MY113294A - A process for the preparation of a virus inactivated fraction containing factor viii by means of chromatographic methods - Google Patents
A process for the preparation of a virus inactivated fraction containing factor viii by means of chromatographic methodsInfo
- Publication number
- MY113294A MY113294A MYPI94002921A MYPI19942921A MY113294A MY 113294 A MY113294 A MY 113294A MY PI94002921 A MYPI94002921 A MY PI94002921A MY PI19942921 A MYPI19942921 A MY PI19942921A MY 113294 A MY113294 A MY 113294A
- Authority
- MY
- Malaysia
- Prior art keywords
- preparation
- factor viii
- fraction containing
- chromatographic methods
- containing factor
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000004587 chromatography analysis Methods 0.000 title abstract 3
- 229960000301 factor viii Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 238000009928 pasteurization Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A PROCESS FOR THE PREPARATION OF A VIRUS INACTIVATED FRACTION CONTAINING FACTOR VIII BY MEANS OF CHROMATOGRAPHIC METHODS, WHEREIN -PROCEEDING FROM A CRYOPRECIPITATE OR BLOOD PLASMA-OPTIONALLY FOLLOWED BY ALUMINUM HYDROXIDE TREATMENT, AFTER DISSOLUTION OF THE CRYOPRECIPITATE AT LEAST ONE SEPARATION STEP USING MEMBRANCE CHROMATOGRAPHY IS PERFORWED.THE FRACTIONS ARE SUBJECTED TO VIRUS INACTIVATION AND PREFERABLY TO AN ADDITIONAL PASTEURIZATION STEP.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4337573A DE4337573C1 (en) | 1993-11-04 | 1993-11-04 | Process for the preparation of a virus-inactivated factor VIII-containing fraction by means of chromatographic methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY113294A true MY113294A (en) | 2002-01-31 |
Family
ID=6501733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI94002921A MY113294A (en) | 1993-11-04 | 1994-11-03 | A process for the preparation of a virus inactivated fraction containing factor viii by means of chromatographic methods |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0726907B1 (en) |
| JP (1) | JP3739788B2 (en) |
| KR (1) | KR960705841A (en) |
| CN (1) | CN1109045C (en) |
| AT (1) | ATE228533T1 (en) |
| AU (1) | AU687451B2 (en) |
| CA (1) | CA2175670C (en) |
| CZ (1) | CZ290186B6 (en) |
| DE (2) | DE4337573C1 (en) |
| ES (1) | ES2182846T3 (en) |
| FI (1) | FI116569B (en) |
| HU (1) | HU222087B1 (en) |
| IL (1) | IL111263A (en) |
| MY (1) | MY113294A (en) |
| NO (1) | NO317112B1 (en) |
| PL (1) | PL181725B1 (en) |
| RU (1) | RU2148411C1 (en) |
| SK (1) | SK284215B6 (en) |
| UA (1) | UA43855C2 (en) |
| WO (1) | WO1995012609A1 (en) |
| ZA (1) | ZA948667B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19618851C1 (en) * | 1996-05-10 | 1997-07-24 | Octapharma Ag | Testing factor VIII containing preparations |
| US6057164A (en) * | 1996-03-08 | 2000-05-02 | Octapharma Ag | Process for testing suitability of protein fractions containing factor VIII |
| ES2137878B1 (en) * | 1997-12-01 | 2000-10-01 | Grifols Grupo Sa | PROCEDURE FOR OBTAINING AN ATTENUATED HUMAN PLASMA OF VIRUSES FOR THERAPEUTIC USE. |
| RU2253475C1 (en) * | 2004-02-02 | 2005-06-10 | Общество с ограниченной ответственностью "Гемоцентр" | Method of preparing factor viii preparation |
| RU2324495C1 (en) * | 2006-08-31 | 2008-05-20 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Method of making preparation of human blood coagulaton factor viii |
| KR20160104740A (en) * | 2008-06-24 | 2016-09-05 | 옥타파마 아게 | A process of purifying coagulation factor VIII |
| CA2821711C (en) | 2010-12-15 | 2017-10-10 | Baxter International Inc. | Eluate collection using conductivity gradient |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| US5043428A (en) * | 1984-08-31 | 1991-08-27 | Behringwerke Aktiengesellschaft | Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production |
| DE3432083A1 (en) * | 1984-08-31 | 1986-03-06 | Behringwerke Ag, 3550 Marburg | PASTEURIZED, ISOAGGLUTININ-FREE FACTOR VIII PREPARATION AND METHOD FOR THE PRODUCTION THEREOF |
| JPS62191042A (en) * | 1986-02-17 | 1987-08-21 | Kanegafuchi Chem Ind Co Ltd | Blood coagulation factor viii adsorbent and method for purifying blood coagulation factor viii using same |
| CA1339946C (en) * | 1987-03-31 | 1998-07-07 | Michael J. Griffith | Ultrapurification process for polypeptides |
| US4774323A (en) * | 1987-06-29 | 1988-09-27 | Rorer Pharmaceutical Corporation | Purification of von Willebrand Factor solutions using gel permeation chromatography |
| US4795806A (en) * | 1987-07-16 | 1989-01-03 | Miles Laboratories, Inc. | Phospholipid affinity purification of Factor VIII:C |
| CA2001720C (en) * | 1988-10-31 | 2001-10-02 | Randal A. Goffe | Membrane affinity apparatus and purification methods related thereto |
| ATE85221T1 (en) * | 1988-11-05 | 1993-02-15 | Octapharma Ag | PROCESS FOR THE PREPARATION OF A HIGH PURITY, NON-INFECTIOUS ANTIHAEMOPHILIA FACTOR USING CHROMATOGRAPHY. |
| CH678155A5 (en) * | 1989-08-09 | 1991-08-15 | Fischer Ag Georg | |
| AT399818B (en) * | 1992-04-24 | 1995-07-25 | Immuno Ag | METHOD FOR PRODUCING A HIGH PURIFIED VIRUS-SAFE FACTOR VIII PREPARATION |
-
1993
- 1993-11-04 DE DE4337573A patent/DE4337573C1/en not_active Revoked
-
1994
- 1994-09-30 HU HU9601192A patent/HU222087B1/en not_active IP Right Cessation
- 1994-09-30 AU AU78109/94A patent/AU687451B2/en not_active Expired
- 1994-09-30 WO PCT/EP1994/003258 patent/WO1995012609A1/en not_active Ceased
- 1994-09-30 EP EP94928846A patent/EP0726907B1/en not_active Expired - Lifetime
- 1994-09-30 SK SK566-96A patent/SK284215B6/en not_active IP Right Cessation
- 1994-09-30 CA CA002175670A patent/CA2175670C/en not_active Expired - Fee Related
- 1994-09-30 PL PL94314185A patent/PL181725B1/en not_active IP Right Cessation
- 1994-09-30 DE DE59410213T patent/DE59410213D1/en not_active Expired - Lifetime
- 1994-09-30 RU RU96110890A patent/RU2148411C1/en not_active IP Right Cessation
- 1994-09-30 JP JP51297795A patent/JP3739788B2/en not_active Expired - Fee Related
- 1994-09-30 ES ES94928846T patent/ES2182846T3/en not_active Expired - Lifetime
- 1994-09-30 CN CN94194020A patent/CN1109045C/en not_active Expired - Fee Related
- 1994-09-30 CZ CZ19961187A patent/CZ290186B6/en not_active IP Right Cessation
- 1994-09-30 KR KR1019960702337A patent/KR960705841A/en not_active Ceased
- 1994-09-30 UA UA96041756A patent/UA43855C2/en unknown
- 1994-09-30 AT AT94928846T patent/ATE228533T1/en active
- 1994-10-12 IL IL11126394A patent/IL111263A/en not_active IP Right Cessation
- 1994-11-03 ZA ZA948667A patent/ZA948667B/en unknown
- 1994-11-03 MY MYPI94002921A patent/MY113294A/en unknown
-
1996
- 1996-05-03 FI FI961900A patent/FI116569B/en active IP Right Grant
- 1996-05-03 NO NO19961816A patent/NO317112B1/en not_active IP Right Cessation
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