MY136639A - New process for the synthesis of (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and esters thereof, and application in the synthesis of perindopril - Google Patents
New process for the synthesis of (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and esters thereof, and application in the synthesis of perindoprilInfo
- Publication number
- MY136639A MY136639A MYPI20041884A MYPI20041884A MY136639A MY 136639 A MY136639 A MY 136639A MY PI20041884 A MYPI20041884 A MY PI20041884A MY PI20041884 A MYPI20041884 A MY PI20041884A MY 136639 A MY136639 A MY 136639A
- Authority
- MY
- Malaysia
- Prior art keywords
- synthesis
- perindopril
- application
- perhydroindole
- esters
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 2
- 229960002582 perindopril Drugs 0.000 title abstract 2
- CQYBNXGHMBNGCG-FXQIFTODSA-N (2s,3as,7as)-2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCC[C@@H]2[NH2+][C@H](C(=O)[O-])C[C@@H]21 CQYBNXGHMBNGCG-FXQIFTODSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCESS FOR THE SYNTHESIS OF COMPOUNDS OF FORMULA (I) :(I)WHEREIN R WHEREIN R REPRESENTS A HYDROGEN ATOM OR A BENZYL OR LINEAR OR BRANCHED (C1-C6)ALKYL GROUP, AND ADDITION SALTS THEREOF WITH A MINERAL OR ORGANIC ACID OR BASE.APPLICATION IN THE SYNTHESIS OF PERINDOPRIL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291157A EP1354875B1 (en) | 2003-05-19 | 2003-05-19 | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY136639A true MY136639A (en) | 2008-11-28 |
Family
ID=28459641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20041884A MY136639A (en) | 2003-05-19 | 2004-05-19 | New process for the synthesis of (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and esters thereof, and application in the synthesis of perindopril |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1354875B1 (en) |
| AR (1) | AR044392A1 (en) |
| AT (1) | ATE283258T1 (en) |
| DE (1) | DE60300168T2 (en) |
| DK (1) | DK1354875T3 (en) |
| ES (1) | ES2233914T3 (en) |
| MY (1) | MY136639A (en) |
| PT (1) | PT1354875E (en) |
| SI (1) | SI1354875T1 (en) |
| WO (1) | WO2004103969A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391945C (en) * | 2005-05-31 | 2008-06-04 | 浙江大学 | A kind of synthetic method of S-(-)-indoline-2-carboxylic acid |
| WO2014012851A1 (en) | 2012-07-17 | 2014-01-23 | F. Hoffmann-La Roche Ag | Arylethynyl derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ202903A (en) * | 1981-12-29 | 1988-01-08 | Hoechst Ag | 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions |
| FR2620703B1 (en) * | 1987-09-17 | 1991-10-04 | Adir | PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERHYDROINDOLE CARBOXYLIC ACID - 2 (2S, 3AS, 7AS). APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES |
-
2003
- 2003-05-19 PT PT03291157T patent/PT1354875E/en unknown
- 2003-05-19 AT AT03291157T patent/ATE283258T1/en active
- 2003-05-19 DE DE60300168T patent/DE60300168T2/en not_active Expired - Lifetime
- 2003-05-19 SI SI200330011T patent/SI1354875T1/en unknown
- 2003-05-19 EP EP03291157A patent/EP1354875B1/en not_active Expired - Lifetime
- 2003-05-19 DK DK03291157T patent/DK1354875T3/en active
- 2003-05-19 ES ES03291157T patent/ES2233914T3/en not_active Expired - Lifetime
-
2004
- 2004-05-19 MY MYPI20041884A patent/MY136639A/en unknown
- 2004-05-19 WO PCT/FR2004/001225 patent/WO2004103969A1/en not_active Ceased
- 2004-05-19 AR ARP040101725A patent/AR044392A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60300168D1 (en) | 2004-12-30 |
| AR044392A1 (en) | 2005-09-14 |
| ES2233914T3 (en) | 2005-06-16 |
| WO2004103969A1 (en) | 2004-12-02 |
| ATE283258T1 (en) | 2004-12-15 |
| EP1354875A1 (en) | 2003-10-22 |
| DE60300168T2 (en) | 2005-12-01 |
| PT1354875E (en) | 2005-03-31 |
| EP1354875B1 (en) | 2004-11-24 |
| SI1354875T1 (en) | 2005-02-28 |
| DK1354875T3 (en) | 2005-03-14 |
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