MY138057A - Novel bicyclic inhibitors of hormone sensitive lipase - Google Patents
Novel bicyclic inhibitors of hormone sensitive lipaseInfo
- Publication number
- MY138057A MY138057A MYPI20033883A MYPI20033883A MY138057A MY 138057 A MY138057 A MY 138057A MY PI20033883 A MYPI20033883 A MY PI20033883A MY PI20033883 A MYPI20033883 A MY PI20033883A MY 138057 A MY138057 A MY 138057A
- Authority
- MY
- Malaysia
- Prior art keywords
- sensitive lipase
- hormone sensitive
- novel bicyclic
- bicyclic inhibitors
- inhibitors
- Prior art date
Links
- 102000000019 Sterol Esterase Human genes 0.000 title abstract 2
- 108010055297 Sterol Esterase Proteins 0.000 title abstract 2
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001565 benzotriazoles Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
BENZOTRIAZOLES OF THE FORMULA IIIN WHICH R1 TO R8 HAVE THE ABOVEMENTIONED MEANINGS AND PROCESS FOR THEIR PREPARATION ARE DESCRIBED. THE COMPOUNDS SHOW AN INHIBITORY EFFECT ON HORMONE-SENSITIVE LIPASE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10247680A DE10247680B4 (en) | 2002-10-12 | 2002-10-12 | New bicyclic inhibitors of the hormone sensitive lipase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY138057A true MY138057A (en) | 2009-04-30 |
Family
ID=32038583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20033883A MY138057A (en) | 2002-10-12 | 2003-10-10 | Novel bicyclic inhibitors of hormone sensitive lipase |
Country Status (38)
| Country | Link |
|---|---|
| EP (1) | EP1554259B1 (en) |
| JP (2) | JP4658607B2 (en) |
| KR (1) | KR20050059254A (en) |
| CN (1) | CN100366616C (en) |
| AR (1) | AR041565A1 (en) |
| AT (1) | ATE349433T1 (en) |
| AU (1) | AU2003275997B8 (en) |
| BR (1) | BR0315257A (en) |
| CA (1) | CA2501734C (en) |
| CR (1) | CR7717A (en) |
| CY (1) | CY1106358T1 (en) |
| DE (2) | DE10247680B4 (en) |
| DK (1) | DK1554259T3 (en) |
| EC (1) | ECSP055729A (en) |
| ES (1) | ES2277152T3 (en) |
| GT (1) | GT200300214A (en) |
| HN (1) | HN2003000316A (en) |
| HR (1) | HRP20050325A2 (en) |
| IL (1) | IL167907A (en) |
| JO (1) | JO2497B1 (en) |
| MA (1) | MA27404A1 (en) |
| MX (1) | MXPA05003359A (en) |
| MY (1) | MY138057A (en) |
| NO (1) | NO20052291L (en) |
| OA (1) | OA12941A (en) |
| PA (1) | PA8585101A1 (en) |
| PE (1) | PE20040776A1 (en) |
| PL (1) | PL374605A1 (en) |
| PT (1) | PT1554259E (en) |
| RS (1) | RS51543B (en) |
| RU (1) | RU2325385C2 (en) |
| SV (1) | SV2004001633A (en) |
| TN (1) | TNSN05105A1 (en) |
| TW (1) | TWI313265B (en) |
| UA (1) | UA79994C2 (en) |
| UY (1) | UY28015A1 (en) |
| WO (1) | WO2004035550A1 (en) |
| ZA (1) | ZA200501757B (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005002130A1 (en) | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | New substituted aminomethylene sulfonamides useful as hormone sensitive lipase inhibitors in medicaments for treatment and/or prevention of non-insulin dependent diabetes mellitus, diabetic syndrome or obesity |
| DE102005026809A1 (en) * | 2005-06-09 | 2006-12-14 | Sanofi-Aventis Deutschland Gmbh | Benzothiazol-2-one derivatives as inhibitors of lipases and phospholipases |
| DE102005026808A1 (en) | 2005-06-09 | 2006-12-14 | Sanofi-Aventis Deutschland Gmbh | Benzooxazol-2-one derivatives as inhibitors of lipases and phospholipases |
| DE102005026762A1 (en) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-one derivatives as inhibitors of lipases and phospholipases |
| DE102005048897A1 (en) | 2005-10-12 | 2007-04-19 | Sanofi-Aventis Deutschland Gmbh | Diacylindazole derivatives as inhibitors of lipases and phospholipases |
| DE102005049953A1 (en) * | 2005-10-19 | 2007-04-26 | Sanofi-Aventis Deutschland Gmbh | Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases |
| DE102005049954A1 (en) | 2005-10-19 | 2007-05-31 | Sanofi-Aventis Deutschland Gmbh | Triazolopyridine derivatives as inhibitors of lipases and phospholipases |
| FR2915198B1 (en) * | 2007-04-18 | 2009-12-18 | Sanofi Aventis | TRIAZOLOPYRIDINE CARBOXAMIDE AND TRIAZOLOPYRIDINE -CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
| FR2915199B1 (en) * | 2007-04-18 | 2010-01-22 | Sanofi Aventis | TRIAZOLOPYRIDINE-CARBOXAMIDE AND TRIAZOLOPYRIMIDINE-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
| FR2915197B1 (en) | 2007-04-18 | 2009-06-12 | Sanofi Aventis Sa | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF. |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| AU2009330821B2 (en) * | 2008-12-24 | 2015-06-11 | Bial - Portela & Ca, S.A. | Pharmaceutical compounds |
| US8329904B2 (en) * | 2009-05-12 | 2012-12-11 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
| US8440710B2 (en) * | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| US8097634B2 (en) * | 2010-04-15 | 2012-01-17 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
| US8450350B2 (en) * | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| US8722721B2 (en) * | 2011-03-16 | 2014-05-13 | Hoffmann-La Roche Inc. | SEC-hydroxycyclohexyl derivatives |
| US8703807B2 (en) * | 2011-03-17 | 2014-04-22 | Hoffmann-La Roche Inc. | Azaspirodecanone compounds |
| US8809384B2 (en) * | 2011-03-25 | 2014-08-19 | Hoffmann-La Roche Inc. | Azaspirodecanone compounds |
| UA119247C2 (en) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
| GB201321740D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| KR20210102887A (en) | 2018-11-14 | 2021-08-20 | 알타반트 사이언시스 게엠베하 | Crystalline spirocyclic compound inhibitors of tryptophan hydroxylase 1 (TPH1) for treating diseases or disorders associated with peripheral serotonin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1126999A (en) * | 1978-10-20 | 1982-07-06 | Michael J. Simons | Use of azole compounds with a n,n disubstituted carbamoyl group on a ring nitrogen as development restrainer precursors in photographic elements |
| US5369086A (en) * | 1993-04-28 | 1994-11-29 | Zeneca Limited | N-benzotriazoles |
| DE19942354A1 (en) * | 1999-09-04 | 2001-03-08 | Aventis Pharma Gmbh | Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, their manufacture and use in medicinal products |
| BR0209334A (en) * | 2001-05-05 | 2004-06-15 | Smithkline Beecham Plc | Cyclic n-aroil amines |
| BR0214967A (en) * | 2001-12-14 | 2005-05-10 | Novo Nordisk As | Compound, pharmaceutically acceptable salt, process for preparing a compound, pharmaceutical composition, use of a compound and method of treating a patient disorder |
-
2002
- 2002-10-12 DE DE10247680A patent/DE10247680B4/en not_active Expired - Fee Related
-
2003
- 2003-09-27 CN CNB038241420A patent/CN100366616C/en not_active Expired - Fee Related
- 2003-09-27 AU AU2003275997A patent/AU2003275997B8/en not_active Ceased
- 2003-09-27 PL PL03374605A patent/PL374605A1/en not_active Application Discontinuation
- 2003-09-27 EP EP03808700A patent/EP1554259B1/en not_active Expired - Lifetime
- 2003-09-27 PT PT03808700T patent/PT1554259E/en unknown
- 2003-09-27 OA OA1200500103A patent/OA12941A/en unknown
- 2003-09-27 ES ES03808700T patent/ES2277152T3/en not_active Expired - Lifetime
- 2003-09-27 UA UAA200504422A patent/UA79994C2/en unknown
- 2003-09-27 DK DK03808700T patent/DK1554259T3/en active
- 2003-09-27 AT AT03808700T patent/ATE349433T1/en active
- 2003-09-27 BR BR0315257-0A patent/BR0315257A/en not_active IP Right Cessation
- 2003-09-27 RS YUP-2005/0207A patent/RS51543B/en unknown
- 2003-09-27 WO PCT/EP2003/010765 patent/WO2004035550A1/en not_active Ceased
- 2003-09-27 MX MXPA05003359A patent/MXPA05003359A/en active IP Right Grant
- 2003-09-27 JP JP2004544048A patent/JP4658607B2/en not_active Expired - Fee Related
- 2003-09-27 HR HR20050325A patent/HRP20050325A2/en not_active Application Discontinuation
- 2003-09-27 CA CA2501734A patent/CA2501734C/en not_active Expired - Fee Related
- 2003-09-27 DE DE50306134T patent/DE50306134D1/en not_active Expired - Lifetime
- 2003-09-27 RU RU2005114394/04A patent/RU2325385C2/en not_active IP Right Cessation
- 2003-09-27 KR KR1020057006312A patent/KR20050059254A/en not_active Ceased
- 2003-09-29 JO JO2003123A patent/JO2497B1/en active
- 2003-09-29 GT GT200300214A patent/GT200300214A/en unknown
- 2003-10-08 TW TW092127898A patent/TWI313265B/en active
- 2003-10-08 SV SV2003001633A patent/SV2004001633A/en not_active Application Discontinuation
- 2003-10-09 PA PA20038585101A patent/PA8585101A1/en unknown
- 2003-10-09 AR ARP030103676A patent/AR041565A1/en unknown
- 2003-10-09 PE PE2003001028A patent/PE20040776A1/en not_active Application Discontinuation
- 2003-10-09 HN HN2003000316A patent/HN2003000316A/en unknown
- 2003-10-10 MY MYPI20033883A patent/MY138057A/en unknown
- 2003-10-10 UY UY28015A patent/UY28015A1/en unknown
-
2005
- 2005-03-01 ZA ZA200501757A patent/ZA200501757B/en unknown
- 2005-03-07 CR CR7717A patent/CR7717A/en unknown
- 2005-04-07 IL IL167907A patent/IL167907A/en not_active IP Right Cessation
- 2005-04-11 TN TNP2005000105A patent/TNSN05105A1/en unknown
- 2005-04-11 EC EC2005005729A patent/ECSP055729A/en unknown
- 2005-04-11 MA MA28213A patent/MA27404A1/en unknown
- 2005-05-10 NO NO20052291A patent/NO20052291L/en not_active Application Discontinuation
-
2007
- 2007-03-06 CY CY20071100315T patent/CY1106358T1/en unknown
-
2010
- 2010-10-08 JP JP2010228107A patent/JP2011026342A/en not_active Abandoned
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