MY123352A - Dofetilide polymorphs - Google Patents
Dofetilide polymorphsInfo
- Publication number
- MY123352A MY123352A MYPI98004829A MYPI9804829A MY123352A MY 123352 A MY123352 A MY 123352A MY PI98004829 A MYPI98004829 A MY PI98004829A MY PI9804829 A MYPI9804829 A MY PI9804829A MY 123352 A MY123352 A MY 123352A
- Authority
- MY
- Malaysia
- Prior art keywords
- polymorphs
- dofetilide
- substantially pure
- relates
- dofetilide polymorphs
- Prior art date
Links
- IXTMWRCNAAVVAI-UHFFFAOYSA-N dofetilide Chemical compound C=1C=C(NS(C)(=O)=O)C=CC=1CCN(C)CCOC1=CC=C(NS(C)(=O)=O)C=C1 IXTMWRCNAAVVAI-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002994 dofetilide Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 238000000113 differential scanning calorimetry Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
THIS INVENTION RELATES TO A SUBSTANTIALLY PURE,CRYSTALLINE DOFETILIDE POLYMORPH P162 WHICH IS CHARACTERIZED BY THE FOLLOWING:DIFFERENTIAL SCANNING CALORIMETRY (DSC) IN WHICH IT EXHIBITS AN ENDOTHERMIC THERMAL EVENT AT THE ABOUT 162°C; POWDER X-RAY DIFFRACTION PATTERN (PXRD) WITH MAIN PEAK WITH INTERPLANAR SPACINGS AT DA21.303,10.597,7.053,5.288,4.856,4.793,4.569,4.504,4.430,4.256,4.230,4.133,3.956,3.611,3.866,3.674,3.606,3.524,3.424,3.384,3.309,3.255,3.171,3.083,3.038,3.021,2.893,2.842,2.776,2.679,2.598,2.557,2.503,2.482,2.436,2.419,2.399,2.345 AND 2.323; AND AN INFRARED (IR) SPECTRUM AS A MULL IN NUJOL WHICH SHOWS ABSORPTION BANDS AT 3246,3013,2807,2776,1907,1611,1593,1510,1398,1366,1357,1321,1300,1277,1251,1220,1171,1146,1106,1091,1051,1031,1023,994,966,934,925,903,851,825,808,774,723,657,603,586,559,538,528,509,499,461 AND 431CM-1. ALSO INCLUDED IN THIS INVENTION ARE DOFETILIDE POLYMORPHS P162A AND P143.THIS INVENTION FURTHER RELATES TO PROCESSES FOR THE PREPARATION OF POLYMORPHS P162,P162A,P143,IN ADDITION TO PHARMACEUTICAL COMPOSITIONS CONTAINING THESE POLYMORPHS.THIS INVENTION ADDITIONALLY RELATES TO METHODS OF TREATING HEART FAILURE AND CARDIAC ARRHYTHMIA USING SUBSTANTIALLY PURE DOFETILIDE POLYMORPHS P162,P162A OR P143.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9722662.5A GB9722662D0 (en) | 1997-10-27 | 1997-10-27 | Polymorphs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY123352A true MY123352A (en) | 2006-05-31 |
Family
ID=10821150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI98004829A MY123352A (en) | 1997-10-27 | 1998-10-23 | Dofetilide polymorphs |
Country Status (46)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10019067C1 (en) * | 2000-04-18 | 2001-10-04 | Lohmann Therapie Syst Lts | Transdermal plaster comprising dofetilide, is useful for treatment of cardiovascular disorders |
| US7326772B2 (en) * | 2005-05-12 | 2008-02-05 | Penta Biotech, Inc. | Peptide for assaying hERG channel binding |
| CZ2017772A3 (en) | 2017-12-01 | 2019-05-29 | Farmak, A.S. | Method of preparing N- [4- (2 - {[2- (4-methanesulfonamidophenoxy) ethyl] (methyl) amino} ethyl) phenyl] methanesulfonamide (Dofetilide) |
| US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
| US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
| US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US12396970B2 (en) | 2021-08-20 | 2025-08-26 | AltaThera Pharmaceuticals LLC | Anti-arrhythmic compositions and methods |
| US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EG18188A (en) * | 1986-05-01 | 1992-09-30 | Pfizer Ltd | Process for preparation anti-arhythmia agents |
| EP0898964A1 (en) * | 1997-08-19 | 1999-03-03 | Pfizer Inc. | Method for treating heart failure |
-
1997
- 1997-10-27 GB GBGB9722662.5A patent/GB9722662D0/en not_active Ceased
-
1998
- 1998-09-10 UA UA2000042087A patent/UA67755C2/en unknown
- 1998-10-08 TW TW087116747A patent/TW449589B/en not_active IP Right Cessation
- 1998-10-09 WO PCT/EP1998/006641 patent/WO1999021829A1/en not_active Ceased
- 1998-10-09 BR BR9813308-0A patent/BR9813308A/en not_active Application Discontinuation
- 1998-10-09 CA CA002307121A patent/CA2307121C/en not_active Expired - Fee Related
- 1998-10-09 PL PL340805A patent/PL197379B1/en unknown
- 1998-10-09 JP JP2000517941A patent/JP3569495B2/en not_active Expired - Fee Related
- 1998-10-09 NZ NZ503785A patent/NZ503785A/en unknown
- 1998-10-09 HU HU0004735A patent/HUP0004735A3/en unknown
- 1998-10-09 AT AT98965638T patent/ATE232199T1/en not_active IP Right Cessation
- 1998-10-09 CN CNB988106213A patent/CN1146537C/en not_active Expired - Fee Related
- 1998-10-09 DE DE69811256T patent/DE69811256T2/en not_active Expired - Fee Related
- 1998-10-09 ES ES98965638T patent/ES2190620T3/en not_active Expired - Lifetime
- 1998-10-09 HR HR970680A patent/HRP20000247B1/en not_active IP Right Cessation
- 1998-10-09 EA EA200000365A patent/EA002656B1/en not_active IP Right Cessation
- 1998-10-09 IL IL13543598A patent/IL135435A0/en not_active IP Right Cessation
- 1998-10-09 AU AU21512/99A patent/AU737668B2/en not_active Ceased
- 1998-10-09 TR TR2000/01135T patent/TR200001135T2/en unknown
- 1998-10-09 SK SK586-2000A patent/SK5862000A3/en unknown
- 1998-10-09 KR KR10-2000-7004471A patent/KR100366167B1/en not_active Expired - Fee Related
- 1998-10-09 SI SI9830347T patent/SI1027329T1/en unknown
- 1998-10-09 DK DK98965638T patent/DK1027329T3/en active
- 1998-10-09 PT PT98965638T patent/PT1027329E/en unknown
- 1998-10-09 EP EP98965638A patent/EP1027329B1/en not_active Expired - Lifetime
- 1998-10-09 ID IDW20000767A patent/ID24658A/en unknown
- 1998-10-09 US US09/423,986 patent/US6124363A/en not_active Expired - Lifetime
- 1998-10-09 YU YU24000A patent/YU24000A/en unknown
- 1998-10-22 PA PA19988462001A patent/PA8462001A1/en unknown
- 1998-10-22 AP APAP/P/1998/001371A patent/AP906A/en active
- 1998-10-23 PE PE1998001003A patent/PE122199A1/en not_active Application Discontinuation
- 1998-10-23 MY MYPI98004829A patent/MY123352A/en unknown
- 1998-10-23 AR ARP980105310A patent/AR015193A1/en unknown
- 1998-10-26 ZA ZA9809719A patent/ZA989719B/en unknown
- 1998-10-26 DZ DZ980242A patent/DZ2632A1/en active
- 1998-10-26 HN HN1998000165A patent/HN1998000165A/en unknown
- 1998-10-26 UY UY25222A patent/UY25222A1/en not_active IP Right Cessation
- 1998-10-26 MA MA25313A patent/MA24683A1/en unknown
- 1998-10-26 TN TNTNSN98193A patent/TNSN98193A1/en unknown
- 1998-10-27 CO CO98062885A patent/CO4970768A1/en unknown
- 1998-10-27 GT GT199800165A patent/GT199800165A/en unknown
- 1998-11-28 SA SA98190834A patent/SA98190834B1/en unknown
-
1999
- 1999-01-08 UY UY25341A patent/UY25341A1/en not_active IP Right Cessation
-
2000
- 2000-03-31 IS IS5426A patent/IS2179B/en unknown
- 2000-04-20 OA OA1200000117A patent/OA11350A/en unknown
- 2000-04-24 BG BG104373A patent/BG64125B1/en unknown
- 2000-04-27 NO NO20002191A patent/NO325630B1/en not_active IP Right Cessation
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