MY107031A - Peptides. - Google Patents

Peptides.

Info

Publication number
MY107031A
MY107031A MYPI91001370A MYPI19911370A MY107031A MY 107031 A MY107031 A MY 107031A MY PI91001370 A MYPI91001370 A MY PI91001370A MY PI19911370 A MYPI19911370 A MY PI19911370A MY 107031 A MY107031 A MY 107031A
Authority
MY
Malaysia
Prior art keywords
phe
pro
ala
substituted
arg
Prior art date
Application number
MYPI91001370A
Inventor
Jakob Leban Johann
Charles Kull Frederick
Original Assignee
The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Publication of MY107031A publication Critical patent/MY107031A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086Bombesin; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

THE PRESENT INVENTION PROVIDES A POLYPEPTIDE OF THE FORMULA (I): XX1TRPX2X3X4X5X6X7NH2 WHEREIN IS A GROUP X3 ARG (OR D-ARG)X9X10 AND X8 IS DES NH2PRO, TYRPRO, DES NH2TYRPRO, ADA, PRO, D-PRO OR IS DELETED; X9 IS GLY, ALA, D-ALA OR IS DELETED;X10 IS ASN, PHE, D-PHE,OR PHE OR D-PHE SUBSTITUTED BY ONE OR MORE HALO ATOMS; ORX IS A GROUP A- (CH2)N-CO-IN WHICH A IS A GROUP CONTAINING 1 TO 3 RINGS OF WHICH AT LEAST ONE RING IS AROMATIC, EACH RING SYSTEM BEING OPTIONALLY SUBSTITUTED; AND THE ALKYLENE GROUP IS OPTIONALLY SUBSTUTED BY ONE TO FOUR GROUPS SELECTED FROM AMINO, HYDROXY, C14 ALKOXY AND C14 ALKYL OPTIONALLY SUBSTITUTED BY HALO AND N IS -0 TO 4; OR X IS CYCLOPENTYL CARBONYL SUBSTITUTED BY A GROUP X8 ARG (OR D-ARG) X9X10 AS HEREINBEFORE DEFINED; X1 IS HIS, THIALA OR IS DELETED; X2 IS ALA, D-ALA, CPENC, D-TBUGLY OR PRO; X3 IS VAL OR VAL SUBSTITUTED BY ONE OR MORE HALO ATOMS; X4 IS GLY, ALA, D-ALA, SARCOSINE, PRO, D-PRO OR D-PHE; X5 IS HIS OR THIALA;X6 IS D-PRO,PRO, 2-PYRROLIDINYL-3-HYDROXYPROPIONYL OR D-PRO;X7 IS NLE, LEU, PHE, VAL, MOX, D-PHE, PHE, OR D-PHE SUBSTITUTED BY ONE OR MORE HALO ATOMS OR NAPHTHYLALA OR NAPTHYL D-ALA OR A HYDROPHONIC, SUBTITUTED AROMATIC AMINO ACID OR ARALKYLAMINE OR IS DELETED, AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. THE POLYPEPTIDES POSSESS ANTAGONIST PROPERTIES AGAINST BOMBESIN-LIKE PEPTIDES AND ARE OF VALUE IN THE TREATMENT OF MALIGNANT DISEASE.
MYPI91001370A 1990-07-31 1991-07-30 Peptides. MY107031A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909016810A GB9016810D0 (en) 1990-07-31 1990-07-31 Peptides

Publications (1)

Publication Number Publication Date
MY107031A true MY107031A (en) 1995-08-30

Family

ID=10679953

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI91001370A MY107031A (en) 1990-07-31 1991-07-30 Peptides.

Country Status (20)

Country Link
EP (1) EP0541654A1 (en)
JP (1) JPH05509100A (en)
AU (1) AU653544B2 (en)
CA (1) CA2088166A1 (en)
CZ (1) CZ8093A3 (en)
FI (1) FI930411A7 (en)
GB (1) GB9016810D0 (en)
HU (1) HUT63178A (en)
IE (1) IE912671A1 (en)
IL (1) IL99009A0 (en)
MC (1) MC2312A1 (en)
MY (1) MY107031A (en)
NO (1) NO930262D0 (en)
NZ (1) NZ239183A (en)
PL (1) PL167322B1 (en)
PT (1) PT98498A (en)
SK (1) SK3893A3 (en)
TW (1) TW234130B (en)
WO (1) WO1992002545A1 (en)
ZA (1) ZA915978B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US5436137A (en) * 1992-07-27 1995-07-25 Oregon Regional Primate Research Center DNA sequence which encodes a peptide capable of promoting acrosome reaction
US5620955A (en) * 1993-06-18 1997-04-15 Peptide Technologies Corporation Bombesin receptor antagonists and uses thereof
JP4954983B2 (en) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド BIR domain binding compound
RU2418807C2 (en) 2005-10-25 2011-05-20 Аегера Терапьютикс Инк. Compounds binding iap bir domains
MX340870B (en) 2010-02-12 2016-07-27 Pharmascience Inc Iap bir domain binding compounds.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds

Also Published As

Publication number Publication date
EP0541654A1 (en) 1993-05-19
MC2312A1 (en) 1993-09-27
ZA915978B (en) 1993-04-28
AU8311191A (en) 1992-03-02
WO1992002545A1 (en) 1992-02-20
PL167322B1 (en) 1995-08-31
HU9300239D0 (en) 1993-04-28
NZ239183A (en) 1993-07-27
PT98498A (en) 1992-05-29
GB9016810D0 (en) 1990-09-12
IE912671A1 (en) 1992-02-12
IL99009A0 (en) 1992-07-15
JPH05509100A (en) 1993-12-16
FI930411A0 (en) 1993-01-29
NO930262L (en) 1993-01-26
PL297652A1 (en) 1992-07-13
CA2088166A1 (en) 1992-02-01
TW234130B (en) 1994-11-11
SK3893A3 (en) 1993-07-07
AU653544B2 (en) 1994-10-06
FI930411A7 (en) 1993-01-29
CZ8093A3 (en) 1994-01-19
NO930262D0 (en) 1993-01-26
HUT63178A (en) 1993-07-28

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