MY135405A - Anth1 chimeric antagonist - Google Patents
Anth1 chimeric antagonistInfo
- Publication number
- MY135405A MY135405A MYPI20032059A MY135405A MY 135405 A MY135405 A MY 135405A MY PI20032059 A MYPI20032059 A MY PI20032059A MY 135405 A MY135405 A MY 135405A
- Authority
- MY
- Malaysia
- Prior art keywords
- ifn
- inhibits
- growth stimulating
- anth1
- stimulating activity
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000006354 HLA-DR Antigens Human genes 0.000 abstract 1
- 108010058597 HLA-DR Antigens Proteins 0.000 abstract 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 102000055277 human IL2 Human genes 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A RECOMBINANT CHIMERIC ANTAGONIST FORMED BY A 60 AMINO ACID FRAGMENT OF THE NTERMINAL REGION OF HUMAN INTERLEUKIN 2 (IL-2) FUSED TO THE N-TERMINAL OF THE EXTRACELLULAR REGION OF THE ALPHA SUBUNIT OF THE GAMMA IFN (IFN γ) RECEPTOR. IN VITRO THIS PROTEIN HAS A T CELL GROWTH STIMULATING ACTIVITY, IT INHIBITS THE GROWTH STIMULATING ACTIVITY OF IL-2 IN T CELLS, IT INHIBITS THE INDUCTION OF HLA-DR BY IFN γ AND IT INHIBITS THE ANTIPROLIFERATIVE ACTIVITY OF γ IFN. THIS INVENTION CAN BE APPLIED IN THE FIELD OF MEDICINE FOR THE TREATMENT OF SEVERAL PATHOLOGIES SUCH AS AUTOIMMUNE DISEASES, GRAFT REJECTIONS, CHRONIC INFLAMMATIONS, SEPSIS, ISCHEMIA AND REPERFUSION SYNDROME AND ATHEROSCLEROSIS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20032059 MY135405A (en) | 2003-06-03 | 2003-06-03 | Anth1 chimeric antagonist |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20032059 MY135405A (en) | 2003-06-03 | 2003-06-03 | Anth1 chimeric antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY135405A true MY135405A (en) | 2008-04-30 |
Family
ID=45891145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20032059 MY135405A (en) | 2003-06-03 | 2003-06-03 | Anth1 chimeric antagonist |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY135405A (en) |
-
2003
- 2003-06-03 MY MYPI20032059 patent/MY135405A/en unknown
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