MY141460A - Aromatic sulfone hydroxamic acid metalloprotease inhibitor - Google Patents
Aromatic sulfone hydroxamic acid metalloprotease inhibitorInfo
- Publication number
- MY141460A MY141460A MYPI9805281A MY141460A MY 141460 A MY141460 A MY 141460A MY PI9805281 A MYPI9805281 A MY PI9805281A MY 141460 A MY141460 A MY 141460A
- Authority
- MY
- Malaysia
- Prior art keywords
- mmp
- hydroxamic acid
- aromatic sulfone
- metalloprotease inhibitor
- sulfone hydroxamic
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003475 metalloproteinase inhibitor Substances 0.000 title abstract 2
- 150000003457 sulfones Chemical class 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 title 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 2
- 108010006035 Metalloproteases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 abstract 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 abstract 1
- 102100027995 Collagenase 3 Human genes 0.000 abstract 1
- 108050005238 Collagenase 3 Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 abstract 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A TREATMENT PROCESS IS DISCLOSED THAT COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF AN AROMATIC SULFONE HYDROXAMIC ACID THAT EXHIBITS EXCELLENT INHIBITORY ACTIVITY OF ONE OR MORE MATRIX METALLOPROTEASE (MMP) ENZYMES, SUCH AS MMP-2, MMP-9 AND MMP-13, WHILE EXHIBITING SUBSTANTIALLY LESS INHIBITION AT LEAST OF MMP-L TO A HOST HAVING A CONDITION ASSOCIATED WITH PATHOLOGICAL MATRIX METALLOPROTEASE ACTIVITY. ALSO DISCLOSED ARE METALLOPROTEASE INHIBITOR COMPOUNDS HAVING THOSE SELECTIVE ACTIVITIES, PROCESSES FOR MANUFACTURE OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION USING AN INHIBITOR.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI9805281 MY141460A (en) | 1998-11-19 | 1998-11-19 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI9805281 MY141460A (en) | 1998-11-19 | 1998-11-19 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY141460A true MY141460A (en) | 2010-04-30 |
Family
ID=44256728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI9805281 MY141460A (en) | 1998-11-19 | 1998-11-19 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY141460A (en) |
-
1998
- 1998-11-19 MY MYPI9805281 patent/MY141460A/en unknown
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