MY131321A - "antiviral peptides" - Google Patents

"antiviral peptides"

Info

Publication number
MY131321A
MY131321A MYPI93000495A MYPI9300495A MY131321A MY 131321 A MY131321 A MY 131321A MY PI93000495 A MYPI93000495 A MY PI93000495A MY PI9300495 A MYPI9300495 A MY PI9300495A MY 131321 A MY131321 A MY 131321A
Authority
MY
Malaysia
Prior art keywords
alkyl
cycloalkyl
heterocyclyl
aryl
group
Prior art date
Application number
MYPI93000495A
Inventor
Colin William Dr Greengrass
Stephen Derek Albert Dr Street
Peter John Dr Whittle
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MY131321A publication Critical patent/MY131321A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOUNDS OF THE FORMULA : (FORMULA 1)AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND BIOPRECURSORS THEREOF, WHEREIN-: RI IS C1-C6 ALKYL, C3-C8 CYCLOALKYL, ARYL, HETEROCYCLYL OR CONR9R10;R2 IS CI-C6 ALKYL, C3-C8 CYCLOALKYL (C1-C4) ALKYL, ARYL (C1-C4) ALKYL OR HETEROCYCLYL (C1-C4) ALKYL;R3 IS C1-C6 ALKYL, C3-C8 CYCLOALKYL, C3-C8 CYCLOALKYL (C1-C4) ALKYL, ARYL(C1-C4) ALKYL, ARYL (C2-C4)- ALKENYL, HETEROCYCLYL (C1-C4) ALKYL OR HETEROCYCLYL (C2-C4)- ALKENYL;R4 IS C1-C6 ALKYL, C3-C8 CYCLOALKYL, ARYL OR HETEROCYCLYL; EACH OF R5, R6, R7 AND R8 INDEPENDENTLY H, C1-C6 ALKYL OR C3- C8 CYCLOALKYL; OR R5 AND R6, OR R7 AND R8 MAY BE JOINED TOGETHER TO FORM A 3 TO 8 MEMBERED CARBOCYCLIC RING;X IS A 4-10 MEMBERED MONO OR BICYCLIC HETEROCYCLIC GROUP CONTAINING CARBON RING ATOMS AND ONE RING NITROGEN ATOM THROUGH WHICH THE GROUP IS ATTACHED TO THE ADJACENT CARBONYL GROUP; THE GROUP MAY BE SATURATED OR PARTIALLY UNSATURATED AND, IN ADDITION TO THE - (CR7R8)M -HET SUBSTITUENT, IT MAY BE SUBSTITUTED BY UP TO 4 FURTHER SUBSTITUENTS INDEPENDENTLY CHOSEN FROM F, C1-C6 ALKYL, C3-C8 CYCLOALKYL, OR11 OR NR9R10;HET IS AN IMIDAZOLYL OR TRIALZOLYL GROUP EITHER OF WHICH MAY OPTIONALLY BE SUBSTITUTED BY C1-C6 ALKYL, C3-C7 CYCLOALKYL, NR9R10 0R CONR9R10,EACH OF R9 AND R10 IS INDEPENDENTLY H, C1-C6 ALKYL OR C3-C8 CYCLOALKYL, OR R9 AND R10 MAY BE JOINED TOGETHER TO FORM, WITH THE NITROGEN TO WHICH THEY ARE ATTACHED, A 4 TO 8 MEMBERED NITROGEN - CONTAINING HETEROCYCLIC GROUP, R11 IS H, C1-C6 ALKYL OR C3-C8 CYCLOALKYL;N AND M ARE EACH INDEPENDENTLY O, 1 OR 2; WHEREIN ANY ALKYL OR CYCLOALKYL GROUP INCLUDED IN THE AFOREMENTIONED DEFINITIONS MAY OPTIONALLY BE FULLY OR PARTIALLY SUBSTITUTED BY FLUORINE;ARE INHIBTORS OF RETROVIRAL PROTEASES OF UTILITY IN THE TREATMENT AND PROPYLAXIC OF HUMAN RETROVIRAL INFECTIONS.
MYPI93000495A 1992-03-25 1993-03-19 "antiviral peptides" MY131321A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929206462A GB9206462D0 (en) 1992-03-25 1992-03-25 Antiviral peptides

Publications (1)

Publication Number Publication Date
MY131321A true MY131321A (en) 2007-08-30

Family

ID=10712788

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI93000495A MY131321A (en) 1992-03-25 1993-03-19 "antiviral peptides"

Country Status (11)

Country Link
CN (1) CN1077716A (en)
GB (1) GB9206462D0 (en)
HR (1) HRP930283A2 (en)
IL (1) IL105099A0 (en)
IS (1) IS3988A (en)
MA (1) MA22838A1 (en)
MX (1) MX9301694A (en)
MY (1) MY131321A (en)
OA (1) OA10054A (en)
UY (1) UY23555A1 (en)
ZA (1) ZA932079B (en)

Also Published As

Publication number Publication date
OA10054A (en) 1996-10-14
GB9206462D0 (en) 1992-05-06
IS3988A (en) 1993-09-26
ZA932079B (en) 1994-09-26
MX9301694A (en) 1993-09-01
UY23555A1 (en) 1993-09-08
IL105099A0 (en) 1993-07-08
HRP930283A2 (en) 1997-08-31
MA22838A1 (en) 1993-10-01
CN1077716A (en) 1993-10-27

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