MY108027A - Substitute tetrahydroisoquinolines and use as therepuetic agents - Google Patents
Substitute tetrahydroisoquinolines and use as therepuetic agentsInfo
- Publication number
- MY108027A MY108027A MYPI92002362A MYPI19922362A MY108027A MY 108027 A MY108027 A MY 108027A MY PI92002362 A MYPI92002362 A MY PI92002362A MY PI19922362 A MYPI19922362 A MY PI19922362A MY 108027 A MY108027 A MY 108027A
- Authority
- MY
- Malaysia
- Prior art keywords
- alkyl
- alkoxy
- phenyl
- optionally substituted
- halo
- Prior art date
Links
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 4
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical class O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 2
- -1 TETRAHYDROISOQUINOLINE COMPOUND Chemical class 0.000 abstract 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- UWYZHKAOTLEWKK-UHFFFAOYSA-N tetrahydro-isoquinoline Natural products C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
TETRAHYDROISOQUINOLINE COMPOUND OF FORMULA 1 AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, IN WHICH:-R1 REPRESENTS ONE OR MORE SUBSTITUENTS SELECTED FROM H, HALO, HYDROXY, ALKYL (OPTIONALLY SUBSTITUTED BY HYDROXY), ALKOXY, ALKYLTHIO, ALKYLSULPHINYL, ALKYL-SULPHONYL, NITRO, CYANO, POLYHALOALKYL, POLYHALOALKOXY, PHENYL (OPTIONALLY SUBSTITUTED BY ONE OR MORE OF HALO, ALKYL OR ALKOXY), OR R1 IS OPTIONALLY ALKYLATED CARBAMOYL;R2 REPRESENTS AN ALIPHATIC GROUP OPTIONALLY SUBSTITUTED BY HYDROXY OR ALKOXY; E REPRESENTS AN ALKYLANE CHAIN OPTIONALLY SUBSTITUTED BY ONE OR MORE ALKYL GROUPS;AND G REPRESENTS PHENYL OR PHENYL SUBSTITUTED BY ONE OR MORE OF ALKYL, ALKOXY, HALO, HYDROXY, POLYHALOALKYL, POLYHALOALKOXY, CYANO, ALKYLTHIO, ALKYLSULPHINYL, ALKYLSULPHONYL, PHENYL (OPTIONALLY SUBSTITUTED BY ONE OR MORE OF HALO, ALKYL OR ALKOXY), OPTIONALLY ALKYLATED CARBAMOYL, OR G REPRESENTS A PHENYL RING HAVING FUSED THERETO A HETEROCYLIC OR AROMATIC CARBOCYCLIC RING; AND 0-ACYLATED DERIVATIVES THEREOF WHICH PROVIDE LIPOPHILIC ESTERS HAVE UTILITY ANALGESIA AND IN THE TREATMENT OF PSYCHOSES (E.G SCHIZAPHRENIA), PARKINSON'S DISEASE, LESCH-NYAN SYNDROME, ATTENTION DEFICIT DISORDER OR COGNITIVE IMPAIRMENT OR IN THE RELIEF OF DRUG DEPENDENCE OR TARDIVE DYSKINESIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919127306A GB9127306D0 (en) | 1991-12-23 | 1991-12-23 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY108027A true MY108027A (en) | 1996-07-30 |
Family
ID=47521612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI92002362A MY108027A (en) | 1991-12-23 | 1992-12-22 | Substitute tetrahydroisoquinolines and use as therepuetic agents |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR100248558B1 (en) |
| MY (1) | MY108027A (en) |
| TW (1) | TW300889B (en) |
| UA (1) | UA32423C2 (en) |
| YU (1) | YU48648B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250111564A (en) | 2024-01-15 | 2025-07-22 | 우석대학교 산학협력단 | Flight planner system and method using urban air mobility and vertiport |
-
1992
- 1992-12-12 KR KR1019940702189A patent/KR100248558B1/en not_active Expired - Fee Related
- 1992-12-12 UA UA94005505A patent/UA32423C2/en unknown
- 1992-12-22 MY MYPI92002362A patent/MY108027A/en unknown
- 1992-12-23 YU YU110692A patent/YU48648B/en unknown
-
1993
- 1993-06-22 TW TW082104999A patent/TW300889B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| TW300889B (en) | 1997-03-21 |
| KR940703812A (en) | 1994-12-12 |
| YU110692A (en) | 1996-01-08 |
| KR100248558B1 (en) | 2000-04-01 |
| YU48648B (en) | 1999-06-15 |
| UA32423C2 (en) | 2000-12-15 |
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