MY124346A - Medicated chewing gum delivery system for nicotine - Google Patents

Medicated chewing gum delivery system for nicotine

Info

Publication number
MY124346A
MY124346A MYPI99003826A MYPI9903826A MY124346A MY 124346 A MY124346 A MY 124346A MY PI99003826 A MYPI99003826 A MY PI99003826A MY PI9903826 A MYPI9903826 A MY PI9903826A MY 124346 A MY124346 A MY 124346A
Authority
MY
Malaysia
Prior art keywords
delivery system
minutes
nicotine
active
chewing
Prior art date
Application number
MYPI99003826A
Inventor
Edward J Cone
Carlos D Malvestutto
John M Pinney
Saul Shiffman
Jack E Henningfield
Joe Gitchell
Subraman R Cherukuri
Aradhana Sasan
Original Assignee
Jsr Llc
Biovail Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/146,696 external-priority patent/US6358060B2/en
Application filed by Jsr Llc, Biovail Tech Ltd filed Critical Jsr Llc
Publication of MY124346A publication Critical patent/MY124346A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)

Abstract

A CHEWING GUM DELIVERY SYSTEM HAS NICOTINE, GUM BASE AND A BUFFER SYSTEM WITH AN IMPROVED RELEASE RATE FOR THE NICOTINE. THE RESULTING DELIVERY SYSTEM ADVANTAGEOUSLY PROVIDES A CONVENIENT, RELIABLE, PRACTICAL, AND RELATIVELY PAINLESS SYSTEM FOR DELIVERING AN ACTIVE. THE DELIVERY SYSTEM IS CAPABLE OF DELIVERING INITIAL AND SECOND DOSES OF A CRAVING REDUCTION ACTIVE OR OTHER ACTIVES (E.G., NICOTINE), THE COMBINATION OF WHICH RAPIDLY REDUCE CRAVINGS, OR PROVIDES SOME OTHER PHARMACOLOGICAL EFFECT, AND PROVIDES THE PHARMACOLOGICAL EFFECT OR PROTECTION FROM SUCH CRAVINGS OVER A PROLONGED PERIOD OF TIME BEYOND THE INITIAL DOSE. NOTABLY, THE DELIVERY SYSTEM IS CAPABLE OF RAPIDLY ACHIEVING A PHARMACOLOGICALLY EFFECTIVE CONCENTRATION OF THE ACTIVE (E.G., NICOTINE) IN THE BLOODSTREAM (E.G., WITHIN 5 MINUTES, OR MORE DESIRABLY WITHIN 3 MINUTES, OR IN SOME CASES, WITHIN 1-2 MINUTES), AND IS ALSO CAPABLE OF KEEPING THE CONCENTRATION OF THE ACTIVE IN THE BLOODSTREAM AT OR NEAR THE PHARMACOLOGICALLY EFFECTIVE CONCENTRATION FOR AT LEAST 20 MINUTES AFTER CHEWING OF THE DELIVERY SYSTEM BEGINS, OR MORE DESIRABLY ABOUT 30 MINUTES TO ABOUT 50 MINUTES AFTER CHEWING BEGINS.
MYPI99003826A 1998-09-03 1999-09-03 Medicated chewing gum delivery system for nicotine MY124346A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/146,696 US6358060B2 (en) 1998-09-03 1998-09-03 Two-stage transmucosal medicine delivery system for symptom relief
IE980991 1998-11-27
US36089699A 1999-07-26 1999-07-26

Publications (1)

Publication Number Publication Date
MY124346A true MY124346A (en) 2006-06-30

Family

ID=27270586

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI99003826A MY124346A (en) 1998-09-03 1999-09-03 Medicated chewing gum delivery system for nicotine

Country Status (4)

Country Link
AR (1) AR022374A1 (en)
DE (1) DE69938347T2 (en)
DK (1) DK1107730T3 (en)
MY (1) MY124346A (en)

Also Published As

Publication number Publication date
AR022374A1 (en) 2002-09-04
DE69938347T2 (en) 2009-04-23
DK1107730T3 (en) 2008-07-14
DE69938347D1 (en) 2008-04-24

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