MY141464A - Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof - Google Patents
Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereofInfo
- Publication number
- MY141464A MY141464A MYPI9805800A MY141464A MY 141464 A MY141464 A MY 141464A MY PI9805800 A MYPI9805800 A MY PI9805800A MY 141464 A MY141464 A MY 141464A
- Authority
- MY
- Malaysia
- Prior art keywords
- tetraphosphate
- uridine
- methods
- salts
- scale production
- Prior art date
Links
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 title abstract 3
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 title abstract 3
- 229940045145 uridine Drugs 0.000 title abstract 3
- 238000011031 large-scale manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- VBGNEGYAPSWNQQ-VWDXAFRGSA-N 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione [hydroxy(phosphonooxy)phosphoryl] phosphono hydrogen phosphate Chemical compound OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O.OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O.OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O VBGNEGYAPSWNQQ-VWDXAFRGSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
THE PRESENT INVENTION PROVIDES NEW METHODS FOR THE SYNTHESIS OF THE THERAPEUTIC DINUCLEOTIDE, PL,P4-DI(URIDINE 5')-TETRAPHOSPHATE, AND DEMONSTRATES APPLICABILITY TO THE PRODUCTION OF LARGE QUANTITIES. THE METHODS OF THE PRESENT INVENTION SUBSTANTIALLY REDUCE THE TIME PERIOD REQUIRED TO SYNTHESIZE DIURIDINE TETRAPHOSPHATE, PREFERABLY TO THREE DAYS OR LESS. THE NOVEL TETRAMMONIUM AND TETRASODIUM SALTS OF PL,P4-DI(URIDINE 5')-TETRAPHOSPHATE (FORMULA I) PREPARED BY THESE METHODS ARE STABLE, SOLUBLE, NONTOXIC, AND EASY TO HANDLE DURING MANUFACTURE. FORMULA I. WHEREIN: X IS N A, NH4 OR H, PROVIDED THAT ALL X GROUPS ARE NOT H.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI9805800 MY141464A (en) | 1998-12-21 | 1998-12-21 | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI9805800 MY141464A (en) | 1998-12-21 | 1998-12-21 | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY141464A true MY141464A (en) | 2010-04-30 |
Family
ID=44256730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI9805800 MY141464A (en) | 1998-12-21 | 1998-12-21 | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY141464A (en) |
-
1998
- 1998-12-21 MY MYPI9805800 patent/MY141464A/en unknown
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