MY128486A - Acid addition salts of morphine alkaloids and the use thereof - Google Patents
Acid addition salts of morphine alkaloids and the use thereofInfo
- Publication number
- MY128486A MY128486A MYPI98004419A MYPI9804419A MY128486A MY 128486 A MY128486 A MY 128486A MY PI98004419 A MYPI98004419 A MY PI98004419A MY PI9804419 A MYPI9804419 A MY PI9804419A MY 128486 A MY128486 A MY 128486A
- Authority
- MY
- Malaysia
- Prior art keywords
- substituted
- acids
- group
- acid addition
- optionally
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 229930013053 morphinan alkaloid Natural products 0.000 title abstract 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- -1 CARBOXYL GROUP Chemical group 0.000 abstract 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001559 benzoic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A SUBSTANCE CONSISTING OF AN ACID ADDITION SALT OF A MORPHINE ALKALOID AND AN ORGANIC ACID IS PROVIDED.THE ORGANIC ACID IS SELECTED FROM :- MONOESTERS OF C3- TO C16- DICARBOXYLIC ACIDS WITH MONO-HYDRIC C1- TO C4- ALCOHOLS,- C2-TO C16-SULFONIC ACIDS, - SUBSTITUTED BENZOIC ACIDS, SELECTED FROM THE GROUP OF HALOGEN,HYDROXY, ALKYL, HYDROXYALKYL, ALKOXYALKYL AND/OR ALKOXY-SUBSTITUTED BENZOIC ACID, AS WELL AS OF THE AMINOSUBSTITUTED BENZOIC ACIDS, WHICH MAY OPTIONALLY BE ALKYLATED AT THE N ATOM,- SUBSTITUTED OR NON-SUBSTITUTED 5-RING OR 6-RING HETROCYCLES COMPRISING AT LEAST ONE N OR S ATOM AND HAVING A CARBOXYL GROUP FUNCTION, - SATURATED OR UNSATURATED, OPTIONALLY SUBSTITUTED, OXOCARBOXYLIC ACIDS HAVING 5 TO 10 C ATOMS, - PHENYL-SUBSTITUTED OR PHENOXY-SUBSTITUTED SATURATED C2- TO C4-CARBOXYLIC ACIDS.@- ALIPHATIC, AROMATIC OR HETEROCYCLIC C2- TO C12-AMINO ACIDS, WHEREIN ONE AMINO GROUP IS SUBSTITUTED WITH AN-OPTIONALLY SUBSTITUTED - C2- TO C6- ALKANOYL GROUP OR AN-OPTIONALLY SUBSTITUTED-BENZOYL GROUP.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742296 | 1997-09-25 | ||
| DE19834005A DE19834005A1 (en) | 1997-09-25 | 1998-07-29 | Acid addition salts of morphine alkaloids and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY128486A true MY128486A (en) | 2007-02-28 |
Family
ID=7843572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI98004419A MY128486A (en) | 1997-09-25 | 1998-09-25 | Acid addition salts of morphine alkaloids and the use thereof |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR100555884B1 (en) |
| DE (2) | DE19834005A1 (en) |
| MY (1) | MY128486A (en) |
| ZA (1) | ZA988710B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924797D0 (en) * | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
| DE10305137A1 (en) * | 2003-02-07 | 2004-08-26 | Novosis Ag | Transdermal therapeutic delivery systems with a butenolide |
| DE102006054732B4 (en) | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with ion-pair microreservoirs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
-
1998
- 1998-07-29 DE DE19834005A patent/DE19834005A1/en not_active Withdrawn
- 1998-09-05 DE DE59803461T patent/DE59803461D1/en not_active Expired - Lifetime
- 1998-09-05 KR KR1020007003244A patent/KR100555884B1/en not_active Expired - Fee Related
- 1998-09-23 ZA ZA988710A patent/ZA988710B/en unknown
- 1998-09-25 MY MYPI98004419A patent/MY128486A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010030727A (en) | 2001-04-16 |
| DE19834005A1 (en) | 1999-04-01 |
| KR100555884B1 (en) | 2006-03-03 |
| DE59803461D1 (en) | 2002-04-25 |
| ZA988710B (en) | 1999-04-01 |
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