MY106261A - Anti-inflammatory 1-heteroaryl oxindole-3-carboxamides. - Google Patents

Anti-inflammatory 1-heteroaryl oxindole-3-carboxamides.

Info

Publication number
MY106261A
MY106261A MYPI90000022A MYPI19900022A MY106261A MY 106261 A MY106261 A MY 106261A MY PI90000022 A MYPI90000022 A MY PI90000022A MY PI19900022 A MYPI19900022 A MY PI19900022A MY 106261 A MY106261 A MY 106261A
Authority
MY
Malaysia
Prior art keywords
oxindole
carboxamides
heteroaryl
inflammatory
phenyl
Prior art date
Application number
MYPI90000022A
Inventor
George Lombardino Joseph
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MY106261A publication Critical patent/MY106261A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

CERTAIN N-(SUBSTITUTED)-1-HETEROARYL-OXINDOLE-3-CARBOXAMIDES WHEREIN THE N-SUBSTITUENT IS THIENYL, FURYL, PHENYL OR SUBSTITUTED PHENYL, ARE INHIBITORS OF CYCLOXYGENASE AND LIPOXYGENASE ENZYMES AND ARE USEFUL AS ANTI-INFLAMMATORY AGENTS IN MAMMALS.
MYPI90000022A 1989-01-10 1990-01-08 Anti-inflammatory 1-heteroaryl oxindole-3-carboxamides. MY106261A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000080 WO1990008146A1 (en) 1989-01-10 1989-01-10 Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides

Publications (1)

Publication Number Publication Date
MY106261A true MY106261A (en) 1995-04-29

Family

ID=22214773

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI90000022A MY106261A (en) 1989-01-10 1990-01-08 Anti-inflammatory 1-heteroaryl oxindole-3-carboxamides.

Country Status (20)

Country Link
US (1) US5128352A (en)
EP (1) EP0378357B1 (en)
JP (1) JPH0678337B2 (en)
KR (1) KR920006784B1 (en)
AT (1) ATE100096T1 (en)
AU (1) AU616090B2 (en)
CA (1) CA2007651C (en)
DE (1) DE69005833T2 (en)
DK (1) DK0378357T3 (en)
ES (1) ES2062318T3 (en)
FI (1) FI94247C (en)
HU (1) HU217072B (en)
IE (1) IE61796B1 (en)
IL (1) IL92961A0 (en)
MY (1) MY106261A (en)
NO (1) NO178193C (en)
NZ (1) NZ232038A (en)
PT (1) PT92801B (en)
WO (1) WO1990008146A1 (en)
ZA (1) ZA90140B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE301457T1 (en) * 1995-06-12 2005-08-15 Searle & Co AGENT CONTAINING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR
CA2978823C (en) 2014-12-29 2023-10-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Small molecule inhibitors of lactate dehydrogenase and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4176191A (en) * 1977-09-06 1979-11-27 Abbott Laboratories Aminomethylene oxindoles
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
ATE63543T1 (en) * 1984-02-07 1991-06-15 Pfizer 2-OXINDOLE INTERMEDIATE.
HU203238B (en) * 1984-08-24 1991-06-28 Pfizer Process for producing antiinflammatory tricyclic oxindole derivatives
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents
US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
US4791129A (en) * 1987-01-20 1988-12-13 Pfizer Inc. 1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents

Also Published As

Publication number Publication date
CA2007651C (en) 1997-08-19
ATE100096T1 (en) 1994-01-15
PT92801B (en) 1995-12-29
IE900074L (en) 1990-07-10
DK0378357T3 (en) 1994-02-14
ZA90140B (en) 1991-08-28
AU4781790A (en) 1990-07-19
CA2007651A1 (en) 1991-07-12
JPH02247174A (en) 1990-10-02
AU616090B2 (en) 1991-10-17
IE61796B1 (en) 1994-11-30
HUT58084A (en) 1992-01-28
DE69005833T2 (en) 1994-04-28
PT92801A (en) 1990-07-31
US5128352A (en) 1992-07-07
NZ232038A (en) 1991-06-25
EP0378357A1 (en) 1990-07-18
HU217072B (en) 1999-11-29
DE69005833D1 (en) 1994-02-24
EP0378357B1 (en) 1994-01-12
FI94247B (en) 1995-04-28
NO178193B (en) 1995-10-30
KR920006784B1 (en) 1992-08-17
ES2062318T3 (en) 1994-12-16
FI94247C (en) 1995-08-10
FI913325A0 (en) 1991-07-09
NO912696D0 (en) 1991-07-09
IL92961A0 (en) 1990-09-17
KR900011763A (en) 1990-08-02
JPH0678337B2 (en) 1994-10-05
WO1990008146A1 (en) 1990-07-26
NO178193C (en) 1996-02-07
NO912696L (en) 1991-07-09

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