MY132470A - Substituted oxobutyric acids as matrix metalloprotease inhibitors - Google Patents

Substituted oxobutyric acids as matrix metalloprotease inhibitors

Info

Publication number: MY132470A
Authority: MY; Malaysia
Prior art keywords: matrix metalloprotease; substituted; metalloprotease inhibitors; formula; carbons
Prior art date: 1996-05-15

Application number

MYPI97002045A

Other languages

English (en)

Inventor

r brittelli David

Van Zandt Michael

r dixon Brian

Chen Jinshan

Original Assignee

Bayer Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-15

Filing date

1997-05-09

Publication date

2007-10-31

1997-05-09 Application filed by Bayer Corp filed Critical Bayer Corp

2007-10-31 Publication of MY132470A publication Critical patent/MY132470A/en

Links

239000011159 matrix material Substances 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
239000003475 metalloproteinase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
-1 ALLYL Chemical group 0.000 abstract 1
102000005741 Metalloproteases Human genes 0.000 abstract 1
108010006035 Metalloproteases Proteins 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Oncology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

MYPI97002045A 1996-05-15 1997-05-09 Substituted oxobutyric acids as matrix metalloprotease inhibitors MY132470A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US64838496A	1996-05-15	1996-05-15

Publications (1)

Publication Number	Publication Date
MY132470A true MY132470A (en)	2007-10-31

Family

ID=24600568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MYPI97002045A MY132470A (en)	1996-05-15	1997-05-09	Substituted oxobutyric acids as matrix metalloprotease inhibitors

Country Status (18)

Country	Link
EP (1)	EP0912487A1 (id)
JP (1)	JP3417951B2 (id)
CN (1)	CN1163466C (id)
AR (1)	AR007096A1 (id)
AU (1)	AU727648B2 (id)
CA (1)	CA2253869C (id)
CO (1)	CO4990925A1 (id)
HR (1)	HRP970246B1 (id)
ID (1)	ID20291A (id)
MY (1)	MY132470A (id)
PA (1)	PA8429401A1 (id)
PE (1)	PE65998A1 (id)
SV (1)	SV1997000034A (id)
TN (1)	TNSN97085A1 (id)
TW (1)	TW467892B (id)
WO (1)	WO1997043238A1 (id)
YU (1)	YU18797A (id)
ZA (1)	ZA974032B (id)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6288063B1 (en)	1998-05-27	2001-09-11	Bayer Corporation	Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
GB0321538D0 (en) *	2003-09-13	2003-10-15	Glaxo Group Ltd	Therapeutically useful compounds
WO2009022740A1 (ja) *	2007-08-15	2009-02-19	Kyorin Pharmaceutical Co., Ltd.	イブジラストを有効成分とする脳動脈瘤の予防、形成抑制又は治療剤
US20170022171A1 (en)	2014-04-03	2017-01-26	Bayer Pharma Aktiengesellschaft	2,5-disubstituted cyclopentanecarboxylic acids and their use
US20170119776A1 (en)	2014-04-03	2017-05-04	Bayer Pharma Aktiengesellschaft	Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
CA2944614A1 (en)	2014-04-03	2015-10-08	Bayer Pharma Aktiengesellschaft	2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0905126B1 (en) *	1994-01-22	2002-12-04	British Biotech Pharmaceuticals Limited	Metalloproteinase inhibitors
NZ323329A (en)	1995-12-22	1999-02-25	Warner Lambert Co	4-phenyl-piperidin-1-yl butyric acid derivatives and medicaments
HRP970242A2 (en)	1996-05-15	1998-04-30	Bayer Ag	Inhibition of matrix metalloproteases by 2-(omega-aroylalkyl)-4-biaryl-oxobutric acids

1997
- 1997-05-09 CO CO97025164A patent/CO4990925A1/es unknown
- 1997-05-09 ZA ZA9704032A patent/ZA974032B/xx unknown
- 1997-05-09 MY MYPI97002045A patent/MY132470A/en unknown
- 1997-05-09 HR HR970246A patent/HRP970246B1/xx not_active IP Right Cessation
- 1997-05-09 TN TNTNSN97085A patent/TNSN97085A1/fr unknown
- 1997-05-12 WO PCT/US1997/007975 patent/WO1997043238A1/en not_active Ceased
- 1997-05-12 EP EP97926454A patent/EP0912487A1/en not_active Withdrawn
- 1997-05-12 AU AU31219/97A patent/AU727648B2/en not_active Ceased
- 1997-05-12 YU YU18797A patent/YU18797A/sr unknown
- 1997-05-12 CN CNB971964599A patent/CN1163466C/zh not_active Expired - Fee Related
- 1997-05-12 TW TW086106284A patent/TW467892B/zh not_active IP Right Cessation
- 1997-05-12 PE PE1997000362A patent/PE65998A1/es not_active Application Discontinuation
- 1997-05-12 AR ARP970101976A patent/AR007096A1/es unknown
- 1997-05-12 CA CA002253869A patent/CA2253869C/en not_active Expired - Fee Related
- 1997-05-12 SV SV1997000034A patent/SV1997000034A/es not_active Application Discontinuation
- 1997-05-12 JP JP54100297A patent/JP3417951B2/ja not_active Expired - Fee Related
- 1997-05-12 PA PA19978429401A patent/PA8429401A1/es unknown
- 1997-05-14 ID IDP971607A patent/ID20291A/id unknown

Also Published As

Publication number	Publication date
JP3417951B2 (ja)	2003-06-16
HRP970246B1 (en)	2002-04-30
WO1997043238A1 (en)	1997-11-20
TW467892B (en)	2001-12-11
AR007096A1 (es)	1999-10-13
CA2253869A1 (en)	1997-11-20
AU727648B2 (en)	2000-12-21
YU18797A (en)	1999-11-22
TNSN97085A1 (fr)	2005-03-15
CO4990925A1 (es)	2000-12-26
PA8429401A1 (es)	2000-05-24
PE65998A1 (es)	1998-10-20
CN1225622A (zh)	1999-08-11
JPH11509870A (ja)	1999-08-31
HRP970246A2 (en)	1998-04-30
ZA974032B (en)	1998-02-19
EP0912487A1 (en)	1999-05-06
SV1997000034A (es)	1999-07-05
CN1163466C (zh)	2004-08-25
ID20291A (id)	1998-11-19
CA2253869C (en)	2003-04-22
AU3121997A (en)	1997-12-05

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