MY132049A - Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands - Google Patents
Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligandsInfo
- Publication number
- MY132049A MY132049A MYPI9503592A MY132049A MY 132049 A MY132049 A MY 132049A MY PI9503592 A MYPI9503592 A MY PI9503592A MY 132049 A MY132049 A MY 132049A
- Authority
- MY
- Malaysia
- Prior art keywords
- aminomethyl
- imidazole derivatives
- substituted imidazole
- dopamine receptor
- certain
- Prior art date
Links
- 102000015554 Dopamine receptor Human genes 0.000 title abstract 2
- 108050004812 Dopamine receptor Proteins 0.000 title abstract 2
- -1 4-aminomethyl-2-substituted imidazole Chemical class 0.000 title 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
DISCLOSED ARE COMPOUNDS OF THE FORMULA :(FORMULA I)WHEREIN R1 REPRESENTS OPTIONALLY SUBSTITUTED ARYL, HETEROARYL, ARYLALKYL, OR CYCLOALKYL GROUPS; X, Z, AND Y ARE OPTIONALLY SUBSTITUTED NITROGEN OR CARBON ATOMS; R3 AND R4 ARE INORGANIC SUBSTITUTENTS WHICH MAY TOGETHER FORM RING STRUCTURES; M IS ZERO, ONE OR TWO; AND R5 AND R6 ARE ARE ORGANIC OR INORGANIC SUBSTITUENTS; AND THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS THEREOF, WHICH COMPOUNDS ARE HIGHLY SELECTIVE PARTIAL AGONISTS OR ANTAGONISTS AT BRAIN DOPAMINE RECEPTOR SUBTYPES OR PRODRUGS THEREOF AND ARE USEFUL IN THE DIAGNOSIS AND TREATMENT OF EFFECTIVE DISORDES SUCH AS SCHIZOPHRENIA AND DEPRESSION AS WELL AS CERTAIN MOVEMENT DISORDES SUCH AS PARKINSONISM.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34415494A | 1994-11-23 | 1994-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY132049A true MY132049A (en) | 2007-09-28 |
Family
ID=23349285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI9503592 MY132049A (en) | 1994-11-23 | 1995-11-23 | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands |
Country Status (3)
| Country | Link |
|---|---|
| IL (1) | IL116090A0 (en) |
| MY (1) | MY132049A (en) |
| ZA (1) | ZA959911B (en) |
-
1995
- 1995-11-21 IL IL11609095A patent/IL116090A0/en unknown
- 1995-11-22 ZA ZA9509911A patent/ZA959911B/en unknown
- 1995-11-23 MY MYPI9503592 patent/MY132049A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL116090A0 (en) | 1996-01-31 |
| ZA959911B (en) | 1997-08-22 |
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