivatives.

Country Status (24)

Country Link
JP (2) JP2726320B2 (en)
KR (1) KR0156541B1 (en)
AT (1) AT403476B (en)
AU (1) AU633859B2 (en)
BE (1) BE1002296A5 (en)
CA (1) CA2004532C (en)
CH (1) CH678329A5 (en)
DE (1) DE3991505B4 (en)
DK (1) DK175338B1 (en)
ES (1) ES2023533A6 (en)
FI (1) FI102540B1 (en)
FR (1) FR2639947B1 (en)
GB (1) GB2225579B (en)
HK (1) HK189995A (en)
HU (2) HUT53375A (en)
IE (1) IE62091B1 (en)
IL (1) IL92534A (en)
LU (1) LU87633A1 (en)
MY (1) MY106120A (en)
NL (1) NL194828C (en)
PT (1) PT92487B (en)
SA (1) SA96160495B1 (en)
SE (1) SE508799C2 (en)
WO (1) WO1990006949A2 (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3822557C2 (en) * 1987-07-10 1998-07-02 Ciba Geigy Ag Medicines containing somatostatins
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
ATE181240T1 (en) * 1991-02-08 1999-07-15 Biomeasure Inc USE OF SOMATOSTATIN ANALOGUE FOR THE TREATMENT OF MELANOMA
AU657770B2 (en) * 1991-06-03 1995-03-23 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
ES2150916T3 (en) * 1991-08-29 2000-12-16 Mallinckrodt Medical Inc USE OF GENISTIC ACID OR GENTISILIC ALCOHOL TO STABILIZE RADIO-MARKED PEPTIDES AND PROTEINS.
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
EP0629133B1 (en) * 1992-01-03 2000-11-29 Rhomed, Incorporated Peptide-metal ion pharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
WO1995000553A1 (en) * 1993-06-23 1995-01-05 Diatech, Inc. Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
JPH08504166A (en) * 1992-02-05 1996-05-07 マリンクロッド・メディカル・インコーポレイテッド Radiolabeled peptide compound
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
CA2131315A1 (en) * 1992-03-25 1993-09-30 Geert J. Ensing Method of intraoperatively detecting and locating tumoral tissues
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
EP0607103A3 (en) * 1993-01-12 1997-07-09 Sandoz Ltd Somatostatin analogs containing chelating agents and their radio-labeled compositions.
CA2154667A1 (en) * 1993-02-02 1994-08-18 Linda M. Gustavson Directed biodistribution of small molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181L (en) 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalcohol-peptide derivatives
DE19917713A1 (en) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Short-chain peptide-dye conjugates as contrast agents for optical diagnostics
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
JP5398945B2 (en) 2001-04-23 2014-01-29 マリンクロッド エルエルシー Tc and Re labeled radioactive glycosylated octreotide derivatives
CN100475271C (en) 2003-08-20 2009-04-08 加利福尼亚大学董事会 Somatostatin analogs with inhibitory activity to growth hormone release
KR20110119813A (en) * 2003-09-17 2011-11-02 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 Mechanism-based Targeted Pancreatic Beta Cell Imaging and Therapy
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
EP2922578B1 (en) 2012-11-21 2018-12-12 Serene, Llc Tin-117m comprising somatostatin receptor binding compounds
CN119708199A (en) 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 Somatostatin peptide analogue, chelate and application thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3511206A1 (en) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Polypeptide derivatives, their preparation and pharmaceutical products which contain these polypeptide derivatives
DE3522638A1 (en) * 1985-06-25 1987-01-08 Diamalt Ag NEW SOMATOSTATIN DERIVATIVES
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
CA1266344A (en) * 1986-02-14 1990-02-27 Miki Kurami High molecular compounds having amino groups, and their utilization
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
CH679045A5 (en) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
BE1003762A3 (en) * 1988-11-11 1992-06-09 Sandoz Sa New therapeutic use somatostatin and analogues and derivatives.

Also Published As

Publication number Publication date
PT92487A (en) 1990-06-29
GB2225579B (en) 1993-03-17
HU896359D0 (en) 1990-02-28
SA96160495B1 (en) 2006-08-23
NL8902981A (en) 1990-07-02
FI895809A0 (en) 1989-12-04
IE893866L (en) 1990-06-05
SE508799C2 (en) 1998-11-09
NL194828C (en) 2003-04-03
HUT53375A (en) 1990-10-28
HU211468A9 (en) 1995-11-28
KR0156541B1 (en) 1998-10-15
SE8904087D0 (en) 1989-12-04
DE3991505B4 (en) 2006-04-20
FR2639947B1 (en) 1995-04-21
FI102540B (en) 1998-12-31
IE62091B1 (en) 1994-12-14
ATA901789A (en) 1997-07-15
FR2639947A1 (en) 1990-06-08
WO1990006949A3 (en) 1990-07-26
SE8904087L (en) 1991-06-05
FI102540B1 (en) 1998-12-31
DK612689D0 (en) 1989-12-05
PT92487B (en) 1996-01-31
LU87633A1 (en) 1991-09-18
HK189995A (en) 1995-12-29
WO1990006949A2 (en) 1990-06-28
IL92534A (en) 1994-06-24
GB2225579A (en) 1990-06-06
JPH1095737A (en) 1998-04-14
AU633859B2 (en) 1993-02-11
JP2726320B2 (en) 1998-03-11
JPH02184698A (en) 1990-07-19
JP3686503B2 (en) 2005-08-24
DK175338B1 (en) 2004-08-30
BE1002296A5 (en) 1990-11-20
ES2023533A6 (en) 1992-01-16
AT403476B (en) 1998-02-25
CA2004532C (en) 2000-02-22
GB8927255D0 (en) 1990-01-31
AU4587189A (en) 1990-06-14
NL194828B (en) 2002-12-02
CA2004532A1 (en) 1990-06-05
CH678329A5 (en) 1991-08-30
KR900009697A (en) 1990-07-05
DK612689A (en) 1990-06-06

Similar Documents

Publication Publication Date Title
WO1990006949A3 (en) Peptide derivatives
IL95118A0 (en) Polypeptide derivatives,their preparation and pharmaceutical compositions containing them
Wilkinson Troponin C from rabbit slow skeletal and cardiac muscle is the product of a single gene
US5225180A (en) Technetium-99m labeled somatostatin-derived peptides for imaging
US5814298A (en) Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
ZA954547B (en) Technetium-99m labeled peptides for imaging
GR3026658T3 (en) Hydrazino-type radionuclide chelators having an n 3?s configuration
Elzinga et al. The primary structure of actin from rabbit skeletal muscle. Five cyanogen bromide peptides, including the NH2 and COOH termini.
DE69326335D1 (en) Technetium-99M labeled peptides for imaging
DE69635080D1 (en) RADIOMETALL-BINDING ANALOGS FROM LHRH
EP0877760A4 (en)
GB9108652D0 (en) Immunoreactive compounds
ATE380038T1 (en) RADIOMETALL-BINDING PEPTIDE ANALOGUE
EP0332225A3 (en) Antibody to polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor
EP1270585A4 (en) Peptide derivative
AU7528894A (en) Hydrazino-type n2s2 chelators
DE69434384D1 (en) METALKOMPLEXBILDNER
BG103872A (en) Glycoconjugates of 20(s)-camptotecin
CA2069638A1 (en) Mri image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
GR1002475B (en) Method for preparing peptidic derivatives
EP0264953A3 (en) Amino acid preparations containing n,n'-bis-l-amino acid-l-cystin peptides for oral and parenteral use
AU3602695A (en) Novel n3s2 chelating ligands optionally radiolabelled with tc or re, useful for diagnostic or therapeutic applications
Kikuchi et al. Effect of insulin fragments on biological activity of insulin and desoctapeptide insulin. I. Potentiation of biological activities.
FI943306L (en) Method for preparing a ligand complexed with a pharmaceutically usable radionuclide
ES2009274A6 (en) Synthesis of glyco-enkephalin derivs. of hyp5