MY133532A - Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics - Google Patents

Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics

Info

Publication number
MY133532A
MY133532A MYPI98002658A MYPI9802658A MY133532A MY 133532 A MY133532 A MY 133532A MY PI98002658 A MYPI98002658 A MY PI98002658A MY PI9802658 A MYPI9802658 A MY PI9802658A MY 133532 A MY133532 A MY 133532A
Authority
MY
Malaysia
Prior art keywords
formula
kinetic resolution
preparing substituted
intermediate useful
enzymatic kinetic
Prior art date
Application number
MYPI98002658A
Inventor
William Brian Morgan
Jinchu Liu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MY133532A publication Critical patent/MY133532A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

THE INVENTION RELATES TO A PROCESS FOR PREPARING A SUBSTITUTED (6, 11-DIHYDRO-5H-BENZO [5,6] CYCLOHEPTA [1,2-B] PYRIDIN-11-YL) PIPERIDINE COMPOUND OF THE FORMULA (+)-I(FORMULA 1)WHEREIN:R, R1,R2, R3 AND R4 ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALO, C1-C6 ALKYL, AMINO, -OCH3, -OCF3 AND CF3, AND THE DOTTED LINE REPRESENTS AN OPTIONAL DOUBLE BOND; COMPRISING; ENZYMATICALLY CATALYZING THE ACYLATION OF COMPOUND OF THE FORMULA (±)- II(FORMULA 2)WHEREIN THE VARIABLES ARE AS DEFINED ABOVE, AND HYDROLYSING THE PRODUCT TO OBTAIN (+)-I
MYPI98002658A 1997-06-17 1998-06-15 Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics MY133532A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87767597A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
MY133532A true MY133532A (en) 2007-11-30

Family

ID=25370483

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI98002658A MY133532A (en) 1997-06-17 1998-06-15 Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics

Country Status (9)

Country Link
EP (1) EP1002123A1 (en)
JP (1) JP3421355B2 (en)
AR (1) AR015892A1 (en)
AU (1) AU8058398A (en)
CA (1) CA2293708C (en)
IN (1) IN187248B (en)
MY (1) MY133532A (en)
WO (1) WO1998058073A1 (en)
ZA (1) ZA985217B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706883B1 (en) 1998-07-02 2004-03-16 Schering Corporation Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-B]pyridin-11-YL)-1-piperdine
AU4828299A (en) * 1998-07-02 2000-01-24 Schering Corporation Process for producing (8- chloro-3,10- dibromo-6,11- dihydro- 5h-benzo (5,6)cyclohepta (1,2-b)pyridin-11-yl)- 1-piperidine
ATE346159T1 (en) 2000-05-08 2006-12-15 Pfizer Prod Inc ENZYMATIC CLEAVAGE OF SELECTIVE MODULATORS OF THE ESTROGEN RECEPTOR

Also Published As

Publication number Publication date
AU8058398A (en) 1999-01-04
WO1998058073A1 (en) 1998-12-23
IN187248B (en) 2002-03-09
CA2293708C (en) 2004-05-11
CA2293708A1 (en) 1998-12-23
EP1002123A1 (en) 2000-05-24
JP2000512862A (en) 2000-10-03
AR015892A1 (en) 2001-05-30
JP3421355B2 (en) 2003-06-30
ZA985217B (en) 1999-01-07

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