MY149603A - Novel antibiotics, bispolides a1, a2, and a3, as well as bispolides b1, b2a, b2b and b3, and process for producing these antibiotics - Google Patents
Novel antibiotics, bispolides a1, a2, and a3, as well as bispolides b1, b2a, b2b and b3, and process for producing these antibioticsInfo
- Publication number
- MY149603A MY149603A MYPI20064628A MY149603A MY 149603 A MY149603 A MY 149603A MY PI20064628 A MYPI20064628 A MY PI20064628A MY 149603 A MY149603 A MY 149603A
- Authority
- MY
- Malaysia
- Prior art keywords
- bispolide
- bispolides
- hydrogen atom
- methyl group
- antibiotics
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 4
- 229940088710 antibiotic agent Drugs 0.000 title abstract 3
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 4
- -1 METHYL GROUP Chemical group 0.000 abstract 4
- LQZSXRNWHMNBRC-ZIANLMASSA-N bispolide B2a Natural products CC[C@@H]1C=CC=C(CC)C=CC(=O)O[C@H]([C@H](C)[C@H](O)C[C@]2(C[C@@H](O[C@H]3C[C@@H](O)[C@H](O)[C@@H](C)O3)[C@H](CC)[C@@H](C)O2)OC)[C@H](CC)C=CC=C(CC)C=CC(=O)O[C@@H]1[C@H](C)[C@H](O)C[C@]4(O)C[C@@H](O[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@@H]5O)[C@H](CC)[C@@H](C)O4 LQZSXRNWHMNBRC-ZIANLMASSA-N 0.000 abstract 3
- JZUWMNDFGYWJGS-LOJZUSKGSA-N bispolide B2b Natural products CC[C@@H]1C=CC=C(CC)C=CC(=O)O[C@H]([C@H](C)[C@H](O)C[C@]2(C[C@@H](O[C@H]3O[C@H](C)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](CC)[C@H](C)O2)OC)[C@H](CC)C=CC=C(CC)C=CC(=O)O[C@@H]1[C@H](C)[C@H](O)C[C@]4(O)C[C@@H](O[C@H]5C[C@H](O)[C@H](O)[C@@H](C)O5)[C@H](CC)[C@@H](C)O4 JZUWMNDFGYWJGS-LOJZUSKGSA-N 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 241000906785 Microbispora sp. Species 0.000 abstract 1
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
IN THIS INVENTION, THERE ARE PROVIDED NOVEL ANTIBIOTICS, BISPOLIDE B1, BISPOLIDE B2A, BISPOLIDE B2B AND BISPOLIDE B3 WHICH ARE EACH A COMPOUND HAVING THE FORMULA (II): WHEREIN R� AND R� EACH DENOTE A HYDROGEN ATOM OR METHYL GROUP (-CH3), AND R� AND R� ARE EACH A HYDROGEN ATOM FOR BISPOLIDE B1; R� IS A HYDROGEN ATOM AND R� IS METHYL GROUP FOR BISPOLIDE B2A; R� IS METHYL GROUP AND R� IS A HYDROGEN ATOM FOR BISPOLIDE B2B; AND R� AND R� ARE EACH METHYL GROUP FOR BISPOLIDE B3. BISPOLIDE B1, BISPOLIDE B2A, BISPOLIDE B2B AND BISPOLIDE B3 MAY COLLECTIVELY BE NAMED AS A BISPOLIDE B AND ARE EACH AN ANTIBIOTIC HAVING A HIGH ANTIBACTERIAL ACTIVITY AGAINST BACTERIA SUCH AS GRAM-POSITIVE BACTERIA, INCLUDING METHICILLIN-RESISTANT STRAINS OF STAPHYLOCOCCUS AUREUS. IN THIS INVENTION, THERE IS ALSO PROVIDED A PROCESS OF PRODUCING A BISPOLIDE B COMPRISING CULTIVATING A MICROBIAL STRAIN DESIGNATED AS MICROBISPORA SP. A34030 (DEPOSITED UNDER AN ACCESS NUMBER OF FERM BP-10505). THERE IS FURTHER PROVIDED A PHARMACEUTICAL COMPOSITION COMPRISING A BISPOLIDE B AS AN ACTIVE INGREDIENT.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20064628 MY149603A (en) | 2006-12-06 | 2006-12-06 | Novel antibiotics, bispolides a1, a2, and a3, as well as bispolides b1, b2a, b2b and b3, and process for producing these antibiotics |
| US12/300,468 US8318684B2 (en) | 2006-05-16 | 2007-05-15 | Antibiotics, bispolides A1, A2, and A3 as well as bispolides B1, B2a, B2b and B3 and processes for producing said antibiotics |
| PCT/JP2007/060304 WO2007132937A1 (en) | 2006-05-16 | 2007-05-15 | NOVEL ANTIBIOTICS, BISPOLIDES A1, A2 AND A3 AND BISPOLIDES B1, B2a, B2b AND B3 AND METHOD FOR PRODUCING THE ANTIBIOTICS |
| EP07743739A EP2025758A1 (en) | 2006-05-16 | 2007-05-15 | NOVEL ANTIBIOTICS, BISPOLIDES A1, A2 AND A3 AND BISPOLIDES B1, B2a, B2b AND B3 AND METHOD FOR PRODUCING THE ANTIBIOTICS |
| JP2008515607A JP4755248B2 (en) | 2006-05-16 | 2007-05-15 | Novel antibiotics, bisporides A1, A2 and A3 and bisporides B1, B2a, B2b and B3 and methods for producing these antibiotics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI20064628 MY149603A (en) | 2006-12-06 | 2006-12-06 | Novel antibiotics, bispolides a1, a2, and a3, as well as bispolides b1, b2a, b2b and b3, and process for producing these antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY149603A true MY149603A (en) | 2013-09-13 |
Family
ID=50279057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20064628 MY149603A (en) | 2006-05-16 | 2006-12-06 | Novel antibiotics, bispolides a1, a2, and a3, as well as bispolides b1, b2a, b2b and b3, and process for producing these antibiotics |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY149603A (en) |
-
2006
- 2006-12-06 MY MYPI20064628 patent/MY149603A/en unknown
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