MY127771A - Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them - Google Patents

Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them

Info

Publication number
MY127771A
MY127771A MYPI20031160A MYPI20031160A MY127771A MY 127771 A MY127771 A MY 127771A MY PI20031160 A MYPI20031160 A MY PI20031160A MY PI20031160 A MYPI20031160 A MY PI20031160A MY 127771 A MY127771 A MY 127771A
Authority
MY
Malaysia
Prior art keywords
compounds
bicyclic heterocyclic
preparing
pharmaceutical compositions
compositions containing
Prior art date
Application number
MYPI20031160A
Inventor
Frank Dr Himmelsbach
Birgit Dr Jung
Flavio Dr Solca
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10214412A external-priority patent/DE10214412A1/en
Priority claimed from DE2002131711 external-priority patent/DE10231711A1/en
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MY127771A publication Critical patent/MY127771A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

THE PRESENT INVENTION RELATES TO BICYCLIC HETEROCYCLIC GROUPS OF GENERAL FORMULA (FORMULA Ι) WHEREIN Ra, Rb, Rc, Rd AND X ARE DEFINED AS IN CLAIM 1, THE TAUTOMERS, THE STEREOISOMERS, THE MIXTURES AND THE SALTS THEREOF, PARTICULARLY THE PHYSIOLOGICALLY ACCEPTABLE SALTS THEREOF WITH INORGANIC ACIDS WHICH HAVE VALUABLE PHARMACOLOGICAL PROPERTIES, PARTICULARLY AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES, THE USE THEREOF FOR TREATING DISEASES, PARTICULARLY TUMORAL DISEASES, AS WELL AS BENIGN PROSTATE HYPERPLASIA (BPH), DISEASES OF THE LUNGS AND RESPIRATORY TRACT, AND THE PREPARATION THEREOF.
MYPI20031160A 2002-03-30 2003-03-28 Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them MY127771A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10214412A DE10214412A1 (en) 2002-03-30 2002-03-30 Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and process for their preparation
DE2002131711 DE10231711A1 (en) 2002-07-13 2002-07-13 New 4-amino-quinazoline or quinoline derivatives, are tyrosine kinase-mediated signal transduction inhibitors useful e.g. for treating tumors or respiratory or gastrointestinal diseases

Publications (1)

Publication Number Publication Date
MY127771A true MY127771A (en) 2006-12-29

Family

ID=28676040

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20031160A MY127771A (en) 2002-03-30 2003-03-28 Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them

Country Status (23)

Country Link
EP (1) EP1492536B1 (en)
JP (1) JP4776882B2 (en)
KR (1) KR101064530B1 (en)
CN (1) CN1642552B (en)
AR (1) AR039187A1 (en)
AT (1) ATE557008T1 (en)
AU (1) AU2003226705B2 (en)
BR (1) BR0308902A (en)
CA (1) CA2476008C (en)
EA (2) EA200701302A1 (en)
HR (1) HRP20040898A2 (en)
IL (1) IL164167A0 (en)
ME (1) MEP47208A (en)
MX (1) MXPA04009536A (en)
MY (1) MY127771A (en)
NO (1) NO329271B1 (en)
NZ (1) NZ536114A (en)
PE (1) PE20040169A1 (en)
PL (1) PL371188A1 (en)
RS (1) RS85404A (en)
TW (2) TW201024269A (en)
UY (1) UY27737A1 (en)
WO (1) WO2003082290A1 (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1044769B (en) 1999-06-21 2005-02-25 贝林格尔英格海姆法玛两合公司 Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
US7576074B2 (en) * 2002-07-15 2009-08-18 Rice Kenneth D Receptor-type kinase modulators and methods of use
BRPI0410720A (en) * 2003-05-27 2006-06-20 Pfizer Prod Inc quinazolines and pyrido [3,4-d] pyrimidines as tyrosine kinase receptor inhibitors
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
AU2004253967B2 (en) 2003-07-03 2010-02-18 Cytovia, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
DE10334226A1 (en) * 2003-07-28 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
UY28441A1 (en) * 2003-07-29 2005-02-28 Astrazeneca Ab QUINAZOLINE DERIVATIVES
GB0317665D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
EP1664028A1 (en) * 2003-09-16 2006-06-07 AstraZeneca AB Quinazoline derivatives as tyrosine kinase inhibitors
ATE395346T1 (en) * 2003-09-16 2008-05-15 Astrazeneca Ab QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS
CN1882570B (en) * 2003-09-19 2010-12-08 阿斯利康(瑞典)有限公司 Quinazoline derivatives
ES2279441T3 (en) * 2003-09-19 2007-08-16 Astrazeneca Ab DERIVATIVES OF QUINAZOLINA.
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
US7456189B2 (en) 2003-09-30 2008-11-25 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE10345875A1 (en) * 2003-09-30 2005-04-21 Boehringer Ingelheim Pharma Bicyclic heterocycles, pharmaceutical compositions containing them, their use and methods of preparation
DE10350717A1 (en) * 2003-10-30 2005-06-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
MXPA06007018A (en) * 2003-12-18 2006-08-31 Janssen Pharmaceutica Nv 3-cyano-quinoline derivatives with antiproliferative activity.
MXPA06007017A (en) 2003-12-18 2006-08-31 Janssen Pharmaceutica Nv Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents.
DE602005010824D1 (en) 2004-02-03 2008-12-18 Astrazeneca Ab quinazoline derivatives
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
NI200700147A (en) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv QUINAZOLINE DERIVATIVES KINE INHIBITORS TARGETING MULTIP
ATE501148T1 (en) 2004-12-14 2011-03-15 Astrazeneca Ab PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTI-TUMOR AGENTS
PE20060777A1 (en) 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP1845992A1 (en) * 2005-02-04 2007-10-24 Boehringer Ingelheim International GmbH Use of tyrosine kinase inhibitors for the treatment of chronic rhinosinusitis
WO2006081741A1 (en) * 2005-02-05 2006-08-10 Piaoyang Sun Quinazoline compounds or their medical salts and preparation and medical usage thereof
KR20070107151A (en) * 2005-02-26 2007-11-06 아스트라제네카 아베 Quinazolin Derivatives as Tyrosine Kinase Inhibitors
CA2619037A1 (en) * 2005-08-22 2007-03-01 Boehringer Ingelheim International Gmbh Bicyclic heterocycles medicaments comprising said compounds use and method for production thereof
ATE488513T1 (en) 2005-09-20 2010-12-15 Astrazeneca Ab 4-(1H-INDAZOLE-5-YLAMINO)QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER
JP5688877B2 (en) 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Quinazoline derivatives for the treatment of cancer diseases
JP2009518450A (en) * 2005-12-12 2009-05-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Bicyclic heterocyclic compound, drug containing the compound, use and production method thereof
US20090306105A1 (en) * 2006-03-09 2009-12-10 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing these compounds, their use and process for preparing them
JP2009542778A (en) 2006-07-13 2009-12-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ MTKI quinazoline derivative
AU2007296746B2 (en) * 2006-09-11 2012-07-05 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
WO2008033747A2 (en) * 2006-09-11 2008-03-20 Curis, Inc. Multi-functional small molecules as anti-proliferative agents
AU2007299080B2 (en) 2006-09-18 2013-04-18 Boehringer Ingelheim International Gmbh Method for treating cancer harboring EGFR mutations
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
AU2008212999A1 (en) 2007-02-06 2008-08-14 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
EP1956010A1 (en) * 2007-02-06 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclical heterocycles, medicines containing these compounds, their application and method for their production
TWI377944B (en) * 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
AU2008281849B2 (en) 2007-07-27 2013-11-28 Janssen Pharmaceutica Nv Pyrrolopyrimidines
US8497369B2 (en) * 2008-02-07 2013-07-30 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
JP5739802B2 (en) * 2008-05-13 2015-06-24 アストラゼネカ アクチボラグ 4- (3-Chloro-2-fluoroanilino) -7-methoxy-6-{[1- (N-methylcarbamoylmethyl) piperidin-4-yl] oxy} quinazoline fumarate
US8263768B2 (en) * 2008-08-08 2012-09-11 Boehringer Ingelheim International Gmbh Process for the stereoselective preparation of bicyclic heterocycles
EP2313398A1 (en) * 2008-08-08 2011-04-27 Boehringer Ingelheim International GmbH Cyclohexyloxy-substituted heterocyclics, medicines containing these compounds and method for the production thereof
EP2313397B1 (en) * 2008-08-08 2016-04-20 Boehringer Ingelheim International GmbH Cyclohexyloxy substituted heterocycles, medicine containing these connections, their application and production method
CN101659658B (en) * 2008-08-29 2014-04-02 北大方正集团有限公司 Quinoline substituted by cyan
CN101659657B (en) * 2008-08-29 2014-05-14 北大方正集团有限公司 Quinoline substituted by cyan and preparation method and applications thereof
US8629153B2 (en) * 2008-09-03 2014-01-14 Boehringer Ingelheim International Gmbh Use of quinazoline derivatives for the treatment of viral diseases
PT2451445T (en) 2009-07-06 2019-07-10 Boehringer Ingelheim Int Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
WO2011035540A1 (en) 2009-09-28 2011-03-31 齐鲁制药有限公司 4-(substituted anilino)quinazoline derivatives as tyrosine kinase inhibitors
EP2414338A1 (en) * 2010-02-15 2012-02-08 Boehringer Ingelheim International GmbH Salts and hydrates of 4-[(3-chlor-4-fluoro-phenyl)amino]-6-(cis-4-{n-[(morph-1-olino-4-yl)carbonyl]-n-methyl-amino}-cyclohexane-1-yloxy)-7-methoxy-quinazoline, their use as drugs and their production
CN102452988B (en) * 2010-10-27 2016-01-27 中国科学院化学研究所 A kind of quinazoline derivant and preparation method thereof
AP3531A (en) 2011-02-01 2016-01-13 Boehringer Ingelheim Int 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof
KR101317809B1 (en) 2011-06-07 2013-10-16 한미약품 주식회사 Pharmaceutical composition comprising amide derivative inhibiting the growth of cancer cell and non-metalic salt lubricant
KR20140128318A (en) 2012-02-09 2014-11-05 베링거 인겔하임 인터내셔날 게엠베하 Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes
EP2752413B1 (en) 2012-03-26 2016-03-23 Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences Quinazoline derivative and application thereof
WO2014012859A1 (en) 2012-07-19 2014-01-23 Boehringer Ingelheim International Gmbh Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as medicament and the preparation thereof
KR20140096571A (en) 2013-01-28 2014-08-06 한미약품 주식회사 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one
EP2964638B1 (en) * 2013-03-06 2017-08-09 Astrazeneca AB Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
TWI771327B (en) * 2016-10-05 2022-07-21 英商使命醫療公司 Novel compounds
EP3962908A4 (en) * 2019-04-25 2022-10-26 Board of Regents, The University of Texas System HETEROCYCLIC TYROSINE KINASE INHIBITORS
EP4055014B1 (en) 2019-11-06 2025-04-30 Yuhan Corporation PYRROLIDINE AND PIPERIDINE COMPOUNDS
TW202208337A (en) * 2020-05-04 2022-03-01 美商佛拉斯托醫療公司 Imino sulfanone inhibitors of enpp1
IL310870A (en) * 2021-08-24 2024-04-01 Arthrosi Therapeutics Inc Quinazoline compounds for the treatment of diseases
WO2025152954A1 (en) * 2024-01-15 2025-07-24 上海脉博实业有限公司 Benzopyrimidine compound, preparation method therefor, pharmaceutical composition and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
DE19911509A1 (en) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
GB9910577D0 (en) * 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
DE10042059A1 (en) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE10042058A1 (en) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
TWI324597B (en) * 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives

Also Published As

Publication number Publication date
BR0308902A (en) 2005-01-04
AR039187A1 (en) 2005-02-09
PE20040169A1 (en) 2004-05-24
EA200701302A1 (en) 2007-12-28
RS85404A (en) 2007-02-05
CN1642552A (en) 2005-07-20
KR101064530B1 (en) 2011-09-14
TWI331604B (en) 2010-10-11
EA009300B1 (en) 2007-12-28
NO329271B1 (en) 2010-09-20
CN1642552B (en) 2010-05-12
EP1492536B1 (en) 2012-05-09
CA2476008C (en) 2011-12-13
UY27737A1 (en) 2003-10-31
WO2003082290A1 (en) 2003-10-09
MXPA04009536A (en) 2005-01-25
CA2476008A1 (en) 2003-10-09
JP4776882B2 (en) 2011-09-21
PL371188A1 (en) 2005-06-13
EP1492536A1 (en) 2005-01-05
JP2005529090A (en) 2005-09-29
TW200406211A (en) 2004-05-01
NZ536114A (en) 2007-11-30
EA200401191A1 (en) 2005-04-28
ATE557008T1 (en) 2012-05-15
TW201024269A (en) 2010-07-01
HK1079095A1 (en) 2006-03-31
HRP20040898A2 (en) 2005-10-31
KR20040094898A (en) 2004-11-10
MEP47208A (en) 2011-02-10
IL164167A0 (en) 2005-12-18
AU2003226705A1 (en) 2003-10-13
NO20043997L (en) 2004-10-27
AU2003226705B2 (en) 2008-11-06

Similar Documents

Publication Publication Date Title
MY127771A (en) Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
MY136086A (en) Quinazoline derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
TW200505912A (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
MY123642A (en) Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, and processes for preparing them.
YU14003A (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
TW200510341A (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
CA2417652A1 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
BG105765A (en) 4-AMINO-HYANZOLINE AND XINOLINE DERIVATIVES WITH INHIBITORS ON SIGNAL TRANSLATION, THERAPISED BY TYROSINKINASES
MEP45508A (en) Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
MXPA03001377A (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof.
CA2417050A1 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
CA2403152A1 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
MY150290A (en) Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production
IL115185A0 (en) Pyrimido (5,4-d) pyrimidines pharmaceutical compositions containing them their use and processes for their preparation
TW200730508A (en) Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same
EA201300872A1 (en) DIMALEAT 9- [4- (3-Chlor-2-Fluoro-phenylamino) -7-METHOXYHINAZOLIN-6-ILOXI] -1,4-Diazaspiro [5.5] UNDECAN-5-SHE, ITS USE AS A MEDICINE MEDICINE HEAT
EA200901041A1 (en) BICYCLIC HETEROCYCLES CONTAINING THESE COMPOUNDS MEDICINES, THEIR APPLICATION AND METHOD OF OBTAINING THEM
WO2000055162A3 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
WO2007023073A3 (en) Bicyclic heterocycles medicaments comprising said compounds use and method for production thereof
MY140484A (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
YU60501A (en) 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases